A5100378246- Reproductive System and Pregnancy
- Prenatal Screening and Diagnostics
- Ovarian function and disorders
- Genomic variations and chromosomal abnormalities
- Endometriosis Research and Treatment
- Sperm and Testicular Function
- Hypothalamic control of reproductive hormones
- Chromosomal and Genetic Variations
- Reproductive Physiology in Livestock
- Ginseng Biological Effects and Applications
- Estrogen and related hormone effects
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hepatitis B Virus Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Signaling Pathways in Disease
- Calcium signaling and nucleotide metabolism
- Cytokine Signaling Pathways and Interactions
- Vitamin C and Antioxidants Research
- Pregnancy and Medication Impact
- Inflammasome and immune disorders
- Medicinal Plants and Neuroprotection
- Sexual Differentiation and Disorders
- Congenital heart defects research
- Scientific and Engineering Research Topics
- Drug-Induced Hepatotoxicity and Protection
Nanjing University of Chinese Medicine
2018-2024
Women's Hospital, School of Medicine, Zhejiang University
2018-2022
China Pharmaceutical University
2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2019
Xiyuan Hospital
2019
Zhejiang University
2018
Shanghai First People's Hospital
2017
Xi'an Jiaotong University
2017
Wuhan University of Science and Technology
2016
Curcumin alleviates septic acute kidney injury (SAKI); however, the underlying mechanism remained unclear. To explore this, SAKI cell model and mice were conducted by using LPS cecal ligation puncture (CLP), respectively. Cell counting kit-8 (CCK-8) enzyme-linked immunosorbent assay (ELISA) assays indicated that reduced viability, but upregulated levels of tumor necrosis factor (TNF)-α interleukin (IL)-6, whereas pretreatment had no effect on TNF-α IL-6. Further showed partly attenuated...
Pulmonary fibrosis is common in a variety of inflammatory lung diseases, there currently no effective clinical drug treatment. It has been reported that the ethanol extract Eclipta prostrata L. can improve collagen deposition and pathology induced by bleomycin (BLM) mice. In present study, we studied whether wedelolactone (WEL), major coumarin ingredient E. prostrata, provided protection against BLM-induced pulmonary fibrosis. ICR or C57/BL6 strain mice were treated with BLM to establish...
The aim of this study was to explore the effect and mechanism action resveratrol (RSV) on cardiac function in diabetic cardiomyopathy (DCM). Hyperglycemia-induced apoptosis contributes pathogenic changes DCM. RSV treatment inhibited high glucose-induced neonatal rat ventricular myocytes. Additionally, glucose decreased cell viability, prevented serine-threonine kinase (Akt) FoxO3a phosphorylation, suppressed cytoplasmic translocation FoxO3a. However, these effects were reversed by 10 μM RSV....
Paroxysmal atrial fibrillation (AF) combined with obstructive sleep apnea hypopnea syndrome (OSAHS) is very common in clinical practice. Traditional Chinese medicine (TCM) rule of regulating the liver based on psycho-cardiology shows satisfactory effectiveness treatment paroxysmal AF OSAHS. However, its underlying pharmacological mechanism has not yet been elucidated. This study applied network pharmacology to identify 94 active components six TCM liver-regulating herbs and 182 corresponding...
Tanshinone IIA (TSIIA) is a major component of Salvia miltiorrhiza, Chinese herb that exhibits therapeutic effect on polycystic ovary syndrome (PCOS). The present study replicated PCOS via the neonatal treatment estradiol in mice. Estrous cycles, body and ovarian weight, serum levels testosterone were determined. Histological examination ovaries was performed. mRNA protein aromatase luteinizing hormone receptor follicle-stimulating (FSHR) granule cells assayed by reverse...
