A5100355941- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Blood Pressure and Hypertension Studies
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- Hormonal Regulation and Hypertension
- Lipid metabolism and disorders
- Cardiac pacing and defibrillation studies
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Sodium Intake and Health
- Cardiac Ischemia and Reperfusion
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Retinal Diseases and Treatments
- Parathyroid Disorders and Treatments
- Viral Infections and Immunology Research
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- Sunflower and Safflower Cultivation
- Cardiac and Coronary Surgery Techniques
Soochow University
2018-2024
First Affiliated Hospital of Soochow University
2018-2024
Xijing Hospital
2011-2024
Eye & ENT Hospital of Fudan University
2024
Valve (United States)
2024
Air Force Medical University
2024
Weatherford College
2024
Fudan University
2018-2024
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2024
Tianjin University of Traditional Chinese Medicine
2024
Background and Purpose Atrial metabolic remodelling is critical for the process of atrial fibrillation (AF). The PPAR‐α/sirtuin 1 /PPAR co‐activator α (PGC‐1α) pathway plays an important role in maintaining energy metabolism. However, effect PPAR‐α agonist fenofibrate on AF unclear. Therefore, aim this study was to determine explore its possible mechanisms action. Experimental Approach expression proteins examined left atria patients. Thirty‐two rabbits were divided into sham, (pacing with...
Background The temporal relationship between type 2 diabetes (T2DM) and left ventricular hypertrophy (LVH) is not well established. This study aims to examine the sequence T2DM LVH/cardiac geometry patterns in middle‐aged adults. Methods Results longitudinal cohort consisted of 1000 adults (682 White individuals 318 Black individuals; 41.1% men; mean age, 36.2 years at baseline) who had data on fasting glucose/T2DM, mass index (LVMI), relative wall thickness collected twice baseline...
Torsades de Pointes (TdP) is a type of ventricular arrhythmia which could be observed as an unwanted drug-induced cardiac side effect, and it associated with repolarization abnormalities in single cells. The pharmacological evaluations TdP risk previous years mainly focused on the hERG channel due to its vital role cardiomyocytes. However, only considering drug effects led false positive predictions since action other ion channels can also have crucial regulatory repolarization. To address...
Quercetin has multiple protective effects against cardiometabolic diseases, but the biological mechanisms underlying benefits in diabetic cardiomyopathy (DCM) are unclear. A mouse DCM model was established by high-fat diet (HFD, 8 months) combined with streptozotocin injection (at mid-feeding), and quercetin (100 mg per kg day) administrated orally after streptozotocin. Our major results indicated that cardiac ejection fraction fractional shortening, mRNA levels of Collagen I CTGF, protein...
Obesity and hypertension are important risk factors of arterial stiffness. However, the complex relationship between increased body mass index (BMI), elevated blood pressure (BP), stiffness is largely unknown. We aim to examine mediation effect BP on association early life BMI, long-term burden, trend BMI with in midlife. The longitudinal study cohort consisted 1190 participants (829 whites 361 blacks, 518 males, mean age=40.0 years at follow-up) who had been examined for 4 15 times from...
Abstract Background To investigate the relationships of plasma renin, angiotensin, and aldosterone levels to blood pressure variability target organ damage in children with essential hypertension. Methods A case-control study was conducted on 132 diagnosed hypertension (103 males 29 females mean age 11.8 ± 2.4 years). The RAAS were measured using enhanced chemiluminescence method, ambulatory monitored for 24 h, then average real (ARV) calculated. Data indicators used assessing cardiac renal...
Abstract Objectives To assess the ability of left atrial (LA) strain parameters to discriminate patients with elevated pressure (LAP) from fibrillation (AF). Methods and results A total 142 non‐valvular AF who underwent first catheter ablation (CA) between November 2022 2023 were enrolled in study. Conventional speckle‐tracking echocardiography (STE) performed all within 24 h before CA, LAP was invasively measured during procedure. According mean LAP, study population classified into two...
Background: IMPROVE HF, a 24‐month performance improvement initiative for outpatient cardiology and multispecialty practices, demonstrated significant in guideline‐based use of implantable cardioverter‐defibrillators (ICDs) patients with heart failure (HF). We investigated patient, physician, practice factors associated improvements ICD use. Methods: Patients HF or postmyocardial infarction (MI) left ventricular systolic dysfunction who met eligibility criteria ICDs at baseline 24 months...
