A5064659899- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- HIV-related health complications and treatments
- Atrial Fibrillation Management and Outcomes
- Diabetes Treatment and Management
- Ion channel regulation and function
- Advanced X-ray and CT Imaging
- Coronary Interventions and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Pain Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Cardiovascular Disease and Adiposity
- Diabetes Management and Research
- Aortic aneurysm repair treatments
- Cardiac Arrhythmias and Treatments
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Liver Disease Diagnosis and Treatment
- Cardiovascular Issues in Pregnancy
- Aortic Disease and Treatment Approaches
- Pregnancy and preeclampsia studies
- Cardiac electrophysiology and arrhythmias
- Organic Electronics and Photovoltaics
- Atherosclerosis and Cardiovascular Diseases
Copenhagen University Hospital
2017-2025
Rigshospitalet
2016-2025
University of Copenhagen
2015-2024
Mount Sinai Health System
2020
University of Freiburg
2006-2019
BASF (Germany)
2012
Robert Bosch (Germany)
2011
Medical University of Graz
2005-2008
Medical College of Wisconsin
2005-2008
Innsbruck Medical University
2005
Four-dimensional volume-rendered computed tomography (4DCT) has demonstrated instances of hypo-attenuating leaflet thickening (HALT) with or without hypo-attenuation affecting motion (HAM) after transcatheter and surgical aortic valve implantation (TAVI, SAVR). The temporal pattern evolution these phenomena is uncertain.The SAVORY registry enrolled patients treated by TAVI (n = 75) SAVR 30) two 4DCT scans fully interpretable for HALT HAM as well unchanged anti-thrombotic medication between...
Coronary atherosclerosis may develop at an early age and remain latent for many years.To define characteristics of subclinical coronary associated with the development myocardial infarction.Prospective observational cohort study.Copenhagen General Population Study, Denmark.9533 asymptomatic persons aged 40 years or older without known ischemic heart disease.Subclinical was assessed computed tomography angiography conducted blinded to treatment outcomes. characterized according luminal...
Kills germs on contact! Environmentally friendly aqueous dispersions of polymer nanobeads with a surface-grafted antimicrobial emulsifier were prepared. Coatings prepared from these (see picture) kill microbes contact, without releasing biocide.
Normal values of left ventricular mass (LVM) and cardiac chamber sizes are prerequisites for the diagnosis individuals with heart disease. LVM may be recorded during computed tomography angiography (CCTA), thus modality specific normal needed. We studied 569 healthy subjects undergoing 320-detector CCTA as a part Copenhagen General Population Study. well atrial volumes was assessed semi-automated software stratified by gender age decades indexed body surface area (BSA). Mean 55 (range:...
Abstract Aims The prevalence and difference in risk factors for having thoracic aortic aneurysm (TAA) abdominal (AAA) men compared with women the general population is not well described. This study aimed to test hypotheses that (i) cardiovascular TAA AAA differ (ii) of sex specific. Methods results Aortic examination using computed tomography angiography was performed 11 294 individuals (56% women), a mean age 62 (range 40–95) years participating Copenhagen General Population Study. TAAs...
Abstract To investigate if progression of coronary artery calcification (CAC) in patients with systemic lupus erythematosus (SLE) is associated renal and traditional cardiovascular risk factors as well incidence myocardial infarctions. CAC was evaluated by cardiac computed tomography (CT) at baseline after 5 years. Multivariable Poisson regression applied to associations between values for factors, CAC, SLE disease duration, nephritis, function. Regarding function, three groups were defined...
Nerve injury that produces behavioral changes of allodynia and hyperalgesia in animals is associated with electrophysiologic dorsal root ganglion (DRG) cells. The introduction drugs into the DRG or peripheral nerve alter calcium, sodium, potassium channel activity may be therapeutic benefit after injury. For this reason, authors sought to determine whether do not ordinarily cross blood-nerve barrier will enter intravenous regional injection alters drug access DRGs nerves.Both intact spinal...
The electronic structure at organic/organic interfaces plays a key role, among others, in defining the quantum efficiency of organics-based photovoltaic cells. Here, we perform quantum-chemical and microelectrostatic calculations on molecular aggregates various sizes shapes to characterize interfacial dipole moment pentacene/C60 heterojunctions. results show that mostly originates polarization effects due asymmetry multipolar expansion density distribution between interacting molecules,...
