A5100616957- Neonatal Respiratory Health Research
- Organometallic Complex Synthesis and Catalysis
- Carbon dioxide utilization in catalysis
- Nanoplatforms for cancer theranostics
- Congenital Diaphragmatic Hernia Studies
- Autophagy in Disease and Therapy
- Asymmetric Hydrogenation and Catalysis
- Tumors and Oncological Cases
- Advanced Polymer Synthesis and Characterization
- CRISPR and Genetic Engineering
- Medical Imaging and Pathology Studies
- Ferroptosis and cancer prognosis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hematopoietic Stem Cell Transplantation
- Aquaculture disease management and microbiota
- Polymer crystallization and properties
- Nanoparticle-Based Drug Delivery
- IL-33, ST2, and ILC Pathways
- Effects of Environmental Stressors on Livestock
- Traditional and Medicinal Uses of Annonaceae
- Pluripotent Stem Cells Research
- Fatty Acid Research and Health
- Marine animal studies overview
- Microplastics and Plastic Pollution
- Bacteriophages and microbial interactions
Institute of Hydrobiology
2013-2025
Chinese Academy of Sciences
2013-2025
Zhengzhou University
2024-2025
Fuyang Normal University
2024-2025
State Key Laboratory of Polymer Physics and Chemistry
2020-2024
Changchun Institute of Applied Chemistry
2020-2024
Institute of Hematology & Blood Diseases Hospital
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
University of Science and Technology of China
2020-2024
Shanghai University of Traditional Chinese Medicine
2024
We engineered an ultrasensitive reporter of
Hydrocarbons, when used as the medium for transition metal catalyzed organic reactions and olefin (co-)polymerization, are ubiquitous. Environmentally friendly water is highly attractive long-sought, but greatly challenging coordination-insertion copolymerization reaction of polar monomers. Unfavorable interactions from both monomer usually lead to either catalyst deactivation or formation low-molecular-weight polymers. Herein, we develop well-behaved neutral phosphinophenolato nickel...
Five new alkyl zinc complexes supported by different formylfluorenimide ligands were prepared and characterized.
Pluripotent stem cells, including induced pluripotent and embryonic cells (ESCs), have less developed mitochondria than somatic and, therefore, rely more heavily on glycolysis for energy production.Citation1-3 However, how mitochondrial homeostasis matches the demands of nuclear reprogramming regulates pluripotency in ESCs is largely unknown. Here, we identified ATG3-dependent autophagy as an executor both remodeling during cell regulation ESCs. Dysfunctional by Atg3 deletion inhibited...
GWAS have repeatedly mapped susceptibility loci for emphysema to genes that modify hedgehog signaling, but the functional relevance of signaling this morbid disease remains unclear. In current study, we identified a broad population mesenchymal cells in adult murine lung receptive characterized by higher activation surrounding proximal airway relative distal alveoli. Single-cell RNA-sequencing showed hedgehog-receptive mesenchyme is composed mostly fibroblasts with distinct and subsets...
An effective shielding of both apical positions a neutral Ni
Abstract Autophagy-mediated mitochondrial degradation plays pivotal roles in both the acquisition and maintenance of pluripotency, but molecular mechanisms that link autophagy-mediated homeostasis to pluripotency regulation are unclear. Here, we identified mitophagy receptor BNIP3 regulates pluripotency. In mouse ESCs, depletion caused accumulation aberrant mitochondria accompanied by decreased membrane potential, increased production reactive oxygen species (ROS), reduced ATP generation,...
Methyl siloxanes, which belong to organic silicon compounds and have linear cyclic structures, are of particular concern because their potential characteristic persistent, bioaccumulated, toxic, ecological harm. This study investigated the trophic transfer four methyl siloxanes (octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5), dodecamethylcyclohexasiloxane (D6), tetradecamethylcycloheptasiloxane (D7)) in a marine food web from coastal area Northern China. Trophic...
Embryonic stem cells (ESCs) can propagate in an undifferentiated state indefinitely culture and retain the potential to differentiate into any somatic lineage as well germ cells. The catabolic process autophagy has been reported be involved ESC identity regulation, but underlying mechanism is still largely unknown. Here we show that EPG5, a eukaryotic-specific regulator which mediates autophagosome/lysosome fusion, highly expressed ESCs contributes maintenance. We identify deubiquitinating...
Olefin polymerization that produces the world's most important plastic by scale is one of chemical reactions. Heteroatom-containing polar compounds are usually detrimental to olefin because they prone deactivate catalysts. In this contribution, we now report a desirable positive effect solvents in ethylene polymerization. Key finding sandwich-like neutral salicylaldiminato nickel catalyst combination 8-arylnaphthyl and dibenzosuberyl groups. comparison with toluene xylene as hydrocarbon...
ABSTRACT A series of rare‐earth metal alkyl complexes containing chiral cyclohexyl‐bridged bis( β ‐diketiminate) ligands have been synthesized, with a general chemical formula {Cy[NC (Me)CHC (Me)NAr] 2 }RECH SiMe 3 [Cy=(1R, 2R)‐(‐)‐1,2‐cyclohexyl, Ar=2,6‐ i Pr C 6 H , RE=Dy( 1 ), Er( Yb( Y( 4 )]. These compounds were prepared in good yields by the reaction RE[CH ] (THF) Cy[NHC ( L ). Comprehensive characterizations all achieved through spectroscopic methods and elemental analysis. The...
Traditional thrombolytic therapy is limited by low specificity, uncontrollable bleeding complications, and secondary vascular re-embolism. To address this issue, we developed a thrombin-responsive sequential targeted nanoplatform (MMSN-UK/TI@pep-Fuco) for efficient thrombolysis based on the attack-defense-protection integrated strategy. Herein, multilevel mesoporous silica nanoparticle with multiple pore sizes was synthesized modified fucoidan (Fuco) using compound peptide (pep) as bridge to...
As the analogues of classical α-diimine nickel catalysts, pyridine-imine catalysts are great interest for olefin polymerization to produce low molecular weight and branched polyethylenes. In this contribution, complexes Ni1-Ni4 bearing dibenzhydryl- pentiptycenyl-N-aryl substituents H- Me-imine backbones were synthesized systematically studied ethylene polymerization. X-ray diffraction studies revealed that Ni1, Ni2 Ni4 adopted a monoligated/binuclear structure, while Ni3 was found adopt...
Five new alkylaluminum complexes with different pyridinyl-substituted imines or cyclohexyl-substituted were synthesized and characterized successfully.
Abstract Limited numbers of available hematopoietic stem cells (HSCs) limit the widespread use HSC-based therapies. Expansion systems for functional heterogenous HSCs remain to be optimized. Here, we present a convenient strategy human HSC expansion based on biomimetic Microniche. After demonstrating from different sources, find that our Microniche-based system expands therapeutically attractive megakaryocyte-biased HSC. We demonstrate scalable by applying this in stirred bioreactor....