Abstract Background Biomarkers have been related to the arrhythmia recurrence following catheter ablation (CA) of atrial fibrillation (AF). We hypothesized that concurrent measurement several biomarkers would additively improve their predictive value. Methods One thousand four hundred and ten consecutive AF patients (68% male; 57.2 ± 11.6 years) undergoing CA were enrolled. Baseline characteristics, serum B type brain natriuretic peptide (BNP) high sensitivity C reactive protein (hsCRP),...
In patients with left ventricular (LV) dysssynchrony, contraction that doesn't fall into ejection period (LVEj) results in a waste of energy due to inappropriate timing, which was now widely treated by cardiac resynchronization therapy(CRT). Myocardial Contraction Efficiency defined as the ratio Efficient Time (ECTR) and amplitude efficient (ECR) during LVEj against entire cycle. This study prospectively investigated whether efficiency indexes could predict CRT outcome.Our prospective pilot...
Fibroblast growth factor 23 (FGF 23), an endocrine hormone regulating the homeostasis of phosphate and vitamin D, has been shown to play a role in cardiovascular disease. Increased blood FGF is found be associated with elevated pressure adults. However, measurement hypertensive children not documented. In this study, total 98 primary hypertension 37 controls were recruited, was comparatively investigated. Additionally, levels compared between subgroups patients after sub-grouped according...
Background Data are limited regarding the relationship between life‐course burden of risk factors and adult cardiac function. This study sought to examine impact long‐term body mass index (BMI) blood pressure (BP) levels on changes in left ventricular (LV) structure function a community‐based cohort. Methods Results The longitudinal cohort consisted 1108 patients (726 White; 41.9% men; mean age, 48.2 years last survey) who had been examined 4 16 times for BMI BP echocardiographic LV...
Left ventricular hypertrophy (LVH) is one of the most common types target organ damage in hypertension. The red blood cell distribution width (RDW) closely related to many cardiovascular diseases, including aim this study was analyze relationship between RDW level and LVH pediatric essential hypertension.A total 429 untreated children adolescents with hypertension were recruited divided into an group (n = 114) non-LVH 315) according left mass index (LVMI) relative wall thickness (RWT) by...
To evaluate left atrial (LA) phasic functions in patients with hypertension and/or paroxysmal fibrillation (PAF) and its clinical significance.LA strain was studied 77 (25 hypertension, 24 lone AF, 28 both PAF) controls using two-dimensional speckle-tracking echocardiography (2D STE). The following indexes during reservoir, conduit pump phase were analyzed respectively: (1) peak longitudinal (PALS) rate (PALSR), (2) the standard deviation of time to PALS PALSR all LA segments (TpS-SD%...
Background There is a well‐recognized gap between the number of patients in whom cardiac resynchronization therapy (CRT) indicated based on current guidelines and its actual utilization. In Registry to Improve Use Evidence‐Based Heart Failure Therapies Outpatient Setting (IMPROVE HF) study, there was significant increase use CRT at 24 months with heart failure (HF) comparison baseline. This study evaluated patient, physician, practice factors associated this Methods Patients reduced left...
Application value of hypersensitive C-reactive protein (hs-CRP), blood lactic acid (LAC) and myoglobin (Mb) in the combined detection myocarditis was explored. A total 107 patients with suspected treated The Second Nanning People's Hospital from January 2015 to December 2017 were retrospectively analyzed, whom 81 diagnosed enrolled into research group, 26 non-myocarditis individuals control group. Fasting venous drawn all detect hs-CRP, LAC Mb, their levels compared analyzed between two...
Objectives: To assess the ability of left atrial(LA) strain parameters to discriminate patients with elevated atrial pressure(LAP) from fibrillation(AF). Methods and results : A total 142 non-valvular AF who underwent first catheter ablation(CA) between November 2022 2023 were enrolled in study. Conventional speckle-tracking echocardiography（STE）were performed all within 24 hours before CA，and LAP was invasively measured during ablation procedure. According mean LAP,the study population...
This study aims to evaluate the two-year outcomes of polypoidal choroidal vasculopathy (PCV) treated with conbercept and investigate predictive response factors.