A5051580976- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Immune Cell Function and Interaction
- Global Health and Surgery
- Genetics, Bioinformatics, and Biomedical Research
- Viral Infections and Outbreaks Research
- Pneumonia and Respiratory Infections
- vaccines and immunoinformatics approaches
- HIV Research and Treatment
- Immune cells in cancer
- Biotechnology and Related Fields
- Cytokine Signaling Pathways and Interactions
- Pressure Ulcer Prevention and Management
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Wound Healing and Treatments
- Global Public Health Policies and Epidemiology
- Diabetic Foot Ulcer Assessment and Management
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Biomedical and Engineering Education
- Computational Drug Discovery Methods
- Global Maternal and Child Health
University Hospitals of Cleveland
2023
Case Western Reserve University
2023
University School
2023
Makerere University
2017-2022
Mulago Hospital
2014
Pressure ulcers have been identified as a major burden of hospitalization worldwide, and nurses are at the forefront prevention. The purpose this study was to determine nurses' knowledge practices regarding risk factors, prevention, management pressure teaching hospital in Uganda. employed descriptive cross-sectional design. Fifty-six Ugandan registered practicing were sampled. A composite self-administered questionnaire an observation checklist utilized. had limited about critical...
Objectives Early diagnosis and timely treatment are key elements of a successful healthcare system. We assessed the role socioeconomic cultural norms in accelerating or decelerating uptake utilisation health technologies into policy practice. Setting Secondary tertiary level facilities (HCFs) three East African countries. Level HCF was selected based on WHO recommendation for implantation tuberculosis (TB) molecular diagnostics. Participants Using implementation TB diagnostics as model, we...
Direct recognition of
Abstract Mycobacterium tuberculosis cell-wall glycolipids such as mannosylated lipoarabinomannan (ManLAM) can inhibit murine CD4+ T cells by blocking TCR signaling. This results in suppression of IL-2 production, reduced cell proliferation, and induction anergy. study extended these findings to the interaction between primary human macrophages infected mycobacteria. Exposure ManLAM before activation resulted loss polyfunctionality, measured IL-2, IFN-γ, TNF-α expression, CD25 expression. was...
Background Early access to diagnosis is crucial for effective management of any disease including tuberculosis (TB). We investigated the barriers and opportunities maximise uptake utilisation molecular diagnostics in routine healthcare settings. Methods Using implementation WHO approved TB diagnostics, Xpert Mycobacterium /rifampicin (MTB/RIF) Line Probe Assay (LPA) as a benchmark, we evaluated how they could be unlocked diagnostics. Results Health officers representing 190...
Laboratory diagnosis of Tuberculosis (TB) is traditionally based on microscopy and or culture. Microscopy however, only sensitive to a specified degree bacillary load not present in HIV co-infected persons. Traditional cultures Mycobacterium tuberculosis (M. tb), the other hand, take weeks read—thereby delaying critical decision whether not, treat. Although nucleic acids amplification tests (NAATS) applied directly sputum can increase sensitivity for TB among those with co-infection as well...
Summary Endemic Burkitt lymphoma (eBL) is an aggressive childhood B‐cell associated with Plasmodium falciparum ( Pf ) malaria and Epstein–Barr virus (EBV) infections. Variation in the Human Leukocyte Antigen (HLA) system suspected to play a role, but assessments using less accurate serology‐based HLA typing techniques small studies yielded conflicting results. We studied 200 eBL cases 400 controls aged 0–15 years enrolled northern Uganda typed by high‐resolution sequencing methods. results...
Clinical and laboratory diagnosis of Active Tuberculosis (ATB) latent
Science education and research have the potential to drive profound change in low- middle-income countries (LMICs) through encouraging innovation, attracting industry, creating job opportunities. However, LMICs, capacity is often limited, acquisition of funding access state-of-the-art technologies challenging. The Alliance for Global Health (the Alliance) was founded as a partnership between University California, Berkeley (USA) Makerere (Uganda), with goal strengthening University's...
Direct recognition of Mycobacterium tuberculosis (Mtb) infected cells is required for protection by CD4+ T cells. While impaired cell Mtb-infected macrophages was demonstrated in mice, data are lacking humans. Using and monocyte-derived (MDMs) from individuals with latent Mtb infection (LTBI), we quantified the frequency memory activation response to autologous MDMs virulent Mtb. We observed robust Mtb-infection differentiated using GM-CSF, while those M-CSF were poorly recognized. However,...
Background Billions of dollars are spent on research globally every year, yet little is translated to public use through policy and/or commercialisation. For the few findings that make it policy, evidence in most LMICs shows they hardly see light implementation. Our EDCTP-funded TWENDE consortium used implementation tuberculosis (TB) molecular diagnostics as a model investigate barriers, and opportunities unlock them order maximise uptake health innovations into practice. Methods Mixed...
Abstract Background : Tuberculosis (TB), a treatable disease claims over million lives every year. Accurate rapid diagnosis is crucial for early treatment initiation and prevention of severe disease. Despite 10 years approval molecular diagnostics routine use, an estimated 3 TB cases go undetected per We investigated the barriers opportunities to maximise uptake utilization in healthcare settings. Methods deployed surveys, facility audits, focus group discussions, in-depth interviews,...