A5049638501- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- Cardiac and Coronary Surgery Techniques
- Inflammatory mediators and NSAID effects
- Cardiac Structural Anomalies and Repair
- Chemotherapy-induced cardiotoxicity and mitigation
- Advanced Glycation End Products research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiac electrophysiology and arrhythmias
- Sirtuins and Resveratrol in Medicine
- Artificial Intelligence in Healthcare
- Gout, Hyperuricemia, Uric Acid
- COVID-19 diagnosis using AI
- Calpain Protease Function and Regulation
- Genetics, Aging, and Longevity in Model Organisms
- Extracellular vesicles in disease
- Calcium signaling and nucleotide metabolism
- Medicinal Plants and Neuroprotection
- Multiple Sclerosis Research Studies
- Machine Learning in Healthcare
- Diabetes Management and Research
- Erythropoietin and Anemia Treatment
Xijing Hospital
2015-2024
Air Force Medical University
2015-2024
First Affiliated Hospital of Fujian Medical University
2024
Fujian Medical University
2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2023-2024
Chinese People's Liberation Army
2024
General Hospital of Shenyang Military Region
2021-2023
Karolinska University Hospital
2021
Karolinska Institutet
2001-2021
Merck & Co., Inc., Rahway, NJ, USA (United States)
2019
Doxorubicin (Dox), an anthracycline antibiotic with potent antitumor effects, has limited clinical applications due to cumulative cardiotoxicity. Ca2+ /calmodulin-dependent protein kinase II (CaMKII) is implicated in the pathological progression of Dox-induced This study examined hypothesis that CaMKII exacerbates cardiotoxicity by promoting endoplasmic reticulum stress and apoptosis through regulation inositol-requiring enzyme 1α (IRE1α)/spliced X-box binding 1 (XBP1s) pathway. Our results...
Abstract Although reperfusion is the most effective therapy for patients with acute myocardial infarction, injury limits therapeutic effects of early reperfusion. Oxidative stress plays a crucial role in ischaemia/reperfusion (I/R) injury. Melatonin, circulating hormone, well‐known as an antioxidant cardiovascular diseases. In this short communication, we show that melatonin significantly improves post‐ischaemic cardiac function, reduces infarct size and decreases oxidative stress....
Diabetic cardiomyopathy (DCM) is a chronic microvascular complication of diabetes that generally defined as ventricular dysfunction occurring in patients with and unrelated to known causes. Several mechanisms have been proposed contribute the occurrence persistence DCM, which oxidative stress autophagy play non-negligible role. involved variety physiological pathological processes. The 5' adenosine monophosphate-activated protein kinase/nuclear factor-erythroid 2-related factor 2 (AMPK/Nrf2)...
This study was designed to investigate whether berbamine (BA)-induced cardioprotective effects were related 5' adenosine monophosphate-activated protein kinase (AMPK)/nuclear factor erythroid 2-related (Nrf2) signaling and changes in the mitochondria myocardial ischemia/reperfusion (I/R) injury. C57/BL6 mice exposed BA (10 mg/kg/d), with or without administration of AMPK specific inhibitor compound C (5 mg/kg/d) Nrf2 ML-385 (30 then subjected a I/R operation. As expected, significantly...
Atrial fibrillation (AF) is the most frequent arrythmia managed in clinical practice. Several mechanisms have been proposed to contribute occurrence and persistence of AF, which oxidative stress plays a non-negligible role. The endocannabinoid system (ECS) involved variety physiological pathological processes. Cannabinoid receptor 1 (CB1R) cannabinoid 2 (CB2R) are expressed heart, studies shown that activating CB2R has protective effect on myocardium. However, role AF unknown.Angiotensin II...
Quadricuspid aortic valve (QAV) is a rare congenital malformation that can present with regurgitation or stenosis (AS)), requiring surgical treatment. Transcatheter replacement (TAVR) an alternative treatment for older patients and its prognosis QAV therapy remains challenging. We sought to examine our early experience TAVR in QAV.Prospectively collected data were retrospectively reviewed undergoing institution.Five AR AS treated between January 2016 2022. The mean age was 73.8 years (range...
