A5011275184- High Altitude and Hypoxia
- Cancer, Hypoxia, and Metabolism
- Venous Thromboembolism Diagnosis and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroscience of respiration and sleep
- Eicosanoids and Hypertension Pharmacology
- Inflammasome and immune disorders
- RNA modifications and cancer
- MicroRNA in disease regulation
- Health and Medical Research Impacts
- Vitamin D Research Studies
- Cancer-related molecular mechanisms research
- Vitamin C and Antioxidants Research
- Mitochondrial Function and Pathology
- Biomarkers in Disease Mechanisms
- COVID-19 Clinical Research Studies
- Travel-related health issues
- Apelin-related biomedical research
- Infectious Encephalopathies and Encephalitis
- Heart Rate Variability and Autonomic Control
- PARP inhibition in cancer therapy
- Biochemical and Structural Characterization
- Endoplasmic Reticulum Stress and Disease
- Birth, Development, and Health
- Cardiovascular Health and Risk Factors
Institute of Genomics and Integrative Biology
2011-2025
University of Rajasthan
2024
Academy of Scientific and Innovative Research
2021-2024
All India Institute of Medical Sciences
2023
Creative Commons
2023
Jamia Millia Islamia
2019-2023
Jawaharlal Nehru University
2023
University of Delhi
2022
Council of Scientific and Industrial Research
2020-2021
Department of Biotechnology
2019-2021
Hypoxia is a major cause of pulmonary hypertension (PH) worldwide, and it likely that interstitial macrophages contribute to this vascular pathology. We observed in hypoxia-exposed mice an increase resident macrophages, which expanded through proliferation expressed the monocyte recruitment ligand CCL2. also CCR2+ recruitment, express protein thrombospondin-1 functionally activates TGF-beta disease. Blockade with either CCL2 neutralizing antibody treatment or CCR2 deficiency bone marrow...
EGLN1 [encoding HIF (hypoxia-inducible factor)-prolyl hydroxylase 2] plays a pivotal role in the pathway and has emerged as one of most intriguing genes with respect to physiology at HA (high altitude). EGLN1, being an actual oxygen sensor, appears have potential functional adaptation hypobaric hypoxic environment. In present study, we screened 30 polymorphisms evaluated its gene expression performed association analyses. addition, allelic variants altering TF (transcription factor)-binding...
Significance Exposure to a high-altitude (HA) hypobaric hypoxia environment produces physiological changes. Among these, the changes in apelin signaling system are significant because this regulates vascular and oxygen homeostasis. This study demonstrates that HA stimulates distinguish genetic variants methylation profile of CpG islands may impair or improve pulmonary function, thereby resulting edema (HAPE) patients adaptation healthy controls. Of several system, rs3761581 G rs2235312 T ,...
The interactions among various biomarkers remained unexplored under the stressful environment of high-altitude. Present study evaluated to susceptibility for high altitude pulmonary edema (HAPE) in HAPE-patients (HAPE-p) and adaptation highland natives (HLs); both comparison HAPE-free sojourners (HAPE-f). All subjects were recruited at 3500 m. We measured clinical parameters, biochemical levels plasma gene expression using RNA from blood; analyzed correlations between especially arterial...
HAPE (high-altitude pulmonary oedema) is characterized by hypertension, vasoconstriction and an imbalance in oxygen-sensing redox switches. Excess ROS (reactive oxygen species) contribute to endothelial damage under hypobaric hypoxia, hence the oxidative-stress-related genes CYBA (cytochrome b−245 α polypeptide) GSTP1 (glutathione transferase Pi 1) are potential candidate for HAPE. In present study, we investigated polymorphisms −930A/G H72Y (C/T) of I105V (A/G) A114V GSTP1, individually...
This study investigates the contribution of genetic interactions between β-2 adrenergic receptor (ADRB2) and nitric oxide synthase (NOS3) genes to complex etiology hypertension. Using single nucleotide polymorphism (SNP) markers, we studied potential ADRB2 NOS3 variants their correlation with clinical, biochemical, expression levels in 546 individuals hypertension 884 age-, sex-, ethnicity-matched unrelated control subjects. Generalized multifactor dimensionality reduction (GMDR) analysis...
