A5082101942- Helicobacter pylori-related gastroenterology studies
- Viral gastroenteritis research and epidemiology
- Clostridium difficile and Clostridium perfringens research
- Neonatal Respiratory Health Research
- Global Health and Surgery
- IL-33, ST2, and ILC Pathways
- Biomedical and Engineering Education
- Genetics, Bioinformatics, and Biomedical Research
- Global Health Care Issues
- Infant Nutrition and Health
- Telomeres, Telomerase, and Senescence
- Congenital Diaphragmatic Hernia Studies
- Immune Response and Inflammation
- Eosinophilic Esophagitis
- Immunotherapy and Immune Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Listeria monocytogenes in Food Safety
- Chronic Obstructive Pulmonary Disease (COPD) Research
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
University of California, San Francisco
2022-2024
Tufts University
2022
University of California System
2022
University of California, Berkeley
2020
Cardiovascular Institute Hospital
2020
We engineered an ultrasensitive reporter of
The appearance of senescent cells in age-related diseases has spurred the search for compounds that can target tissues ("senolytics"). However, a major caveat with current senolytic screens is use cell lines as targets where senescence induced vitro, which does not necessarily reflect identity and function pathogenic vivo. Here, we developed new pipeline leveraging fluorescent murine reporter allows isolation quantification p16Ink4a+ diseased tissues. By high-throughput screening precision...
Listeria monocytogenes is a facultative intracellular bacterial pathogen that escapes from phagosomes and induces robust adaptive immune response in mice, while mutants unable to escape fail induce suppress the immunity wildtype bacteria when co-administered. The capacity can be reversed by blocking IL-10. In this study, we sought understand host receptors lead secretion of IL-10 phagosome-confined L. (Δhly), with ultimate goal generating strains We conducted transposon screen identify Δhly...
Clostridioides difficile is an important nosocomial pathogen that causes severe diarrhea by producing toxins and transmits disease spores. While both processes are crucial for C. disease, only a subset of cells express and/or undergo sporulation.
SUMMARY Group 2 innate lymphoid cells (ILC2s) cooperate with adaptive Th2 as key organizers of tissue type immune responses, while a spectrum and lymphocytes coordinate early 3/17 immunity. Both lymphocyte associated cytokines are linked to fibrosis, but how their dynamic spatial topographies may direct beneficial or pathologic organ remodelling is unclear. Here we used volumetric imaging in models liver finding accumulation periportal fibrotic tract IL-5 + lymphocytes, predominantly ILC2s,...
Abstract Senescent cells are recognized drivers of aging-related decline in organ function, but deciphering the biology senescence vivo has been hindered by paucity tools to track and isolate senescent tissues 1–4 . Deleting from transgenic murine models have demonstrated therapeutic benefits numerous age-related diseases 5–11 , identity, behavior, function deleted remain elusive. We engineered an ultra-sensitive reporter p16 INK4a a biomarker 12 + Surprisingly, mesenchymal appear basement...
Science education and research have the potential to drive profound change in low- middle-income countries (LMICs) through encouraging innovation, attracting industry, creating job opportunities. However, LMICs, capacity is often limited, acquisition of funding access state-of-the-art technologies challenging. The Alliance for Global Health (the Alliance) was founded as a partnership between University California, Berkeley (USA) Makerere (Uganda), with goal strengthening University's...
ABSTRACT The bacterial pathogen Clostridioides difficile causes gastroenteritis through its production of toxins and transmits disease resistant spores. Toxin spore are energy-expensive processes that regulated by multiple transcription factors in response to many nutritional inputs. While toxin sporulation genes both heterogeneously expressed only a subset C. cells, the relationship between these two sub-populations remains unclear. To address whether coordinates generation sub-populations,...