A5057866050- Quantum Chromodynamics and Particle Interactions
- Particle physics theoretical and experimental studies
- Neural Networks and Applications
- High-Energy Particle Collisions Research
- Gene expression and cancer classification
- Gene Regulatory Network Analysis
- Protein Structure and Dynamics
- Bioinformatics and Genomic Networks
- Single-cell and spatial transcriptomics
- Metaheuristic Optimization Algorithms Research
- Physics of Superconductivity and Magnetism
- Enzyme Structure and Function
- Theoretical and Computational Physics
- T-cell and B-cell Immunology
- Pluripotent Stem Cells Research
- Advanced Biosensing Techniques and Applications
- Black Holes and Theoretical Physics
- CRISPR and Genetic Engineering
- Computational Physics and Python Applications
- Electrostatics and Colloid Interactions
- semigroups and automata theory
- ECG Monitoring and Analysis
- RNA and protein synthesis mechanisms
- Material Dynamics and Properties
- Breast Cancer Treatment Studies
Lund University
2015-2024
University of Michigan
2017-2019
CREATe Centre
2011
Charité - Universitätsmedizin Berlin
2009
University of New Mexico
1997-2004
Stanford Synchrotron Radiation Lightsource
1981-2003
SLAC National Accelerator Laboratory
1981-2003
Harvard University
2002
National Institutes of Health
2001
Center for Theoretical Physics
1996-1998
The origin of the observed scaling violations in inclusive ${e}^{+}{e}^{\ensuremath{-}}$ annihilation is investigated. Perturbative jet evolution not necessarily only reason for scale breaking hadron spectra at present energies. Remnants finite-transverse-momentum and mass effects are still important nonperturbative, cascade-type, formation \ensuremath{\sim}10 GeV range. Heavy-quark fragmentation has a strong impact on hadronic spectra. A simple parametrization heavy-quark function given...
The recently measured yeast transcriptional network is analyzed in terms of simplified Boolean models, with the aim determining feasible rule structures, given requirement stable solutions generated networks. We find that, for ensembles those canalyzing rules are remarkably stable, whereas random only marginally stable. Furthermore, substantial parts networks frozen, sense that they reach same state, regardless initial state. Thus, our ensemble approach suggests shows highly ordered dynamics.
An integrated method for clustering of QRS complexes is presented which includes basis function representation and self-organizing neural networks (NN's). Each complex decomposed into Hermite functions the resulting coefficients width parameter are used to represent complex. By means this representation, unsupervised NNs employed cluster data 25 groups. Using MIT-BIH arrhythmia database, clusters found exhibit a very low degree misclassification (1.5%). The outperforms, on both published...
A novel modified method for obtaining approximate solutions to difficult optimization problems within the neural network paradigm is presented. We consider graph partition and travelling salesman problems. The key new ingredient a reduction of solution space by one dimension using graded neurons, thereby avoiding destructive redundancy that has plagued these when straightforward techniques. This approach maps onto Potts glass rather than spin theories. systematic prescription given...
We determine stability and attractor properties of random Boolean genetic network models with canalyzing rules for a variety architectures. For all power law, exponential, flat in-degree distributions, we find that the networks are dynamically stable. Furthermore, architectures few inputs per node, dynamics is close to critical. In addition, fraction genes active decreases number node. These results based upon investigating ensembles using analytical methods. Also, different numbers fixed...
The postulate that ordinary hadrons contain intrinsic charm-quark states (such as $|uudc\overline{c}〉$ in the proton) at 1% level is shown to explain two sets of unexpected experimental results: (1) copious diffractive production charmed large longitudinal momentum high-energy proton-nucleon and pion-nucleon collisions, (2) anomalously number same-sign dimuon events observed deep-inelastic neutrino reactions. We also predict cross sections for open $b$ $t$ hadron-hadron collisions.
Recent ChIP experiments of human and mouse embryonic stem cells have elucidated the architecture transcriptional regulatory circuitry responsible for cell determination, which involves transcription factors OCT4, SOX2, NANOG. In addition to regulating each other through feedback loops, these genes also regulate downstream target involved in maintenance differentiation cells. A search OCT4–SOX2–NANOG network motif species reveals that it is unique mammals. With a kinetic modeling approach, we...
Abstract Purpose: Endocrine therapies, such as tamoxifen, are commonly given to most patients with estrogen receptor (ERα)–positive breast carcinoma but not indicated for persons ERα-negative cancer. The factors responsible response tamoxifen in 5% 10% of tumors clear. aim the present study was elucidate biology and prognostic role second ER, ERβ, treated adjuvant tamoxifen. Experimental Design: We investigated ERβ by immunohistochemistry 353 stage II primary from 2 years generated gene...
Recent studies have associated the transcription factors, Oct4, Sox2 and Nanog as parts of a self-regulating network which is responsible for maintaining embryonic stem cell properties: self renewal pluripotency. In addition, mutual antagonism between two these other master regulators been shown to regulate lineage determination. particular, an excess Cdx2 over Oct4 determines trophectoderm whereas Gata-6 differentiation into endoderm lineage. Also, under/over-expression regulator revealed...
Summary Boreal trees rely on their ectomycorrhizal fungal symbionts to acquire growth‐limiting nutrients, such as nitrogen (N), which mainly occurs proteins complexed in soil organic matter ( SOM ). The mechanisms for liberating this N are unclear fungi have lost many genes encoding lignocellulose‐degrading enzymes present saprotrophic ancestors. We hypothesized that hydroxyl radicals ˙ OH ), produced by the fungus Paxillus involutus during growth , involved N. was grown 7 d N‐containing or...
We present a general method, the δ-test, which establishes functional dependencies given sequence of measurements. The approach is based on calculating conditional probabilities from vector component distances. Imposing requirement continuity underlying function, obtained values carry information embedding dimension and variable dependencies. power method illustrated synthetic time-series with different time-lag noise levels sunspot data. virtue for preprocessing data in context feedforward...
Abstract The driving force behind oncoproteomics is to identify protein signatures that are associated with a particular malignancy. Here, we have used recombinant scFv antibody microarray in an attempt classify sera derived from pancreatic adenocarcinoma patients versus healthy subjects. Based on analysis of nonfractionated, directly labeled, whole human serum proteomes identified signature based 19 nonredundant analytes, discriminates between cancer and Furthermore, potential signature,...
Hematopoietic stem cell lineage choices are decided by genetic networks that turned ON/OFF in a switch-like manner. However, prior to commitment, genes primed at low expression levels. Understanding the underlying molecular circuitry terms of how it governs both state and, other extreme, committed is relevance not only hematopoiesis but also developmental systems general. We develop computational model for hematopoietic erythroid-myeloid decision, which determined switch involving PU.1 and...