A5075298581- Nuclear Structure and Function
- RNA Research and Splicing
- RNA modifications and cancer
- Cell Adhesion Molecules Research
- RNA regulation and disease
- Asthma and respiratory diseases
- Muscle Physiology and Disorders
- Phagocytosis and Immune Regulation
- Trace Elements in Health
- PI3K/AKT/mTOR signaling in cancer
- Mitochondrial Function and Pathology
- Caveolin-1 and cellular processes
- Cellular Mechanics and Interactions
- Bone and Dental Protein Studies
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Ginger and Zingiberaceae research
- Peroxisome Proliferator-Activated Receptors
- Immune cells in cancer
- Gastrointestinal motility and disorders
- Metabolism, Diabetes, and Cancer
- Infant Nutrition and Health
Discovery Institute
2017-2023
Sanford Burnham Prebys Medical Discovery Institute
2017-2023
National Cancer Institute
2021
University of California, San Francisco
2012-2016
Meiji (Japan)
2015
Airway obstruction is a hallmark of allergic asthma and caused primarily by airway smooth muscle (ASM) hypercontractility. inflammation leads to the release cytokines that enhance ASM contraction increasing ras homolog gene family, member A (RhoA) activity. The protective mechanisms prevent or attenuate increase in RhoA activity have not been well studied. Here, we report mice lacking encodes protein Milk Fat Globule-EGF factor 8 ( Mfge8 −/− ) develop exaggerated hyperresponsiveness...
Coordinated gastrointestinal smooth muscle contraction is critical for proper nutrient absorption and altered in a number of medical disorders. In this work, we demonstrate role the RGD-binding integrin α8β1 promoting through regulation motility. Smooth muscle-specific deletion antibody blockade α8 mice result enhanced gastric antral contraction, more rapid emptying, transit food small intestine leading to malabsorption dietary fats carbohydrates as well protection from weight gain...
Summary Irritable bowel syndrome ( IBS ) is a prevalent disease characterized by abdominal pain and abnormal habits. Pioglitazone peroxisome proliferator‐activated receptor PPAR γ agonist and, although it mostly used as an antidiabetic agent, has been reported to have analgesic effects. Nitric oxide NO ), gaseous molecule that mediates many of the effects pioglitazone, implicated in pathophysiology . The aim present study was investigate pioglitazone on symptoms rat model...
Tissue fibrosis occurs when matrix production outpaces degradation. Degradation of collagen, the main component fibrotic tissue, is mediated through an extracellular proteolytic pathway and intracellular cellular uptake lysosomal digestion. Recent studies demonstrate that disruption pathways can exacerbate fibrosis. These are poorly characterized. Here we identify novel mediators collagen turnover a genome-wide RNA interference screen in Drosophila S2 cells. Screening 7505 genes conserved...
Nuclear pore complexes, the channels connecting nucleus with cytoplasm, are built by multiple copies of ∼30 proteins called nucleoporins. Recent evidence has exposed that nucleoporins can play cell type-specific functions. Despite novel discoveries into cellular functions nucleoporins, their role in regulation mammalian tissue physiology remains mostly unexplored because a limited number nucleoporin mouse models. Here we show ablation Nup210/Gp210, previously identified to myoblast...
<p>Supplementary Movie</p>
<p>Supplementary Figures and Methods</p>
<div>Abstract<p>Nuclear pore complexes (NPC) are the central mediators of nucleocytoplasmic transport. Increasing evidence shows that many cancer cells have increased numbers NPCs and become addicted to nuclear transport machinery. How reducing NPC affects physiology normal whether it could be exploited for therapies has not been investigated. We report inhibition formation, a process mostly restricted proliferating cells, causes selective cell death, prevents tumor growth,...
<p>Supplementary Figures and Methods</p>
<p>Supplementary Movie</p>
<div>Abstract<p>Nuclear pore complexes (NPC) are the central mediators of nucleocytoplasmic transport. Increasing evidence shows that many cancer cells have increased numbers NPCs and become addicted to nuclear transport machinery. How reducing NPC affects physiology normal whether it could be exploited for therapies has not been investigated. We report inhibition formation, a process mostly restricted proliferating cells, causes selective cell death, prevents tumor growth,...