Per E. Sigvardsen
A5028277612- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Aortic aneurysm repair treatments
- HIV-related health complications and treatments
- Aortic Disease and Treatment Approaches
- Cardiovascular Issues in Pregnancy
- Liver Disease Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Pregnancy and preeclampsia studies
- Blood Pressure and Hypertension Studies
- Cardiac Structural Anomalies and Repair
- Birth, Development, and Health
- Cardiomyopathy and Myosin Studies
- Cardiovascular Disease and Adiposity
- Aortic Thrombus and Embolism
- Cardiovascular Effects of Exercise
- Infective Endocarditis Diagnosis and Management
- Cardiac electrophysiology and arrhythmias
- Medical Imaging Techniques and Applications
- Bone health and treatments
- Infectious Aortic and Vascular Conditions
- Advanced X-ray and CT Imaging
Rigshospitalet
2016-2025
Copenhagen University Hospital
2019-2025
University of Copenhagen
2016-2024
Nordsjællands Hospital
2023
Coronary atherosclerosis may develop at an early age and remain latent for many years.To define characteristics of subclinical coronary associated with the development myocardial infarction.Prospective observational cohort study.Copenhagen General Population Study, Denmark.9533 asymptomatic persons aged 40 years or older without known ischemic heart disease.Subclinical was assessed computed tomography angiography conducted blinded to treatment outcomes. characterized according luminal...
Background Coronary artery calcium (CAC) has prognostic value for major adverse cardiovascular events (MACE) in asymptomatic individuals, whereas its role symptomatic patients is less clear. Purpose To assess the of CAC scoring MACE participants with stable chest pain initially referred invasive coronary angiography (ICA). Materials and Methods This prespecified subgroup analysis from Diagnostic Imaging Strategies Patients With Stable Chest Pain Intermediate Risk Artery Disease (DISCHARGE)...
Abstract Aims The prevalence and difference in risk factors for having thoracic aortic aneurysm (TAA) abdominal (AAA) men compared with women the general population is not well described. This study aimed to test hypotheses that (i) cardiovascular TAA AAA differ (ii) of sex specific. Methods results Aortic examination using computed tomography angiography was performed 11 294 individuals (56% women), a mean age 62 (range 40–95) years participating Copenhagen General Population Study. TAAs...
Background: Thymidine analogs and didanosine (ddI) have been associated with redistribution of body fat from subcutaneous adipose tissue (SAT) to visceral (VAT), which, in turn, is a risk factor for cardiovascular disease. We explored differences distribution between people living HIV (PLWH) prior exposure thymidine and/or ddI, without exposure, uninfected controls the association disease factors. Methods: In all, 761 PLWH Copenhagen Comorbidity Infection study, 2283 age sex-matched General...
Accurate assessment of aortic dimensions can be achieved using contrast-enhanced computed tomography. The aim this study was to define normal values and determinants throughout multiple key anatomical landmarks the aorta in healthy individuals from Copenhagen General Population Study.The group consisted 902 subjects selected 3000 adults undergoing cardiovascular thoracic abdominal tomography-angiography (CTA), where systematic measurements were performed retrospectively. Individuals included...
We tested the hypotheses (i) that elevated lipoprotein(a) is causally associated with both mitral and aortic valve calcification disease, (ii) mediates effect of on stenosis.From Copenhagen General Population study, we included 12,006 individuals who underwent cardiac computed tomography to measure 85,884 examine risk heart disease. Participants had information plasma genetic instruments investigate potential causality.At age 70-79 years, 29% 54% calcification, respectively. For 10-fold...
To assess the comparative effectiveness of computed tomography and invasive coronary angiography in women men with stable chest pain suspected to be caused by artery disease. Prospective, multicentre, randomised pragmatic trial. Hospitals at 26 sites 16 European countries. 2002 (56.2%) 1559 (43.8%) (total 3561 patients) disease referred for on basis a pre-test probability obstructive 10-60%. Both were 1:1 (with stratification gender centre) strategy either or as initial diagnostic test (1019...
Abstract Background & Aims Fatty liver disease has been associated with higher all‐cause as well liver‐related, ischemic heart (IHD)‐related and extrahepatic cancer‐related mortality in observational epidemiological studies. We tested the hypothesis that fatty is a causal risk factor for mortality. Methods genotyped seven genetic variants known to be (in PNPLA3 , TM6SF2 HSD17B13 MTARC1 MBOAT7 GCKR GPAM ) 110 913 individuals from Danish general population. Hepatic steatosis was measured...
The only treatment available for aortic valve stenosis is replacement, which makes it important to identify modifiable risk factors. We tested the hypotheses that diabetes and elevated plasma glucose are associated with mitral calcification stenosis, these associations explained partly by triglycerides, hypertension, body mass index. In Copenhagen General Population Study 110,291 individuals, we evaluated of regurgitation from health registers, in a subset 12,006 cardiac CT scanned...
