A5029954495- Social and Educational Sciences
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Atherosclerosis and Cardiovascular Diseases
- Reliability and Maintenance Optimization
- Power System Reliability and Maintenance
- IL-33, ST2, and ILC Pathways
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Knowledge Management and Sharing
- Coronary Interventions and Diagnostics
- Childhood Cancer Survivors' Quality of Life
- Xenotransplantation and immune response
- Pulmonary Hypertension Research and Treatments
- Family Support in Illness
- Optical Imaging and Spectroscopy Techniques
- Diabetes Management and Education
- Educational and Psychological Assessments
- Machine Fault Diagnosis Techniques
- Immune cells in cancer
- Soil and Water Nutrient Dynamics
- Early Childhood Education and Development
- Diabetes Management and Research
University of California, San Francisco
2023-2025
Lund University
2013-2024
Malmö University
1996-2024
Autoimmune Technologies (United States)
2020
Stellenbosch University
2013
KTH Royal Institute of Technology
2007-2010
Swedish National Heritage Board
1989
Hypoxia is a major cause of pulmonary hypertension (PH) worldwide, and it likely that interstitial macrophages contribute to this vascular pathology. We observed in hypoxia-exposed mice an increase resident macrophages, which expanded through proliferation expressed the monocyte recruitment ligand CCL2. also CCR2+ recruitment, express protein thrombospondin-1 functionally activates TGF-beta disease. Blockade with either CCL2 neutralizing antibody treatment or CCR2 deficiency bone marrow...
Objectives. To describe the size, overlap and mortality of four cardiovascular risk groups, in order to give a scientific background for prevention disease representative urban population. Setting. Section Preventive Medicine, Department Malmö University Hospital, Malmö, Sweden. Subjects. Between 1974 1984 22444 men born between 1949 1921, constituting 75% total male population these age took part comprehensive screening examination aimed at detecting factors disease. Interventions. Those...
Obesity is associated with glucose intolerance and insulin resistance closely linked to the increasing prevalence of type 2 diabetes. In mouse models diet-induced obesity (DIO) diabetes, an increased fat intake results in adipose tissue expansion secretion proinflammatory cytokines. The innate immune system not only plays a crucial role obesity-associated chronic low-grade inflammation but it also proposed play modulating energy metabolism. However, little known about how modulation...
In recent years, three-dimensional mesoscopic imaging has gained significant importance in life sciences for fundamental studies at the whole-organ level. this manuscript, we present an optical projection tomography (OPT) method designed of intact mouse brain. The system features isotropic resolution ~50 µm and acquisition time four to eight minutes, using a 3-day optimized clearing protocol. Imaging brain autofluorescence 3D reveals details neuroanatomy, while use fluorescent labels...
Quinoline-3-carboxamides (Q substances) are small molecule compounds with anti-inflammatory properties. In this study, we used one of these substances, Paquinimod, to treat a novel model for chronic liver inflammation and fibrosis, the NOD-Inflammation Fibrosis (N-IF) mouse. We show that treatment N-IF mice significantly reduced resulted in regression even when was initiated after onset disease. The disease phenotype associated systemic decrease number activation disease-promoting transgenic...
Abstract Aims Quantitative computed tomography (QCT) allows assessment of morphological features coronary atherosclerosis. We aimed to test the hypothesis that clinical patient presentation is associated with distinct Methods and results A total 1652 participants, representing a spectrum risk profiles [787 asymptomatic individuals from general population, 468 patients acute chest pain without syndrome (ACS), 397 ACS], underwent multidetector tomography. Of these, 274 individuals, 254 ACS,...
The large growth in the wind power industry past years mainly focuses on a growing market and development of turbines offshore farms. high technical availability comes with need for frequent maintenance. Current maintenance planning is generally not optimized, it possible to make more efficient. Condition Monitoring Systems (CMS) are commonly used other industries can reduce consequential damage at failure provides advantages It interest determine if would benefit use CMS. This paper shows...
Sterile liver inflammation and fibrosis are associated with many disorders of different etiologies. Both type 1 2 inflammatory responses have been reported to contribute pathology. However, the mechanisms controlling balance between these largely unknown. Natural killer T (NKT) cells can be activated rapidly secrete cytokines chemokines both responses. As proteins accumulate in types sterile inflammation, we hypothesized that may play a role this pathological process. We found transgenic NKT...
It is well established that subjects with moderately elevated plasma levels of C-reactive protein (CRP) have an increased risk development cardiovascular events. As atherosclerosis a disease characterized by chronic arterial inflammation, it possible moderate increases in CRP level reflect the presence plaque inflammation. To investigate this possibility, we compared hsCRP day before carotid endarterectomy degree inflammation excised tissue.Luminex immunoassays were used to determine IL-6,...