Abstract In this study the charge dissociation at donor/acceptor heterointerface of thermally evaporated planar heterojunction merocyanine/C 60 organic solar cells is investigated. Deposition donor material on a heated substrate as well post‐annealing complete devices temperatures above glass transition temperature results in twofold increase fill factor. An analytical model employing an electric‐field‐dependent exciton mechanism reveals that geminate recombination limiting performance...
This study aimed to assess the potential relationship between subclinical leaflet thickening and stent frame geometry in patients who underwent aortic valve replacement with a self-expanding transcatheter heart (THV).Seventy-five THV were studied 4D-computed tomography analysed for thickening. There was no difference size, overall expansion, eccentricity or implantation depth those without Moderate-to-severe regional underexpansion (≤90°) more frequently occurred at non-coronary right...
Abstract Background The impact of gut microbiota and its metabolites on coronary artery disease (CAD) in people with human immunodeficiency virus (PWH) is unknown. Emerging evidence suggests that imidazole propionate (ImP), a microbial metabolite, linked cardiometabolic diseases. Methods Fecal samples from participants the Copenhagen Comorbidity HIV infection (COCOMO) study were processed for 16S rRNA sequencing ImP measured liquid chromatography-tandem mass spectrometry. CAD severity was...
Background The electrocardiographic interatrial block ( IAB ) has been associated with atrial fibrillation AF ). We aimed to test whether can improve risk prediction of for the individual person. Methods and Results Digital ECGs 152 759 primary care patients aged 50 90 years were collected from 2001 2011. identified individuals P‐wave ≥120 ms presence none, 1, 2, or 3 biphasic P‐waves in inferior leads. Data on comorbidity, medication, outcomes obtained nationwide registries. observed a...
In order to determine the molecular origin of difference in electron and hole mobilities amorphous thin films Alq(3) (meridional (tris(8-hydroxyquinoline) aluminium)) we performed multiscale simulations covering quantum mechanics, mechanics lattice models. The study includes realistic disordered morphologies, polarized site energies describe diagonal disorder, chemically calculated transfer integrals for off-diagonal inner sphere reorganization an approximative scheme outer energies....
Background: Thymidine analogs and didanosine (ddI) have been associated with redistribution of body fat from subcutaneous adipose tissue (SAT) to visceral (VAT), which, in turn, is a risk factor for cardiovascular disease. We explored differences distribution between people living HIV (PLWH) prior exposure thymidine and/or ddI, without exposure, uninfected controls the association disease factors. Methods: In all, 761 PLWH Copenhagen Comorbidity Infection study, 2283 age sex-matched General...
Accurate assessment of aortic dimensions can be achieved using contrast-enhanced computed tomography. The aim this study was to define normal values and determinants throughout multiple key anatomical landmarks the aorta in healthy individuals from Copenhagen General Population Study.The group consisted 902 subjects selected 3000 adults undergoing cardiovascular thoracic abdominal tomography-angiography (CTA), where systematic measurements were performed retrospectively. Individuals included...
We tested the hypotheses (i) that elevated lipoprotein(a) is causally associated with both mitral and aortic valve calcification disease, (ii) mediates effect of on stenosis.From Copenhagen General Population study, we included 12,006 individuals who underwent cardiac computed tomography to measure 85,884 examine risk heart disease. Participants had information plasma genetic instruments investigate potential causality.At age 70-79 years, 29% 54% calcification, respectively. For 10-fold...
Abstract Background & Aims Fatty liver disease has been associated with higher all‐cause as well liver‐related, ischemic heart (IHD)‐related and extrahepatic cancer‐related mortality in observational epidemiological studies. We tested the hypothesis that fatty is a causal risk factor for mortality. Methods genotyped seven genetic variants known to be (in PNPLA3 , TM6SF2 HSD17B13 MTARC1 MBOAT7 GCKR GPAM ) 110 913 individuals from Danish general population. Hepatic steatosis was measured...
People with HIV (PWH) have a high risk of coronary artery disease (CAD). Cytomegalovirus (CMV) co-infection is very common in PWH, but little known about its association CAD. We aimed to investigate if CMV IgG serostatus and concentrations are associated CAD PWH. From the Copenhagen Comorbidity Infection (COCOMO) Study we included PWH CT angiography (CCTA) quantitative concentration measurements. measured stenosis grades plaque volumes vessels. Using multivariable regressions adjusted for...