A5100373357- Chronic Myeloid Leukemia Treatments
- Epilepsy research and treatment
- Asthma and respiratory diseases
- Chronic Lymphocytic Leukemia Research
- Cell Adhesion Molecules Research
- Natural Compounds in Disease Treatment
- Neonatal and fetal brain pathology
- Inflammasome and immune disorders
- Alzheimer's disease research and treatments
- Garlic and Onion Studies
- Pharmacological Effects and Toxicity Studies
- Acute Myeloid Leukemia Research
- Retinoids in leukemia and cellular processes
- Eosinophilic Disorders and Syndromes
- Respiratory Support and Mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Immune Cell Function and Interaction
- Heme Oxygenase-1 and Carbon Monoxide
- Pharmaceutical studies and practices
- Nuclear Receptors and Signaling
- GDF15 and Related Biomarkers
First Affiliated Hospital of Fujian Medical University
2024
Fujian Medical University
2024
Sun Yat-sen Memorial Hospital
2010-2021
Sun Yat-sen University
2010-2021
Guangdong Provincial Hospital of Traditional Chinese Medicine
2020
Huaian First People’s Hospital
2019
University of California, San Francisco
2006-2012
Memorial Hospital
2012
The University of Texas MD Anderson Cancer Center
2012
Chronic myelogenous leukemia (CML) is characterized by the chimeric tyrosine kinase Bcr-Abl. Bcr-Abl-T315I notorious point mutation that causes resistance to imatinib and second generation inhibitors, leading poor prognosis. CML blasts have constitutive p65 (RelA NF-kappaB) transcriptional activity, NF-kappaB may be a potential target for molecular therapies in also effective against cells with Bcr-Abl-T315I.In this report, we discovered pristimerin, quinonemethide triterpenoid isolated from...
Airway obstruction is a hallmark of allergic asthma and caused primarily by airway smooth muscle (ASM) hypercontractility. inflammation leads to the release cytokines that enhance ASM contraction increasing ras homolog gene family, member A (RhoA) activity. The protective mechanisms prevent or attenuate increase in RhoA activity have not been well studied. Here, we report mice lacking encodes protein Milk Fat Globule-EGF factor 8 ( Mfge8 −/− ) develop exaggerated hyperresponsiveness...
A disintegrin and metalloprotease 33 (ADAM33) is a transmembrane protease integrin ligand that has been identified as an asthma susceptibility gene product. To determine whether ADAM33 plays important roles in mammalian development the modulation of allergic airway dysfunction, we generated ADAM33-null mice by targeting. were born at expected Mendelian ratios, both male females developed normally fertile. No anatomical or histological abnormalities detected any tissues. In animal model...
The "gate-keeper" mutations T674I platelet-derived growth factor receptor α (PDGFRα) in hypereosinophilic syndrome (HES) and T315I Bcr-Abl chronic myeloid leukemia (CML) are resistant to imatinib the second-generation small-molecule tyrosine kinase inhibitors (TKI). However, combat acquired resistance imatinib, an alternative approach is decrease expression of addicted gene efficiently kill malignant hematologic cells. purpose this study was evaluate strategy shutting down transcription...
Alzheimer's Disease (AD), characterized by deficits in memory and cognition behavioral impairment, is a progressive neurodegenerative disorder that influences more than 47 million people worldwide. Currently, no available drug able to stop AD progression. Therefore, novel therapeutic strategies need be investigated. We analyzed the RNA sequencing data (RNA-seq) derived from Gene Expression Omnibus (GEO) database identify differentially expressed mRNAs AD. The mouse model Tg2576 was used...
Supplementary Figure 1 from Antineoplastic Mechanisms of Niclosamide in Acute Myelogenous Leukemia Stem Cells: Inactivation the NF-κB Pathway and Generation Reactive Oxygen Species