A5052702020- Dental materials and restorations
- Dental Implant Techniques and Outcomes
- Bone Tissue Engineering Materials
- Dental Erosion and Treatment
- Endodontics and Root Canal Treatments
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Orthodontics and Dentofacial Orthopedics
- Advanced ceramic materials synthesis
- Dental Research and COVID-19
- Rock Mechanics and Modeling
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Crystallography and molecular interactions
- Catalytic Cross-Coupling Reactions
- Advanced materials and composites
- Cyclization and Aryne Chemistry
- Spine and Intervertebral Disc Pathology
- Catalytic Alkyne Reactions
- Innovative concrete reinforcement materials
- Bone Metabolism and Diseases
- Orthopaedic implants and arthroplasty
- Geotechnical and Geomechanical Engineering
- Chemical Synthesis and Characterization
- Spinal Fractures and Fixation Techniques
- Concrete and Cement Materials Research
Nanjing Medical University
2016-2025
Zhejiang Chinese Medical University
2021-2024
Jiangsu Province Hospital
2021-2024
Stomatology Hospital
2022-2024
Soochow University
2022-2023
First Affiliated Hospital of Soochow University
2022-2023
Hangzhou Medical College
2023
Soochow University
2022
Taiyuan University of Technology
2020
Wenzhou Hospital of Traditional Chinese Medicine
2018-2019
Pulmonary fibrosis (PF) is a fatal disease with increasing incidence, poor prognosis, and unclear pathogenesis. Our previous research demonstrated the beneficial effects of natural cyclopeptide Heterophyllin B (HB) in PF. However, precise mechanism by which HB exerts its PF remains unclear. study revealed HB's alleviating symptoms restoring intestinal mucosal barrier. Subsequently, microbiota-dependent antifibrotic efficacy was verified using various delivery routes, antibiotic treatments,...
Inflammation, abnormal cholesterol metabolism, and macrophage infiltration are involved in the destruction of extracellular matrix nucleus pulposus (NP), culminating intervertebral disc degeneration (IDD). Whether nimbolide (Nim), a natural extract, can alleviate IDD is unclear. In this study, we demonstrated that Nim promotes efflux inhibits activation nuclear factor kappa B (NF-κB) mitogen-activated protein kinase (MAPK) signaling pathways by activating sirtuin 1 (SIRT1) cells (NPCs)...
Heat shock protein 90 plays critical roles in client maturation, signal transduction, folding and degradation, morphological evolution; however, its function human sperm is not fully understood. Therefore, our objective this study was to elucidate the mechanism by which heat exerts effects on function. By performing indirect immunofluorescence staining, we found that localized primarily neck, midpiece, tail regions of sperm, expression increased with increasing incubation time under...
Acute lung injury (ALI) often leads to high mortality, and there is as yet no effective drug treatment. The present study aimed investigate protective effects of mogroside IIIE (MGIIIE, a cucurbitane-type triterpenoid from Siraitia grosvenorii Fruits) in experimental ALI its underlying mechanism. MGIIIE (1, 10 0r 20 mg/kg) was orally administered for 1 h before single intratracheal administration lipopolysaccharide (LPS, 5 mg/kg). treatment dose-dependently suppressed pulmonary oedema,...
A pair of racemic indolizidine enantiomers, (±)-homocrepidine (1), and a piperidine derivative, homocrepidine B (2), were isolated from Dendrobium crepidatum along with the known alkaloid crepidine (3). The mixture 1 was separated into (+)-1 (−)-1, by HPLC using chiral chromatographic substrate, which represents first successful example resolving mixtures. absolute configurations (−)-1 assigned single-crystal X-ray diffraction data. evaluation anti-inflammatory activity LPS-induced RAW 264.7...
Purpose To examine the durability of composite bonding to zirconia after artificial aging using different products containing 10-methacryloyloxydecyl dihydrogen phosphate (MDP). Materials and methods Conditioning were: none (control [Ctr]; Clearfil SA Luting [CSL]; Panavia Plus [PSLP]), MDP-containing primers (Z-Prime [ZP]; Ceramic Primer [CCP]), universal adhesives (Single Bond Universal [SBU]; [CUB]). For Ctr, ZP, CCP, SBU, CUB groups, Y-TZP plates were bonded with MDP-free cement....
Pulmonary fibrosis is common in a variety of inflammatory lung diseases, there currently no effective clinical drug treatment. It has been reported that the ethanol extract Eclipta prostrata L. can improve collagen deposition and pathology induced by bleomycin (BLM) mice. In present study, we studied whether wedelolactone (WEL), major coumarin ingredient E. prostrata, provided protection against BLM-induced pulmonary fibrosis. ICR or C57/BL6 strain mice were treated with BLM to establish...
Excessive reactive oxygen species (ROS) in nucleus pulposus cells (NPCs) promote extracellular matrix (ECM) degradation and cellular inflammatory responses by activating a variety of pathways, ultimately inducing cell apoptosis leading to the development low back pain. Here, we designed fabricated an isoginkgetin-loaded ROS-responsive delivery system (IGK@SeNP) based on diselenide block copolymers. Successfully encapsulated IGK was released intelligently rapidly microenvironment with high...
To assess the influence of various factors on bond strength glass-based ceramics and develop a model that can predict values using machine learning (ML). The lithium disilicate-reinforced glass–ceramics were collected from existing literature. Nineteen features listed, 9 ML algorithms, including logistic regression, k-nearest neighbors, support vector machine, decision tree, ensemble methods (extra trees, random forest, gradient boosting, extreme boosting), multilayer perceptron, employed....
Abstract Background: To assess in vitro the dentine bond strength and microleakage of three Class V restorations viz. flowable composite, compomer glass ionomer cement. Methods: Eighteen specimens were prepared randomly distributed among groups. Three kinds restoration materials each bonded on surfaces groups as per manufacturers’ instructions. Group Aelite: Tyrian SPE (a no‐rinse, self‐priming etchant) + One Step Plus (an universal dental adhesive) Aeliteflo composite); Dyract: Prime &...
This study aimed to investigate and compare the resin bond strengths of zirconia conditioned as follows: alumina sandblasting; sandblasting+application 10-MDP-containing primer; Z-Prime Plus or Metal/Zirconia Primer (new primers); tribochemical silica coating+silanization; hot acid etching in three different combinations [H2SO4/(NH4)2SO4, HF/HNO3, H2SO4/HF/HNO3]+application primer. Shear (SBS) after water storage for 24 h 40 days were measured assess bonding performance. Surface chemical...
Idiopathic pulmonary fibrosis is a progressive fibrotic lung disease, and eventually most patients develop respiratory failure with median survival rate of 2 to 3 years after diagnosis due the lack clinically effective therapies. Mogroside IIIE (MGIIIE), cucurbitane-type compound, was isolated from Siraitia grosvenorii MGIIIE has shown strongest inhibition nitric oxide release, crucial inflammatory factor, lipopolysaccharide (LPS)-treated RAW264.7 cells compared other mogrosides. In mouse...