A5024901637- Receptor Mechanisms and Signaling
- Nanoplatforms for cancer theranostics
- Nicotinic Acetylcholine Receptors Study
- Cardiovascular Effects of Exercise
- Prostate Cancer Treatment and Research
- Neuropeptides and Animal Physiology
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- Estrogen and related hormone effects
- Cardiac Arrest and Resuscitation
- Photoreceptor and optogenetics research
- Synthesis and biological activity
- Sports injuries and prevention
- Cancer, Stress, Anesthesia, and Immune Response
- Laser Applications in Dentistry and Medicine
University of Washington
2024
State Key Laboratory of Biotherapy
2015
Sichuan University
2015
Abstract Breast carcinoma is the most common female cancer with considerable metastatic potential. Signal transducers and activators of transcription 3 (Stat3) signaling pathway constitutively activated in many cancers including breast has been validated as a novel potential anticancer target. Here, we reported our finding nifuroxazide, an antidiarrheal agent identified potent inhibitor Stat3. The potency nifuroxazide on was assessed vitro vivo . In this investigation, found that decreased...
Prostate cancer (PC) develops in a microenvironment where the stromal cells modulate adjacent tumor growth and progression. Here, we demonstrated elevated levels of monoamine oxidase B (MAOB), mitochondrial enzyme that degrades biogenic dietary monoamines, human PC stroma, which was associated with poor clinical outcomes patients. Knockdown or overexpression MAOB prostate fibroblasts indicated promotes cocultured cell proliferation, migration, invasion co-inoculated mice. Mechanistically,...
Abstract Introduction Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited associated with arrhythmias and increased risk of sudden cardiac death. Currently, there are no approved treatments that address the underlying genetic cause this disease, representing a significant unmet need. Purpose Mutations in desmosome gene Plakophilin-2 (PKP2) account for approximately 40% ARVC cases result reduced expression. Our goal to examine feasibility efficacy restoration PKP2...