The utility of cell-free (cf) DNA has extended as a surrogate or clinical biomarker for various diseases. However, more profound and expanded understanding the diverse cfDNA population its correlation with physiological phenotypes environmental factors is imperative using full potential. high-altitude (HA; altitude > 2,500 m above sea level) environment characterized by hypobaric hypoxia offers an observational case-control design to study differential profile in patients pulmonary edema...
Abstract Severe novel corona virus disease 2019 (COVID-19) infection is associated with a considerable activation of coagulation pathways, endothelial damage, and subsequent thrombotic microvascular injuries. These consistent observations may have serious implications for the treatment management this highly pathogenic disease. As consequence, anticoagulant therapeutic strategies, such as low molecular weight heparin, shown some encouraging results. Cytokine burst leading to sepsis which one...
Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and may result in an overactive coagulative system, thereby resulting serious cardiovascular consequences critically affected patients. The tract a primary target for COVID-19 infection, which manifested as lung injury most form of viral leading to failure. A proportion infected patients progress systemic including dysfunction multiple organs, distress (ARDS), coagulation...
Hypobaric hypoxia poses stress to sojourners traveling high-altitude. A cascade of physiological changes occurs cope with or adapt hypobaric hypoxia. However, an insufficient response the hypoxic condition resulting from imbalanced vascular homeostasis pathways results in high-altitude pulmonary edema (HAPE). The present study aims identify implication miRNAs associating HAPE and adaptation. We analyzed expression 1,113 HAPE-patients (HAPE-p), HAPE-free controls (HAPE-f), highland natives...
High-altitude (HA, >2500 m) hypoxic exposure evokes several physiological processes that may be abetted by differential genetic distribution in sojourners, who are susceptible to various HA disorders, such as high-altitude pulmonary edema (HAPE). The variants hypoxia-sensing genes influence the transcriptional output; however functional role has not been investigated HAPE. This study explored two genes, prolyl hydroxylase domain protein 2 (EGLN1) and factor inhibiting HIF-1α (HIF1AN)...
The Omicron sub-lineages are known to have higher infectivity, immune escape and lower virulence. During December 2022 - January 2023 March April 2023, India witnessed increased SARS-CoV-2 infections, mostly due newer sub-lineages. With this unprecedented rise in cases, we assessed the neutralization potential of individuals vaccinated with ChAdOx1 nCoV (Covishield) BBV152 (Covaxin) against emerging
Abstract Background High-altitude (HA, 2500 m) hypoxic exposure evokes a multitude of physiological processes. The hypoxia-sensing genes though influence transcriptional output in disease susceptibility; the exact regulatory mechanisms remain undetermined high-altitude pulmonary edema (HAPE). Here, we investigated differential DNA methylation distribution two encoding oxygen-sensing HIF-prolyl hydroxylases, prolyl hydroxylase domain protein 2 (PHD2) and factor inhibiting HIF-1α consequent...
Thrombospondin-1 (THBS1) levels elevate under hypoxia and have relevance in several cardiovascular disorders. The association of THBS1 with endothelial dysfunction implies its important role hypertension. To establish the hypothesis, we screened patients hypertension their respective controls from two different environmental regions. Cohort 1 was composed Ladakhis, residing at 3500 m above sea level (ASL), whereas 2 north-Indians ~200 ASL. Clinical parameters circulating were correlated...
Abstract Acute high-altitude (HA) exposure can induce several pathologies. Dexamethasone (DEX) be taken prophylactically to prevent HA disease, but the mechanism by which it acts in this setting is unclear. We studied transcriptome of peripheral blood mononuclear cells (PBMCs) from 16 subjects at low altitude (LA, 225 m) and then 3 days after acute travel (3500 during India-Leh-Dexamethasone-Expedition-2020 (INDEX2020). Half participants received oral DEX prophylaxis 4 mg twice daily an...