Objectives. The purpose of this study was to review the experiences with transcatheter closure mitral PVL after surgical valve replacement. Background. Transcatheter paravalvular leak (PVL) is an intricate alternative closure. But it represents one most procedures in field structural heart interventions, especially for patients PVL. Methods. From January 2015 through 2019, 35 replacement underwent We reviewed catheter techniques, perioperative characteristics, and prognosis. median follow-up...
Abstract This study was designed to explore the role of RIP3 in DOX-induced cardiotoxicity and its underlying molecular mechanisms.Ourresults demonstrate that exacerbates DOX-inducedcardiotoxicity through promoting oxidative stress pyroptosis by regulating AKT/Nuclear factor erythroid 2-related 2 (Nrf2) pathway. Inhibition using GSK-872 attenuated cardiac remodeling contractile dysfunction. Moreover, vivo , results revealed inhibition alleviated resulting pyroptosis. Besides, increased...
Our goal was to assess the implant depth of a Venus-A prosthesis during transcatheter aortic valve replacement (TAVR) when areas eccentric calcification were distributed in different sections valve.A total 53 patients with who underwent TAVR from January 2018 November 2019 retrospectively analyzed. The divided into three groups (A, B, and C) according location calcification, which determined by preprocedural computerized tomography angiography (CTA) images. release process position evaluated...
<title>Abstract</title> Background To evaluate the feasibility, effectiveness and assistant effect of 3D printed aortic model in treatment on congenital coarctation aorta (CoA) adolescents adults. Methods From December 2018 to 2023, a total 10 patients with underwent percutaneous balloon dilatation covered stent implantation cardiovascular surgery Xijing Hospital were retrospectively analyzed. There 6 males 4 females whose average age was (27.68 ± 13.45) years. One case complicated...
<title>Abstract</title> Purpose Pneumonia remains a leading cause of morbidity and mortality among children worldwide, especially in low- middle-income countries. This study explores the application machine learning (ML) models to predict ICU admission pediatric patients with severe pneumonia. Methods utilized dataset, comprising 801 acute respiratory presentation at Children's Hospital Rabat, Morocco. Patients meeting WHO criteria for pneumonia were included, excluding those who left...
Background: Transcatheter closure of percutaneous paravalvular leak (PVL) is a technically challenging procedure, especially after surgical mechanical valve replacements (SMVR), as the risk interference with prosthetic discs and complex interventional techniques required for mitral PVL closure. Our study was designed to review results transcatheter SMVR. Methods: From January 2018 through December 2023, total 64 patients SMVR underwent help preoperative 3-dimensional printing model simulator...
Background Closure of a percutaneous paravalvular leak (PVL) is technically challenging procedure because the specific anatomy postoperatively and complex catheter techniques required. Transesophageal echocardiography (TEE) three-dimensional (3D) printing might be helpful in identifying anatomical structures procedural design. Objectives The purpose this study was to review our experiences with transcatheter closure PVL guided by TEE 3D (TEE&amp;3D) printing. Methods A total 166 patients...
Background: Malondialdehyde (MDA) is a highly reactive compound produced by lipid-peroxidation in situations associated with oxidative stress. MDA can irreversibly modify proteins residues such as lysine, arginine and histidine. In addition, adducts further react acetaldehyde to generate malondialdehyde-acetaldehyde (MAA) modifications. Such modifications give rise immunogenic neo-epitopes that are recognized autoantibodies. fact, anti-MDA/MAA IgG antibodies significantly increased the serum...
Abstract Background Our goal was to determine the accuracy of 3-dimensional transesophageal echocardiography (3D-TEE) compared with that computed tomography (CT) in preoperative evaluation for transcatheter aortic valve replacement (TAVR) when errors caused by inconsistent software and method have been eliminated representativeness sample has improved. We also investigated influence root calcification on 3D-TEE annulus evaluations. Methods Part I: 45 233 patients who underwent TAVR...
To investigate the protective effect of melatonin against myocardial ischemia-reperfusion (IR) injury in mice and role Nrf2 signaling mediating this effect.
Backgrounds: Percutaneous transseptal transcatheter mitral valve-in-valve implantation (TMViV) has become an alternative minimally invasive treatment choice for patients with degenerated bioprosthesis and high surgical risk. However, approach is more technically challenging than transapical in TMViV procedures. Objective: The objective of this study was to introduce the experience applying long pre-curved sheaths procedures evaluate effect sheath techniques Methods: Between January 2020...