A5103092004- Cardiovascular Issues in Pregnancy
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Cardiac Structural Anomalies and Repair
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Viral Infections and Vectors
- Blood groups and transfusion
- Gestational Diabetes Research and Management
- Hemoglobinopathies and Related Disorders
- Tracheal and airway disorders
- Takotsubo Cardiomyopathy and Associated Phenomena
- Chronic Myeloid Leukemia Treatments
- Polyomavirus and related diseases
- Folate and B Vitamins Research
- Aortic Disease and Treatment Approaches
- Neonatal Health and Biochemistry
- Congenital heart defects research
- BRCA gene mutations in cancer
- Hemoglobin structure and function
- Spinal Dysraphism and Malformations
- Fetal and Pediatric Neurological Disorders
- Organ and Tissue Transplantation Research
- Viral-associated cancers and disorders
- Cystic Fibrosis Research Advances
Rigshospitalet
1955-2024
University of Copenhagen
1973-2024
Copenhagen University Hospital
2017-2024
Odense University Hospital
1975-1984
Danish Energy Agency
1958-1977
Kennedy Center
1973
Institute of Forensic Science
1973
Kolding Hospital
1973
London School of Hygiene & Tropical Medicine
1970
Institute of Genetics
1963-1970
A family in which a translocation t(11; 21) (q23 ;q22) was segregating through three generations studied clinically and cytogenetically. Individuals mono somic for the distal part of long arm chromosome No. 11 showed severe malformations retardation. Apatient trisomic this mentally retarded but less severely affected. Marker gene studies could exclude location several blood group loci at 11, did not give any positive evidence linkage to part.
It seems to be generally accepted that genetic factors take a place among the causes of coronary heart disease. Careful and extensive family studies, others by workers in Carter's group, have shown risk close relatives patients with disease is significantly increased. This may, however, an effect common social background families. Systematic twin investigations been needed, which could distinguish between effects environment genes, allow estimate relative importance environmental factors....
Background Long-term clinical studies of peripartum cardiomyopathy ( PPCM ) are few. We aimed to measure the long-term effect on cardiac function in comparison with effects severe preeclampsia and uncomplicated pregnancy. Methods Results A nationwide Danish cohort women diagnosed from 2005 2014 group) were invited participate a follow-up study including maximal cardiopulmonary exercise testing magnetic resonance imaging. Matched previous (preeclampsia pregnancies (uncomplicated served as...
Abstract The mothers of a consecutive series 125 same sexed pairs twins aged 6 months to 1/2 years completed mailed questionnaire concerning the physical similarity twin partners. Zygosity diagnoses were first determined blindly on basis answers given by mothers, who did not know result blood group test when fullfilling questionnaire. Next, results compared with zygosity determination based examination erythrocyteserum- and enzyme-groups. It turned out that few simple questions distinguished...
ABSTRACT. The entire population of cystic fibrosis (CF) patients in Denmark diagnosed the period January 1, 1945, to June 30,1985, comprised 514 persons whom 62 were at autopsy. Of remaining 452 patients, 372 probands and 80 secondary cases. effect a centralized treatment on prognosis was evaluated using Cox's regression model. Furthermore an incidence analysis performed including autopsies. Centrab'zed had significantly beneficial ( p =0.02), death intensity (hazard rate) being decreased by...
BACKGROUND: As a hypertensive disorder of pregnancy, preeclampsia is associated with increased cardiovascular morbidity and mortality later in life. Since early signs myocardial affection could indicate higher risk future disease manifestations, we investigated whether women prior have prevalence left ventricular hypertrophy compared from the general population to what extent chronic hypertension affects any potential difference. METHODS: In cohort study, aged 40 55 years were age-...
Anticonvulsants have been suspected of teratogenicity, with facial clefts being the malformation most frequently associated maternal anticonvulsant therapy. Paternal epilepsy has also suggested as a factor in genesis birth defects, including clefts. An association between per se and would be reflected higher cleft prevalence among epileptics, consequently result an increase such malformations their children. The was determined unselected group 3,203 epileptic probands: personal data were...
In a study of congenital heart defects (CHD) in 2,461 live-born children an unselected group 979 male and 1,093 female epileptics, 18 with CHD were recorded; eight had epileptic fathers 10 mothers. The prevalence does not differ significantly from that the background population. Many different types recorded no single defect being predominant. Likewise, association specific type anticonvulsant treatment was noted. fact among epileptics population similar supports view antiepileptic is major...
Between 1965 and 1973, 30 malignant tumours were found in patients transplanted Scandinavia. Of these tumours, 24 the 1,254 Scandinavia as part of Scandia Tranplant Programme between 1969 1972. Using information recorded programme, 418 Danish who received their first only transplant 1972 selected followed until 31/12 1973. Twelve occurred patients. A comparison with expected age, sex time-specific incidence rates from Cancer Register was made observed tumour to be significantly (P less than...
To describe the subsequent reproductive outcome for a Danish nationwide cohort of women with peripartum cardiomyopathy (PPCM).Nationwide historic study.Secondary and tertiary centres across Denmark.Women PPCM.Sixty-one PPCM during 2005-2014 were identified in nationwide, registry-based study diagnosis was validated through audit patient records. A new search this from 2005-2016 conducted National Birth Registry Patient Registry. Detailed clinical data obtained records.Sterilisations outcomes...
Abstract Background Preeclampsia is associated with increased risk of cardiovascular disease later in life, but studies suggest that women previous preeclampsia are not aware this. Little known about how these perceive the condition and long-term risks. We examined experiences perceptions (CVD) life among Danish their attitudes towards CVD screening. Methods Ten individual semi-structured interviews were conducted preeclampsia. Data analysed using thematic analysis. Results identified six...
The Danish Twin Register, which comprises all twins born in Denmark between 1870 and 1920, has been used for studies of selected problems the field epidemiology public health. This report gives a survey preliminary results an investigation this type, intends to amplify present knowledge about possible harmful effects smoking on health, by taking advantage twin material makes it keep genetic factors under control. A series 762 MZ same-sexed DZ pairs, had their habits mapped 1959, followed...
Younger women with previous preeclampsia have an increased risk of coronary atherosclerosis. It is unknown if this associated the time onset preeclampsia.
Sampling methods hitherto used in epidemiological surveys have generally faced two major sorts of potential bias: (I) a latent period between listing and testing listed individuals which can cause misrepresentation the population under study, compared with basis; (2) migration death during study period. may result discrepancy selected for part examined. A Central Population Register, found all Scandinavian countries, permits an evaluation size these problems bias makes it possible to use...