Recent advances in semiconductor sequencing platform (SSP) have provided new methods for preimplantation genetic diagnosis/screening (PGD/S). The present study aimed to evaluate the applicability and efficiency of SSP PGD/S. artificial positive single-cell-like DNAs normal single-cell samples were chosen test our (SSP-PGD/S) method with two widely used whole-genome amplification (WGA) kits. A total 557 single blastomeres collected from vitro fertilization (IVF) couples, their WGA products...
Chromosome translocations are rare but frequently associated with infertility. The objective of this study is to investigate the feasibility using chromosomal microarray analysis (CMA) on products conception (POC) samples as an indicator parental balanced translocation. From January 2011 December 2016, CMA Affymetrix Cytoscan™750K array was performed 1294 POC in our hospital. Karyotyping and fluorescence situ hybridization (FISH) blood were validate origin subchromosomal copy number...
Endometriosis is a chronic estrogen-dependent inflammatory disorder that negatively affects the quality of life in women. The Wenjing decoction (WJD) traditional Chinese medicine has been shown to have therapeutic effect on endometriosis. Our study systematically explored mechanism WJD against endometriosis using network pharmacology approach. Potentially bioactive compounds and their possible targets were retrieved from Traditional Medicine System Pharmacology Database Analysis Platform....
The present study investigated the effect of Modified Dihuang Decoction in improving ovarian reserve mice through Bcl-2-related mitochondrial apoptosis pathway. Forty-eight adult female BALB/c were randomly divided into following six groups with eight each group: a blank group, model femoston group(three cycles treatment 0.13 mg·kg~(-1) estradiol tablets for 2 days and 1.43 dydrogesterone 3 days), high(64.74 g·kg~(-1))-, medium(43.16 low-dose(21.58 g·kg~(-1)) groups. Mice other except group...
Objective: Bushen Zhuyun Decoction (BSZY), a traditional Chinese herbal prescription has shown promising effects on gynecological infertility, but the mechanism for endometrial receptivity is still unclear. This study aimed to investigate regulatory of BSZY receptivity, which plays key role in colonization embryo, and its mechanisms associated with NF- κB/NLRP3 pathway. Methods: SD rats at reproductive age affected was established using mifepristone (RU486), were evaluated by H&E...
Background: Reproductive endocrine disorder can impair endometrial receptivity, preventing embryo implantation and increasing miscarriage risk. Impaired receptivity contributes significantly to female infertility. Inflammatory signaling pathways including the IL-6/STAT3 pathway help embryos implant. Therefore, it is crucial explore relationship between receptivity. Objective: To investigate mechanism by which Bushen Zhuyun decoction (BSZY) enhances in rats through pathway. Methods:...
Chromosomal abnormalities and Y chromosome microdeletions are considered to be the two more common genetic causes of spermatogenic failure. However, relationship between chromosomal aberrations is still unclear. This study was investigate incidence characteristics in infertile men, explore whether there a correlation defects A 7-year retrospective conducted on 5465 men with nonobstructive azoospermia or oligozoospermia. Karyotype analysis peripheral blood lymphocytes performed by standard...
Luteal phase deficiency (LPD) is a significant contributor to infertility and miscarriage. Bushen Zhuyun Prescription (BSZY) traditional Chinese medicine formula that has potential treat LPD. To investigate the effect of BSZY in treating LPD, SD rats with complete estrous cycles were divided into blank, model, dydrogesterone (DYD), high-dose (BSZY-HD), low-dose (BSZY-LD) groups. All groups received mifepristone gavage except for blank group. The pathological changes observed hypothalamus,...
Background: Low-pass genome sequencing (LP GS) is an alternative to chromosomal microarray analysis (CMA). However, validations of LP GS as a prenatal diagnostic test for amniotic fluid are rare. Moreover, depth in diagnosis has not been evaluated.Methods: The performance was compared with CMA using 375 samples. Then, evaluated by downsampling.Findings: and had the same yield (8.3%; 31/375). showed all copy number variations (CNVs) detected 6 additional VUS (variant uncertain significance)...