Prominent left ventricular trabeculations is a phenotypic trait observed in cardiovascular diseases. In the general population, extent of highly variable, yet it unknown whether increased trabeculation associated with adverse outcome.Left trabeculated mass (g/m2) was measured contrast-enhanced cardiac computed tomography 10 097 individuals from Copenhagen General Population Study. The primary endpoint composite major events and defined as death, heart failure, myocardial infarction, or...
Abstract Aims Little is known about the prevalence of aortic aneurysms among people living with HIV (PLWH). We investigated whether status independently associated having aneurysms. Furthermore, we determined risk factors in PLWH. Methods and results PLWH aged ≥40 years (n = 594) were recruited from Copenhagen Comorbidity Infection study matched for age sex uninfected controls 1188) General Population Study. Aortic dimensions assessed using contrast enhanced computed tomography. defined...
Abstract Aims Quantitative computed tomography (QCT) allows assessment of morphological features coronary atherosclerosis. We aimed to test the hypothesis that clinical patient presentation is associated with distinct Methods and results A total 1652 participants, representing a spectrum risk profiles [787 asymptomatic individuals from general population, 468 patients acute chest pain without syndrome (ACS), 397 ACS], underwent multidetector tomography. Of these, 274 individuals, 254 ACS,...
Abstract Background People with human immunodeficiency virus (PWH) may be at risk of nonalcoholic fatty liver disease. We compared the prevalence moderate-to-severe hepatic steatosis (M-HS) in PWH (HIV)-uninfected controls and determined factors for M-HS PWH. Methods The Copenhagen Co-Morbidity HIV Infection study included 453 participants, General Population Study 765 participants. None had prior or current viral hepatitis excessive alcohol intake. Moderate-to-severe was assessed by...
Objectives Cardiovascular autonomic neuropathy (CAN) and abnormal circadian blood pressure (BP) rhythm are independent cardiovascular risk factors in patients with diabetes associations between CAN, non-dipping of nocturnal BP coronary artery disease have been demonstrated. We aimed to test if bedtime dosing (BD) versus morning (MD) the ACE inhibitor enalapril would affect 24-hour profile type 1 (T1D), CAN non-dipping. Setting Secondary healthcare unit Copenhagen, Denmark. Participants 24...
The effectiveness and safety of computed tomography (CT) invasive coronary angiography (ICA) in different age groups is unknown.
BACKGROUND: As a hypertensive disorder of pregnancy, preeclampsia is associated with increased cardiovascular morbidity and mortality later in life. Since early signs myocardial affection could indicate higher risk future disease manifestations, we investigated whether women prior have prevalence left ventricular hypertrophy compared from the general population to what extent chronic hypertension affects any potential difference. METHODS: In cohort study, aged 40 55 years were age-...
Abnormal ECGs are associated with increased risk of arrhythmias and sudden cardiac death. We aimed to investigate the prevalence factors prolonged QTc major ECG abnormalities, in persons living HIV (PLWH) uninfected controls.PLWH aged at least 40 years were recruited from Copenhagen comorbidity infection (COCOMO) study matched on sex age controls General Population Study.ECGs categorized according Minnesota Code Manual Findings definition abnormalities. A QT interval corrected for heart rate...
Patients with the hematological cancers Philadelphia-negative Myeloproliferative Neoplasms (MPNs) have an increased risk of cardiovascular disease. However, whether MPNs burden cardiac calcification has not been thoroughly investigated. Our aim is to investigate patients that could help explain their disease.We recruited 161 (mean age 65 years, 52% men) MPN diagnosis between 2016 and 2018. Coronary artery calcium score (CACS) aortic valve (AVC) were measured by computer tomography, detailed...
Background: Low bone mineral density (BMD) has been described in people living with HIV (PLWH). We examined the prevalence of low BMD measured by quantitative computed tomography (QCT), a method that allows 3-dimensional volumetric measures at thoracic spine, well-treated PLWH and uninfected controls assessed risk factors for reduced BMD. Methods: Cross-sectional study including 718 from Copenhagen Co-Morbidity infection (COCOMO) matched on age sex General Population Study (CGPS). Trabecular...
Background The optimal timing of invasive examination and treatment high-risk patients with non-ST-segment-elevation acute coronary syndrome has not been established. We investigated the efficacy early angiography compared standard-care on risk all-cause mortality according to GRACE (Global Registry Acute Coronary Events) score in a predefined subgroup analysis VERDICT (Very Early Versus Deferred Invasive Evaluation Using Computerized Tomography) trial. Methods Results Patients clinical...
Using four-dimensional (4D) cardiac computed tomography (CCT) scans at rest and immediately after exercise, we examined the right heart chamber sizes systolic function its association with exercise capacity in left ventricular assist device (LVAD) recipients. Fifteen patients HeartMate (HM) II or 3 underwent echocardiography maximal cardiopulmonary test. Subsequently, contrast-enhanced CCT were performed two minutes of supine 25 Watt ergometer bike exercise. Patients (60 ± 12 years age) 377...