Amy Diallo
A5028975532- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- interferon and immune responses
- Protein Degradation and Inhibitors
- Computational Drug Discovery Methods
- Chromatin Remodeling and Cancer
- RNA and protein synthesis mechanisms
- Nematode management and characterization studies
- Global Health and Surgery
- COVID-19 Clinical Research Studies
- Bioinformatics and Genomic Networks
- Competency Development and Evaluation
- SARS-CoV-2 detection and testing
- Counseling Practices and Supervision
- Immunodeficiency and Autoimmune Disorders
- Biomedical and Engineering Education
- Poxvirus research and outbreaks
- Mitochondrial Function and Pathology
- Genetics, Bioinformatics, and Biomedical Research
- Protist diversity and phylogeny
- Bacteriophages and microbial interactions
- Click Chemistry and Applications
- Machine Learning in Bioinformatics
- Synthesis and biological activity
University of California, San Francisco
2020-2025
Quantitative BioSciences
2021-2022
Molecular Biology Consortium
2020-2021
University of San Francisco
2021
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a grave threat to public health and the global economy. SARS-CoV-2 closely related more lethal but less transmissible coronaviruses SARS-CoV-1 Middle East (MERS-CoV). Here, we have carried out comparative viral-human protein-protein interaction viral protein localization analyses for all three viruses. Subsequent functional genetic screening identified host factors that functionally impinge on...
Abstract The SARS-CoV-2 protein Nsp2 has been implicated in a wide range of viral processes, but its exact functions, and the structural basis those remain unknown. Here, we report an atomic model for full-length obtained by combining cryo-electron microscopy with deep learning-based structure prediction from AlphaFold2. resulting reveals highly-conserved zinc ion-binding site, suggesting role RNA binding. Mapping emerging mutations variants on shows potential host-Nsp2 interaction regions....
The main protease (MPro) of SARS-CoV-2 is crucial for viral replication and the target nirmatrelvir (the active ingredient Paxlovid) ensitrelvir. identification new agents with differentiated pharmacokinetic drug resistance profiles will increase therapeutic options COVID-19 patients bolster pandemic preparedness generally. Starting a lead-like dihydrouracil chemotype from large-library docking campaign, we improved MPro inhibition >1,000 fold by engaging additional subsites in site, most...
Inhibitors of bromodomain and extraterminal domain (BET) proteins are possible anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prophylactics as they downregulate angiotensin-converting enzyme (ACE2). Here we show that BET should not be inactivated therapeutically because critical antiviral factors at the post-entry level. Depletion BRD3 or BRD4 in cells overexpressing ACE2 exacerbates SARS-CoV-2 infection; same is observed when with endogenous expression treated inhibitors...
The SARS-CoV-2 protein Nsp2 has been implicated in a wide range of viral processes, but its exact functions, and the structural basis those remain unknown. Here, we report an atomic model for full-length obtained by combining cryo-electron microscopy with deep learning-based structure prediction from AlphaFold2. resulting reveals highly-conserved zinc ion-binding site, suggesting role RNA binding. Mapping emerging mutations variants on shows potential host-Nsp2 interaction regions. Using...
Inhibitors of Bromodomain and Extra-terminal domain (BET) proteins are possible anti-SARS-CoV-2 prophylactics as they downregulate angiotensin-converting enzyme 2 (ACE2). Here, we show that BET should not be inactivated therapeutically critical antiviral factors at the post-entry level. Knockouts BRD3 or BRD4 in cells overexpressing ACE2 exacerbate SARS-CoV-2 infection; same is observed when with endogenous expression treated inhibitors during infection, before. Viral replication mortality...
Science education and research have the potential to drive profound change in low- middle-income countries (LMICs) through encouraging innovation, attracting industry, creating job opportunities. However, LMICs, capacity is often limited, acquisition of funding access state-of-the-art technologies challenging. The Alliance for Global Health (the Alliance) was founded as a partnership between University California, Berkeley (USA) Makerere (Uganda), with goal strengthening University's...