Abstract Background CD31 is a membrane receptor expressed by leucocytes, platelets and endothelial cells. regulates leukocyte transmigration key in maintaining homeostasis. An increased activation suggested to contribute atherosclerotic plaque inflammation but studies focusing on atherosclerosis have provided evidence for both pro- anti-atherosclerotic effects. However, which biological processes that are reflected circulating soluble (sCD31) human remain unknown. Purpose Here, we aimed...
Monocyte-derived macrophages recruited to injured tissues induce a maladaptive fibrotic response characterized by excessive production of collagen local fibroblasts. Macrophages initiate this programming via paracrine factors, but it is unknown whether reciprocal responses from fibroblasts enhance profibrotic polarization macrophages. We identify macrophage-fibroblast crosstalk necessary for injury-associated fibrosis, in which induced interleukin 6 (
Nuclear power is one of the main electricity production sources in Sweden today. Maintenance management tool for reducing costs operation a plant. Driving forces cost-efficiency has pushed development new methods maintenance planning and optimization forward. Reliability Centered Asset Management (RCAM) these approaches, way to perform quantitative analysis which feature RCAM. This paper proposes model opportunistic where replacement schedules shaft seals feed-water pump systems nuclear...
Here we characterize a new animal model that spontaneously develops chronic inflammation and fibrosis in multiple organs, the non-obese diabetic (N-IF) mouse. In liver, N-IF mouse displays particularly evident around portal tracts central veins accompanied with evidence of abnormal intrahepatic bile ducts. The extensive cellular infiltration consists mainly macrophages, granulocytes, eosinophils, mast cells. This inflammatory syndrome is mediated by transgenic population natural killer T...
Background Schistosomiasis is a common cause of pulmonary hypertension (PH) worldwide. Type 2 inflammation contributes to the development Schistosoma-induced PH. Specifically, interstitial macrophages (IMs) derived from monocytes play pivotal role by producing thrombospondin-1 (TSP-1), which in turn activates TGF-β, thereby driving pathology Resident and recruited IM subpopulations have recently been identified. We hypothesized that Schistosoma-PH, one subpopulation expresses monocyte...
Metabolic dysfunction-associated steatohepatitis (MASH) is a common but frequently unrecognized complication of obesity and type 2 diabetes. The association between these conditions multifaceted involves complex interactions metabolic, inflammatory, genetic factors. Here we assess the underlying structural molecular processes focusing on immunological phase MASH in nonobese inflammation fibrosis (NIF) mouse model compare it to human disease as well other murine models. Histopathology...
SUMMARY Group 2 innate lymphoid cells (ILC2s) cooperate with adaptive Th2 as key organizers of tissue type immune responses, while a spectrum and lymphocytes coordinate early 3/17 immunity. Both lymphocyte associated cytokines are linked to fibrosis, but how their dynamic spatial topographies may direct beneficial or pathologic organ remodelling is unclear. Here we used volumetric imaging in models liver finding accumulation periportal fibrotic tract IL-5 + lymphocytes, predominantly ILC2s,...
The large growth in the wind power industry past years mainly focuses on a growing market and development of turbines offshore farms. high technical availability comes with need for frequent maintenance. Current maintenance planning is not optimized, it possible to make more efficient. Condition monitoring systems (CMS) could resolve industry's better management increased reliability. Such are commonly used other industries. CMS continuously monitor turbine parts performance, help determine...
In diabetes, pancreatic β-cells play a key role.These cells are clustered within structures called islets of Langerhans inside the pancreas and produce insulin, which is directly secreted into blood stream.The dense vascularization critical for maintaining proper regulation glucose homeostasis known to be affected from early stage diabetes.The deep localization these in abdominal cavity renders their vivo visualization challenging task.A fast label-free imaging method with high spatial...
Abstract Aims/hypothesis Rapid and adequate islet revascularisation restoration of the islet–extracellular matrix (ECM) interaction are significant factors influencing survival function transplanted islets in individuals with type 1 diabetes. Because ECM encapsulating is degraded during isolation, understanding process engraftment after transplantation essential needs further investigation. Methods Here we apply a longitudinal high-resolution imaging approach to investigate dynamics...
Although the plant and animal kingdoms were separated more than 1,6 billion years ago, multicellular development is for both guided by similar transcriptional, epigenetic posttranscriptional machinery. One may ask to what extent there are similarities differences in gene regulation circuits their dynamics when it comes important processes like stem cell regulation. The key players mouse embryonic cells governing pluripotency versus differentiation Oct4, Sox2 Nanog. Correspondingly, WUSCHEL...
Imaging beta cells is a key step towards understanding islet transplantation. Although different imaging platforms for the recording of cell biology have been developed and utilized in vivo, they are limited terms allowing single resolution continuous longitudinal recordings. Because transparency cornea, anterior chamber eye (ACE) mice well suited to study human mouse pancreatic biology. Here description how this approach can be used perform recordings grafting revascularization individual...