A5100695655- Lipoproteins and Cardiovascular Health
- Immune Response and Inflammation
- Hearing, Cochlea, Tinnitus, Genetics
- Aquaculture disease management and microbiota
- Antimicrobial Peptides and Activities
- Invertebrate Immune Response Mechanisms
- Acute Myocardial Infarction Research
- Hearing Loss and Rehabilitation
- Neurobiology and Insect Physiology Research
- RNA regulation and disease
- Lung Cancer Diagnosis and Treatment
- Bone Metabolism and Diseases
- Microplastics and Plastic Pollution
- Recycling and Waste Management Techniques
- Acupuncture Treatment Research Studies
- Wastewater Treatment and Nitrogen Removal
- NF-κB Signaling Pathways
- Neurogenesis and neuroplasticity mechanisms
- Cardiovascular Function and Risk Factors
- Lung Cancer Treatments and Mutations
- Neuropeptides and Animal Physiology
- Cognitive and developmental aspects of mathematical skills
- Erythrocyte Function and Pathophysiology
- Healthcare and Venom Research
- interferon and immune responses
Chinese PLA General Hospital
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2024
Huazhong University of Science and Technology
2022-2024
Shanxi Medical University
2016-2024
Tongji Hospital
2024
Shanxi Academy of Medical Sciences
2023-2024
State Key Laboratory of Medical Neurobiology
2022-2024
Children's Hospital of Fudan University
2022-2024
Shanghai Ninth People's Hospital
2014-2023
Shanghai Jiao Tong University
2013-2023
Glioblastoma is a highly aggressive malignant tumor of the central nervous system, but interaction between glioblastoma and different types neurons remains unclear. Here, we established co-culture model
Resina Draconis (RD) is a type of dragon's blood resin obtained from Dracaena cochinchinensis (Lour.) S.C. Chen (Yunnan, China). It has been used as medicine since ancient times by many cultures. The ethanolic extract (RDEE) was evaluated for its wound-healing activity using excision and incision wound models in rats. Group I, the control group, treated with ointment base. II, which served reference standard, moist exposed burn (MEBO). III RDEE. parameters observed were percentage...
The spinal cord possesses highly complex, finely organized cytoarchitecture guided by two dorsoventral morphogenic organizing centers. Thus, generation of human tissue in vitro is challenging. Here, we demonstrated a novel method for organoids using composite scaffolds. Specifically, the ventralizing signaling Shh agonist (SAG) was loaded into porous chitosan microsphere (PCSM), then thermosensitive Matrigel coated on surface to form microspheres with functional sustained-release SAG, termed...
Cricothyroid membrane injections and the application of a coarse fiberoptic bronchoscope (FOB) below vocal cords for topical anesthesia have number limitations certain patients. Thus, aim present observational study was to assess effect novel modified method using effective sedation drugs, remifentanil (Rem) or dexmedetomidine (Dex), during awake orotracheal intubation (AFOI). In total, 90 adult patients, who had been classified as American Society Anesthesiologists I‑II, were included in...
Podocyte injury serves an important role during the progression of diabetic nephropathy (DN). The aim this study was to investigate effects forsythoside A (FA) on high glucose (HG)-induced podocyte and identify possible mechanisms.MPC-5 podocytes were cultured under HG conditions. After exposure different doses FA, cell viability apoptosis respectively evaluated with CCK-8 assay flow cytometry. Then, levels oxidative stress-related markers inflammatory factors examined by corresponding kits....
Adeno-associated virus (AAV)-based gene therapy has been demonstrated to be extremely effective for treating genetic hearing loss over the past several years. However, successful therapies hereditary deafness have not well-studied in adult mice. To explore possibility of after peripheral auditory maturity, we used AAV8 express vesicular glutamate transporter 3 (Vglut3) cochleae 5w, 8w, and 20w Vglut3KO Results indicated that AAV8-Vglut3 could mediate exogenous expression Vglut3 all inner...
Abstract Isoforms of a gene may contribute to diverse biological functions. In the cochlea, repertoire alternative isoforms remains unexplored. We integrated single-cell short-read and long-read RNA sequencing techniques identified 236,012 transcripts, 126,612 which were unannotated in GENCODE database. Then we analyzed verified transcripts using RNA-seq, RT-PCR, Sanger sequencing, MS-based proteomics approaches. To illustrate importance identifying spliced isoforms, investigated otoferlin,...
Background/Aims: High-altitude polycythemia is defined by the increase of hematocrit and hemoglobin at high altitudes caused production excessive erythrocytes. Eryptosis a process which mature erythrocytes undergo self-destruction sharing several features with apoptosis. However, eryptosis in high-altitude hypobaric hypoxia unknown. Thus, main purpose this study was to investigate whether chronic affected and, if so, what mechanisms. Methods: Biotin labeling technology utilized survival red...
BackgroundLipoprotein (a) [Lp(a)] is a causal risk factor for cardiovascular diseases, while its role in vascular calcification has not been well-established. Here, we investigated an association of Lp(a) with using population-based and vitro study designs.MethodsA total 2806 patients who received coronary computed tomography were enrolled to assess the correlation severity artery (CAC). Human aortic smooth muscle cells (HASMCs) used explore mechanisms Lp(a)-induced calcification.ResultsIn...
Dendrolimus punctatus Walker is a serious pest affecting conifers in southern China. As extensive pesticide spraying currently required to control D. punctatus, new strategies are urgently needed. Chemosensory genes represent potential molecular targets for development of alternative strategies, and the expression characteristics these provide an indication their function. To date, little information available regarding chemosensory or profiles at different stages various tissues. Here, we...
It is abundantly clear that tumor-derived parathyroid hormone-related protein (PTHrP), receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) are central contributors in promoting osteolytic process breast carcinoma bone metastasis. Forcusing on this molecular basis, the study was undertaken to explore inhibition effects total flavonoids from Scutellaria barbata D. Don (TF-SB) human MDA-MB-231 cells nude mouse models cancer metastasis were given TF-SB different...
To better understand and overcome the lithium (Li) dendrite problem in Li metal batteries, great efforts have been made to reveal growth processes using various imaging modalities. However, because of being almost invisible electrons X-rays, directly with required contrast spatial temporal resolutions has always challenge. Here, we show that, by exploiting photoacoustic effect, microscale-resolution three-dimensional structure protrusions inside glass fiber separator a Li/Li liquid...
Continuous refinement of atherosclerotic cardiovascular disease (ASCVD) stratification has raised the definition very-high-risk (VHR) recently, which been underutilized in China. We aimed to identify patients at VHR and evaluate their performances a Chinese population.A total 9944 with ASCVD was continuously enrolled. Patients identified according 2018 AHA/ACC guideline. Median follow-up 36.4 months. Clinical characteristics, low-density lipoprotein cholesterol (LDL-C) achievements,...