A5076276231- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- Viral Infections and Immunology Research
- Congenital Heart Disease Studies
- Cardiovascular Disease and Adiposity
- Heart Rate Variability and Autonomic Control
- Advanced MRI Techniques and Applications
- Vagus Nerve Stimulation Research
- Cardiovascular Health and Disease Prevention
- Atrial Fibrillation Management and Outcomes
- Pulmonary Hypertension Research and Treatments
- Cardiomyopathy and Myosin Studies
- Acute Myocardial Infarction Research
- Dialysis and Renal Disease Management
- Adolescent and Pediatric Healthcare
- Aortic Disease and Treatment Approaches
- Cardiac Structural Anomalies and Repair
- Acute Lymphoblastic Leukemia research
- Monoclonal and Polyclonal Antibodies Research
- Liver Disease Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Inflammatory Myopathies and Dermatomyositis
Copenhagen University Hospital
2018-2025
Rigshospitalet
2018-2025
University of Copenhagen
2020-2022
University College London
2021
Abstract To investigate if progression of coronary artery calcification (CAC) in patients with systemic lupus erythematosus (SLE) is associated renal and traditional cardiovascular risk factors as well incidence myocardial infarctions. CAC was evaluated by cardiac computed tomography (CT) at baseline after 5 years. Multivariable Poisson regression applied to associations between values for factors, CAC, SLE disease duration, nephritis, function. Regarding function, three groups were defined...
Cardiovascular diseases manifest differently in males and females, potentially influenced by inherent sex- age-related differences myocardial tissue composition. Such are not well-established the literature. With this study using cardiac magnetic resonance (CMR) native T1 mapping, we aim to determine effect of sex age on composition healthy individuals. CMR mapping was performed 276 individuals (55% male, 8---84 years) a 1.5 Tesla scanner MOLLI 5(3)3 acquisition scheme. Additionally, 30...
Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that carries increased risk of cardiovascular disease; however, the underlying pathophysiological mechanisms remain poorly understood. We aimed to investigate prevalence and degree myocardial fibrosis in SLE patients associated characteristics. Forty-nine (89% female, mean age 52 ± 13 years, median duration 19 (11–25) years) 79 sex-and age-matched healthy controls were included. CMR with T1 mapping was performed on...
Introduction More than 90% of patients diagnosed with childhood acute lymphoblastic leukaemia (ALL) today will survive. However, half the survivors are expected to experience therapy-related chronic or late occurring adverse effects, reducing quality life. Insight into underlying risk trajectories is warranted. The aim this study establish a Nordic, national ALL survivor cohort, be investigated for total somatic and psychosocial treatment-related burden as well associated factors, allowing...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. SLE treated with immunosuppressants suboptimal efficacy and high risk of serious side effects. Patients have increased mortality, organ damage debilitating treatment-resistant fatigue. Autonomic nervous system dysfunction (AD) present in approximately half the patients may promote autoimmunity by weakening vagally mediated anti-inflammatory reflex. Recent studies suggest that transcutaneous vagus nerve stimulation (tVNS) has...
To compare two-dimensional (2D) and three-dimensional (3D) methods to estimate left ventricular ejection fraction (LVEF) with respect feasibility, time consumption, retest reproducibility.A total of 100 patients planned undergo coronary artery bypass grafting and/or aortic valve replacement were included consecutively. 2D 3D echocardiography was performed on all patients. Acquisition analysis as well intra- inter-examiner variability assessed in 50 consecutive 3 repeated echocardiographic...
Left ventricular (LV) mass (LVM) is a predictor of cardiovascular morbidity and mortality commonly calculated using 1-dimensional (1D) echocardiographic methods. These methods are vulnerable to small measurement errors LVM may wrongly change according changes in LV volume (LVV). Less used 2-dimensional (2D) can accommodate the LVV be better alternative among patients receiving hemodialysis (HD) with large fluid fluctuations.
Increased left ventricular mass (LVM) is a strong independent predictor for adverse cardiovascular events, but conventional echocardiographic methods are limited by poor reproducibility and accuracy. We developed novel method based on adding the mean wall thickness from parasternal short axis view, to end-diastolic volume acquired using biplane model of discs. The participants (n = 85) had various geometries were assessed echocardiography followed immediately cardiac magnetic resonance, as...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with increased risk of cardiac dysfunction. The pathophysiological mechanisms are poorly understood, and prognostic markers warranted. We aimed to identify SLE-characteristics associated measures size function during five-year follow-up. included 108 patients SLE: 90% females, mean age 46 ± 13 years, median duration 14 (range 7–21) years. performed blood sampling for potential biomarkers as well standard echocardiography at...
<h3>Background:</h3> Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease that carries an increased risk of comorbidity, organ damage, low quality life, work incapacity, and mortality. The cornerstone current care immunosuppression aimed to reduce activity, which, however, has limited effect in relieving patients from constitutive symptoms like fatigue. To the use traditional immunosuppressing treatment, alternative means attenuating inflammation treatment-resistant...
Abstract Changes in hydration status may affect myocardial native T1 and T2 values influence the clinical interpretation. We aimed to assess impact of acute preload augmentation on T2. Cardiovascular magnetic resonance (CMR) mapping were performed twice same day 20 healthy participants before after an by a 2-liter intravenous infusion isotonic sodium chloride (0.9%). Test-retest reproducibility was evaluated 30 with two consecutive CMR examinations day. Sixteen included both substudies. In...
Abstract Background Global longitudinal strain (GLS) is a predictor of outcome after cardiac surgery. If integrated into clinical decision‐making and timing surgery, it important to evaluate the feasibility, reproducibility, variation GLS in this selection patients, where poor image quality nontraceable segments are frequent. Methods results Two‐dimensional analysis was performed on 250 patients planned undergo open‐heart Intra‐ inter‐examiner retest variability assessed 50 consecutive...
(1) Background: To investigate how food intake and preload augmentation affect the cardiac output (CO) volumes of left ventricle (LV) right (RV) assessed using magnetic resonance (CMR) trans-thoracic echocardiography (TTE). (2) Methods: Eighty-two subjects with (n = 40) without 42) disease were both CMR TTE immediately before after a fast infusion 2 L isotonic saline. Half population had meal during saline (food/fluid), other half kept fasting (fasting/fluid). We analyzed end-diastolic (EDV)...
Abstract Purpose Increased left ventricular mass (LVM) is a strong independent predictor for adverse cardiovascular events, but conventional echocardiographic methods used to assess and monitor individuals are limited by poor reproducibility accuracy. We aimed develop an method LVM-quantification that simple, reproducible accurate. Methods The novel adds the mean wall thickness end-diastolic volume acquired using biplane model of discs. from parasternal short axis view. Cardiac assessment...
Aims To evaluate the feasibility, time consumption, intra- and inter-observer re-test reproducibility of echocardiographic indexes classification algorithms diastolic function. Methods A total 356 patients were examined prior to coronary art
Background Systemic lupus erythematosus (SLE) is an autoimmune disease with increased risk of cardiovascular complications such as coronary artery disease, myocarditis, pericarditis, and valvular dysfunction (1─3). The pathophysiological mechanisms are poorly understood markers to identify high patients warranted. Objectives We aimed SLE-characteristics that associated progressive cardiac dysfunction. Methods A total 108 SLE (90 % female, mean age 46±13 years, median duration 14 (7-21)...