A5101496940- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Surgical Treatments
- Genomics, phytochemicals, and oxidative stress
- Venous Thromboembolism Diagnosis and Management
- Colorectal Cancer Screening and Detection
- Digital Innovation in Industries
- Gastric Cancer Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Ethics in medical practice
- Meningioma and schwannoma management
- Immune Cell Function and Interaction
- Glioma Diagnosis and Treatment
- Regulation of Appetite and Obesity
- Enhanced Recovery After Surgery
- Skin Protection and Aging
- T-cell and B-cell Immunology
- Atrial Fibrillation Management and Outcomes
- Nonmelanoma Skin Cancer Studies
- Inflammatory Bowel Disease
- Colorectal Cancer Treatments and Studies
- Diverticular Disease and Complications
- Facial Nerve Paralysis Treatment and Research
- CAR-T cell therapy research
- Glutathione Transferases and Polymorphisms
- Hepatocellular Carcinoma Treatment and Prognosis
Universitätsklinikum Würzburg
2017-2024
Universitäts-Kinderklinik Würzburg
2017-2024
University of California, San Francisco
2020-2023
Ludwig-Maximilians-Universität München
2017-2023
LMU Klinikum
2022-2023
University of Würzburg
2016-2022
Klinik für Frauenheilkunde
2021
Philipps University of Marburg
2017
Heidelberg University
2007-2014
University Hospital Heidelberg
2007-2014
Inflammation and dysfunction of the extrahepatic biliary tree are common causes human pathology, including gallstones cholangiocarcinoma. Despite this, we know little about local regulation inflammation. Tuft cells, rare sensory epithelial particularly prevalent in mucosa gallbladder bile ducts. Here, show that tuft cells express a core genetic cell program addition to tissue-specific gene signature and, contrast small intestinal decreased postnatally, coincident with maturation acid...
Abstract Background The impact of hospital volume after rectal cancer surgery is seldom investigated. This study aimed to analyse the annual cases per on postoperative mortality and failure rescue. Methods All patients diagnosed with who had a resection procedure code from 2012 2015 were identified nationwide administrative data. Hospitals grouped into five quintiles according caseload. absolute number patients, deaths rescue (defined as in-hospital documented complication) for severe...
Alloantigen-specific regulatory T cell (Treg) therapy is a promising approach for suppressing alloimmune responses and minimizing immunosuppression after solid organ transplantation. Chimeric antigen receptor (CAR) targeting donor alloantigens can confer reactivity to Tregs. However, CAR Treg has not been evaluated in vascularized transplant or multi-MHC mismatched models. Here, we the ability of Tregs HLA-A2 (A2-CAR) prolong survival heterotopic heart transplants mice. After verifying vitro...
Colonic cancer is the most common of gastrointestinal tract. The aim this study was to determine mortality rates following colonic resection and effect hospital caseload on in-hospital in Germany. Patients admitted with a diagnosis undergoing from 2012 2015 were identified nationwide registry using procedure codes. outcome measure mortality. Hospitals ranked according their for resection, patients categorized into five subgroups basis volume. Some 129 196 resections reviewed. overall...
Abstract Background and Aims Despite recent advancements in medical surgical techniques patients suffering from Crohn`s disease [CD], postoperative morbidity remains relevant due to a long-standing, non-curable burden. As demonstrated for oncological patients, perioperative enhanced recovery concepts provide great potential improve outcome. However, robust evidence about the effect of specific cohort CD is lacking. Methods In prospective, single-centre study, all receiving ileocaecal...
Abstract Background Preoperative chemoradiotherapy is the recommended standard of care for patients with local advanced rectal cancer. However, it remains unclear, whether a prolonged time interval to surgery results in an increased perioperative morbidity, reduced TME quality or better pathological response. Aim this study was determine best response and outcome compared current 6 8 weeks. Methods This retrospective analysis German StuDoQ|Rectalcarcinoma registry. Patients were grouped...
Background 40–50% of patients with colorectal cancer (CRC) will develop liver metastases (CRLM) during the course disease. One third these additionally pulmonary metastases. Methods 137 consecutive CRLM, were analyzed regarding survival data, clinical, histological data and treatment. Results stratified according to occurrence resection. 39% all resection due CRLM developed additional lung 44% underwent subsequent Patients undergoing metastasectomy showed a significantly better five-year...
To evaluate the long-term outcome of patients with vestibular schwannoma (VS) and neurofibromatosis type 2 (NF2) treated fractionated stereotactic radiotherapy (FSRT) or radiosurgery (SRS).Sixteen VS in 14 NF2 were FSRT (n = 14) SRS 2). Patients tumor progression and/or clinical symptoms selected for treatment. For a median total dose 57.6 Gy was prescribed fractionation 5 × 1.8 per week. who underwent single 17 to 80% isodose.FSRT well tolerated. Local control rate 94% follow-up time 131...
To evaluate the long-term outcome of patients with vestibular schwannoma (VS) and neurofibromatosis type 2 (NF2) treated fractionated stereotactic radiotherapy (FSRT) or radiosurgery (SRS).Sixteen VS in 14 NF2 were FSRT (n = 14) SRS 2). Patients tumor progression and/or clinical symptoms selected for treatment. For a median total dose 57.6 Gy was prescribed fractionation 5 × 1.8 per week. who underwent single 17 to 80% isodose.FSRT well tolerated. Local control rate 94% follow-up time 131...
SUMMARY Group 2 innate lymphoid cells (ILC2s) cooperate with adaptive Th2 as key organizers of tissue type immune responses, while a spectrum and lymphocytes coordinate early 3/17 immunity. Both lymphocyte associated cytokines are linked to fibrosis, but how their dynamic spatial topographies may direct beneficial or pathologic organ remodelling is unclear. Here we used volumetric imaging in models liver finding accumulation periportal fibrotic tract IL-5 + lymphocytes, predominantly ILC2s,...
In this study, we investigate a gene augmentation therapy candidate for the treatment of retinitis pigmentosa (RP) due to cyclic nucleotide-gated channel beta 1 (CNGB1) mutations. We use an adeno-associated virus serotype 5 with transgene under control novel short human rhodopsin promoter. The promoter/capsid combination drives efficient expression reporter (AAV5-RHO-eGFP) exclusively in rod photoreceptors primate, dog, and mouse following subretinal delivery. therapeutic vector...
Traditionally, previous wound infection was considered a contraindication to secondary skin closure; however, several case reports describe successful closure of wounds "preconditioned" with negative pressure therapy (NPWT). Although this has been increasingly applied in daily practice, systematic analysis its feasibility not published thus far. The aim study evaluate previously infected abdominal following treatment NPWT.Single-center retrospective patients treated NPWT followed by either...