A5057651852- Adipose Tissue and Metabolism
- 3D Printing in Biomedical Research
- Mitochondrial Function and Pathology
- Immune cells in cancer
- Endoplasmic Reticulum Stress and Disease
- ATP Synthase and ATPases Research
- Genetics, Aging, and Longevity in Model Organisms
- Exercise and Physiological Responses
- Tissue Engineering and Regenerative Medicine
- RNA modifications and cancer
- Cellular Mechanics and Interactions
- Extracellular vesicles in disease
- Phagocytosis and Immune Regulation
- Cancer Immunotherapy and Biomarkers
- Spaceflight effects on biology
- Cancer Cells and Metastasis
- Electrospun Nanofibers in Biomedical Applications
- Global Cancer Incidence and Screening
- Signaling Pathways in Disease
- Ubiquitin and proteasome pathways
- Heat shock proteins research
- Glycosylation and Glycoproteins Research
- Liver Disease Diagnosis and Treatment
- Neuropeptides and Animal Physiology
- Epigenetics and DNA Methylation
Indiana University Bloomington
2024
Discovery Institute
2024
Sanford Burnham Prebys Medical Discovery Institute
2024
University of California, San Francisco
2018-2024
Indiana University – Purdue University Indianapolis
2021
University of California, Berkeley
2014-2018
Berkeley College
2017
University of Portland
2011
Oregon Health & Science University
2010
Organs-on-a-chip possess a promising future as drug screening assays and testbeds for disease modeling in the context of both single-organ systems multi-organ-chips.
Zfp516, a brown fat (BAT)-enriched and cold-inducible transcription factor, promotes of UCP1 other BAT-enriched genes for non-shivering thermogenesis. Here, we identify lysine-specific demethylase 1 (LSD1) as direct binding partner Zfp516. We show that, through interaction with LSD1 is recruited to genes, such PGC1α, function coactivator by demethylating H3K9. also that induced during adipogenesis its activity required the BAT program. Furthermore, ablation in mice using Myf5-Cre alters...
Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most prevalent types of primary liver cancer. These malignancies have limited treatment options, resulting in poor patient outcomes. Metabolism reprogramming, including increased de novo lipogenesis, is one hallmarks Fatty acid synthase (FASN) catalyzes synthesis long‐chain fatty acids from acetyl‐coenzyme A malonyl‐coenzyme A. Increased FASN expression has been reported multiple tumor types, inhibition shown to...
Novel, clinically relevant, approaches to shift energy balance are urgently needed combat metabolic disorders such as obesity and diabetes. One promising approach has been the expansion of brown adipose tissues that express uncoupling protein (UCP) 1 thus can uncouple mitochondrial respiration from ATP synthesis. While UCP1-expressing depots may be achieved in rodents via genetic pharmacological manipulations or transplantation fat depots, these methods difficult use for human clinical...
To determine the metabolic effects of grapefruit juice consumption we established a model in which C57Bl/6 mice drank 25–50% sweetened GFJ, clarified larger insoluble particles by centrifugation (cGFJ), ad libitum as their sole source liquid or isocaloric and water. cGFJ control groups consumed similar amounts liquids calories. Mice fed high-fat diet experienced 18.4% decrease weight, 13–17% fasting blood glucose, three-fold serum insulin, 38% liver triacylglycerol values, compared to...
Coordinated gastrointestinal smooth muscle contraction is critical for proper nutrient absorption and altered in a number of medical disorders. In this work, we demonstrate role the RGD-binding integrin α8β1 promoting through regulation motility. Smooth muscle-specific deletion antibody blockade α8 mice result enhanced gastric antral contraction, more rapid emptying, transit food small intestine leading to malabsorption dietary fats carbohydrates as well protection from weight gain...
Pre-metastatic niche formation is a critical step during the metastatic spread of cancer. One way by which primary tumors prime host cells at future sites through shedding tumor-derived microparticles as consequence vascular sheer flow. However, it remains unclear how uptake such particles resident immune affects their phenotype and function. Here, we show that ingestion macrophages induces rapid metabolic phenotypic switch characterized enhanced mitochondrial mass function, increased...
Gallstone disease is a widespread disorder costing billions for annual treatment in the United States. The primary mechanisms underlying gallstone formation are biliary cholesterol supersaturation and gallbladder hypomotility. relative contribution of these two processes has been difficult to dissect, as experimental lithogenic diets cause both bile alterations motility. Importantly, there no mechanistic explanation obesity major risk factor cholelithiasis. We discovered that induce ectopic...
Monocyte-derived macrophages recruited to injured tissues induce a maladaptive fibrotic response characterized by excessive production of collagen local fibroblasts. Macrophages initiate this programming via paracrine factors, but it is unknown whether reciprocal responses from fibroblasts enhance profibrotic polarization macrophages. We identify macrophage-fibroblast crosstalk necessary for injury-associated fibrosis, in which induced interleukin 6 (