A5100460935- Cardiac Fibrosis and Remodeling
- Signaling Pathways in Disease
- Computational Drug Discovery Methods
- Electron Spin Resonance Studies
- Cancer, Lipids, and Metabolism
- Mitochondrial Function and Pathology
- Nuclear Receptors and Signaling
- Cancer Treatment and Pharmacology
- Blood Pressure and Hypertension Studies
- Plant-derived Lignans Synthesis and Bioactivity
- Tryptophan and brain disorders
- Metabolism, Diabetes, and Cancer
- Cardiac Structural Anomalies and Repair
- Cardiac Ischemia and Reperfusion
- Cancer Mechanisms and Therapy
- Circular RNAs in diseases
- Nerve injury and regeneration
- Physiological and biochemical adaptations
- Cardiovascular Health and Risk Factors
- Chemotherapy-induced cardiotoxicity and mitigation
- Quinazolinone synthesis and applications
- thermodynamics and calorimetric analyses
- Connexins and lens biology
- Cancer therapeutics and mechanisms
- Cardiovascular Effects of Exercise
Beijing University of Chinese Medicine
2017-2024
Children's Hospital of Capital Institute of Pediatrics
2023
Shanghai University of Medicine and Health Sciences
2022
Nanjing Medical University
2015
Jiangsu Province Hospital
2015
Previous studies have shown that compounds in the form of precipitate (CFP) from Huang-Lian-Jie-Du-Tang (HLJDT) were stable, and CFP content reached 2.63% whole decoction had good neuroprotective effects. However, there has been no research on their specific source. In this study, it was found HLJDT mainly came reaction Scutellaria baicalensis Coptis chinensis by studying separated prescription components (accounting for 81.33% CFP). Unlike previous CFP, chemical composition...
Approximately one in four myocardial infarctions occur older patients. The majority of therapeutic advances are either not appropriate or tested elderly main reasons for deviating from the guidelines justified concerns regarding effectiveness recommended forms therapy, fear adverse drug reactions and ethical concerns. Targeting interleukin 6 (IL‑6) ventricular remodeling after cardiovascular damage is a feasible alternative to standard polypharmaceutics, but underlying molecular mechanisms...
Left ventricular hypertrophy (LVH) is one of the most common types target organ damage in hypertension. The red blood cell distribution width (RDW) closely related to many cardiovascular diseases, including aim this study was analyze relationship between RDW level and LVH pediatric essential hypertension.A total 429 untreated children adolescents with hypertension were recruited divided into an group (n = 114) non-LVH 315) according left mass index (LVMI) relative wall thickness (RWT) by...
Yiqi Huoxue Decoction (YQHX) has been widely used for clinical treatment of ischemic heart disease. While oxidative stress plays a key role in the pathogenesis disease, function and molecular mechanism underlying antioxidative protective effects YQHX on H9c2 cardiomyocytes against ischemia/hypoxia (I/H) have yet to be well clarified. cells were subjected 12 h hypoxia with serum-free conditions then treated or without (100–400 μg/mL). Cell viability was examined using CCK-8 assay. Maleic...
Myocardial infarction can lead to ventricular remodeling and arrhythmia, which is closely related nerve remodeling. Our previous study found that Yiqi Huoxue decoction (YQHX) improve reduce myocardial damage. Therefore, in this study, we observed the effect of YQHX on cardiac neural cardiomyocyte hypertrophy its possible mechanism. This research composed two parts: animal H9c2 cells experiments. The model acute was established by ligating left anterior descending coronary artery Sprague...
Sympathetic nerve remodeling after myocardial infarction (MI) has an indispensable role in cardiac remodeling. Numerous works have shown that sympathetic can be delayed by inhibition of inflammatory response. Earlier studies improvement ventricular and inhibited chronic stage neural Yiqi Huoxue decoction (YQHX). Therefore, the current study looked at inhibitory effect YQHX prescription on proinflammatory mediators macrophages 3 7 days MI. expression Toll-like receptor 4 (TLR4) nuclear factor...
Objective To study the effects of health management on blood pressure and lifestyle hypertensive outpatients. Methods A total 319 outpatients were randomly assigned to control group (n=160) or (n=159). Pharmacologic therapy was given group, while in intensive combined with pharmacologic conducted.Blood pressure, height, body weight (BW), cholesterol (TC), fasting glucose (FBG) participants measured compared at baseline 12 months. Results There no significant differences clinical...
Abstract Background: This paper explores the effects of insomnia and menopausal syndrome on depressive process at cellular molecular levels, investigates mechanisms by which commonly used antidepressant formula, Jieyu Pill (JYP), also has efficacy in syndrome. Methods: Neo4j was to construct a graph database based three diseases mechanism JYP; PPI data were analyze depression process; entity grammar system resolve JYP treatment two diseases. Results: A disease charts constructed. The...