Curcumin alleviates septic acute kidney injury (SAKI); however, the underlying mechanism remained unclear. To explore this, SAKI cell model and mice were conducted by using LPS cecal ligation puncture (CLP), respectively. Cell counting kit-8 (CCK-8) enzyme-linked immunosorbent assay (ELISA) assays indicated that reduced viability, but upregulated levels of tumor necrosis factor (TNF)-α interleukin (IL)-6, whereas pretreatment had no effect on TNF-α IL-6. Further showed partly attenuated...

In the current era of global climate change, environmental stresses, especially drought and salt, have impaired growth productivity crops, e.g., cotton. Understanding mechanisms plants' adaptation to these abiotic stresses is crucial breed stress-tolerant crop species. present study, integrated metabolomics, lipidomics, mass spectrometry imaging (MSI) were used discover spatial distribution differential metabolites lipids in two cottonseed cultivars with contrasting salt tolerance...

Selenium participates in the antioxidant defense mainly through a class of selenoproteins, including thioredoxin reductase. Epigallocatechin-3-gallate (EGCG) is most abundant and biologically active catechin green tea. Depending upon dose biological systems, EGCG may function either as an or inducer via its pro-oxidant action other unidentified mechanisms. By manipulating selenium status, present study investigated interactions with systems system comprising reductase, glutathione reductase...

The association between social media usage and the risk of depressive symptoms has attracted increasing attention. WeChat is a popular software in China. impact using posting moments on developing among community-based middle-aged older adults China unknown. objective was to assess A prospective national cohort study designed based data obtained from fourth fifth waves Health Retirement Longitudinal Study (CHARLS). strength estimated by modified Poisson regressions. Depressive were...

Our recent studies indicate that the transient receptor potential vanilloid type 1 (TRPV1) channel may act as a regulator of monocyte/macrophage recruitment to reduce renal injury in salt-sensitive hypertension. This study tests hypothesis deletion TRPV1 exaggerates hypertension-induced due enhanced inflammatory responses via monocyte chemoattractant protein-1 (MCP-1)/C-C chemokine 2 (CCR2)-dependent pathways. Wild (WT) and TRPV1-null mutant (TRPV1(-/-)) mice were subjected uninephrectomy...

The aim of this study was to evaluate the association functional expression TRPM7 with nasopharyngeal carcinoma (NPC) growth. We examined correlation cell growth and proliferation, cycle, apoptosis in vitro NPC lines tumorigenesis mice by conducting experiments further analyzing tumor volume explored see whether there is any positive knockdown cells their sensitivity radiation. found that a critical requirement for physiological processes such as resistance apoptosis, proliferation. also...

The ameliorative effects and its mitigation mechanisms of selenium (Se) on cadmium (Cd) toxicity in cucumber seedlings were studied through hydroponic experiments. Cd other mineral nutrient concentrations, antioxidant enzyme activities, contents studied. results revealed that exogenous Se significantly decreased the concentrations all tissues, especially leaves. Moreover, (Cd + Se) could increase Zn, Na, leaf Cu, stem/root Fe, Ca, Mg concentrations; reduce concentration, compared with alone...

A hydroponic experiment was carried out to study the ameliorative effects of exogenous glycinebetaine (GB) upon cadmium (Cd) toxicity in cucumber seedlings. The results indicated that 50 μmol/L Cd stress decreased soil plant analysis development (SPAD) value, height, root length, seedling biomass, activities ascorbate peroxidase (APX) and ATPase leaves, stems roots; however, increased (POD) superoxide dismutase (SOD) all tissues, catalase (CAT) stems/roots. Moreover, also elevated leaf/root...

OBJECTIVE To explore the effect of vinyl chloride on reproductive and endocrine system male rats. METHODS Male SD rats were administered with at dose (0, 10, 100, 1000 mg/kg) for 14 28 days, respectively. The levels testosterone (T), inhibin B, luteinizing hormone (LH), follicle stimulating (FSH) estradiol (E2) measured in serum testis homogenates. Histopathological examinations performed electron microscopy. RESULTS Compared control group after 14-day exposure, T E2 1000, 10 mg/kg groups...

Objective To study the status on economic burden of diarrhea in Zhejiang province so as to provide evidence for allocation health resource well decision-making issues. Methods Multi-phases stratified random cluster sampling was used select samples population. Data collected incidence last two weeks related cost due medical care etc. Results The overall (person per year) 0.26, with 0.29 rural and 0.22 urban areas respectively. children less than 5 0.66 year), higher any age groups. average...

To determine whether deletion of TRPV4 attenuates angiotensin II (Ang II)‐induced renal injury, Ang was infused systemically into wild type (WT) and TRPV4‐null mutant (TRPV4 ‐/‐ ) mice for 4 weeks. Systolic blood pressure increased in II‐treated WT or with the similar degree (P>0.05). treatment urinary excretion albumin 8‐isoprostane, decreased creatinine clearance both a greater magnitude former strain (P<0.05). Periodic acid‐Schiff Masson's trichrome staining showed that kidneys...

To determine the effects of transient receptor potential vanilloid type 1 (TRPV1) channel ablation and a chemokine 2 (CCR2) antagonist on salt-sensitive hypertension-induced renal injury.Wild-type (WT) TRPV1-null mutant (TRPV1(-/-)) mice were subjected to uninephrectomy deoxycorticosterone acetate (DOCA)-salt treatment for 4 weeks with or without CCR2 antagonist, RS504393 (n=8 all groups). Sham WT TRPV1(-/-) (both n=7) underwent receiving DOCA saline. Systolic blood pressure, urinary...