A5100705122- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Respiratory viral infections research
- Pediatric health and respiratory diseases
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Migration, Aging, and Tourism Studies
- Global Health Care Issues
- Intergenerational Family Dynamics and Caregiving
- Health disparities and outcomes
- Crystallography and molecular interactions
- Drug Transport and Resistance Mechanisms
- IL-33, ST2, and ILC Pathways
- Virology and Viral Diseases
- Immune Response and Inflammation
- Congenital Diaphragmatic Hernia Studies
- Immune Cell Function and Interaction
- ECG Monitoring and Analysis
- Vasculitis and related conditions
- Global Educational Reforms and Inequalities
- Oropharyngeal Anatomy and Pathologies
- Machine Fault Diagnosis Techniques
- Carbon and Quantum Dots Applications
- Cholesterol and Lipid Metabolism
- Renal Diseases and Glomerulopathies
Tongji Hospital
2022-2025
Huazhong University of Science and Technology
2022-2025
Fourth Hospital of Hebei Medical University
2023
Hebei Medical University
2023
Second Affiliated Hospital of Soochow University
2022
University of Waterloo
2021-2022
Soochow University
2022
Actua
2022
University of Chicago
2022
National University of Singapore
2008-2020
IntroductionWe report the final results of phase 3 IMpower132 study evaluating atezolizumab plus carboplatin or cisplatin pemetrexed (APP) in patients with nonsquamous NSCLC.MethodsChemotherapy-naive stage IV NSCLC without sensitizing EGFR ALK genetic alterations were randomized a one-to-one ratio to receive four six cycles (PP) APP every weeks, followed by maintenance therapy alone. Co-primary end points overall survival (OS) and investigator-assessed progression-free (PFS).ResultsThe...
Respiratory syncytial virus (RSV) is the most important cause of severe, lower respiratory tract infections in infants, and RSV have been associated with chronic wheezing asthma during childhood. However, mechanism RSV-induced airway inflammation hyperresponsiveness (AHR) poorly understood. Furthermore, there are presently neither effective vaccines nor drugs available for prevention or treatment infections. In this study, we investigated effect plant extract resveratrol as a means...
The conversion of primary bile acids to secondary by the gut microbiota has been implicated in colonic inflammation. This study investigated role related acid metabolism inflammation both patients with inflammatory bowel disease (IBD) and a murine model dextran sulfate sodium (DSS)-induced colitis. Bile fecal samples from IBD DSS-induced colitis mice, without antibiotic treatment, were analyzed using ultraperformance liquid chromatography-mass spectrometry (UPLC-MS). composition DSS-colitis...
Singapore is one of the fastest-aging populations due to increased life expectancy and lowered fertility. Lifestyle changes increase burden chronic diseases disability. These have important implications for social protection systems. The goal this paper model future functional disability healthcare expenditures based on current trends. To project health, hospitalization spending elders, we adapted Future Elderly Model (FEM) Singapore. FEM a dynamic Markov microsimulation developed in US. Our...
Background Glucocorticoids (GCs) are a first-line treatment for asthma their anti-inflammatory effects, but they also hinder the repair of airway epithelial injury. The protein GC-induced leucine zipper (GILZ) is reported to inhibit activation mitogen-activated kinase (MAPK)-extracellular-signal-regulated (ERK) signaling pathway, which promotes cells around damaged areas. We investigated whether inhibition imposed by GC dexamethasone (DEX) mediated GILZ. Methods tested effect DEX on...
The prevalence of autoimmune hepatitis (AIH) is increasing, yet specific pharmacotherapies remain to be explored. present study aimed investigate the effects sophoricoside (SOP), a bioactive component medical herbs, on AIH and elucidate underlying mechanisms. Bioinformatic approaches were used predict potential targets regulatory mechanisms SOP AIH. evaluated by determining expression levels inflammatory cytokines, histological liver injury hepatic fibrosis in an improved chronic cytochrome...
Epidemiologic studies have demonstrated that some bacteria colonization or infections in early-life increased the risk for subsequent asthma development. However, little is known about mechanisms by which bacterial infection increases this risk. The aim of study was to investigate effect neonatal Streptococcus pneumoniae on development adulthood asthma, and explore possible mechanism. A non-lethal S. lung established intranasal inoculation (1-week-old) female mice with D39. Mice were...
Objective Evaluation of the endoscopic features Crohn’s disease (CD) and ulcerative colitis (UC) is key diagnostic approach in distinguishing these two diseases. However, making differentiation images requires precise interpretation by experienced clinicians, which remains a challenge to date. Therefore, this study aimed establish convolutional neural network (CNN)-based model facilitate classification among CD, UC, healthy controls based on colonoscopy images. Methods A total 15,330...
Abstract The substantial social and economic burden attributable to smoking is well‐known, with heavy smokers at higher risk of chronic disease premature mortality than light nonsmokers. In aging societies high rates male such as in East Asia, a leading preventable factor for extending lives (including work‐lives) healthy aging. However, little known about whether interventions targeted relative lead disproportionately larger improvements life expectancy prevalence diseases how the effects...
7-Valent pneumococcal conjugate vaccine (PCV7) immunization in adulthood can inhibit allergic asthma mouse model. The aim of this study is to investigate the effects infant PCV7 on young CD4(+)T cell subsets a murine airway disease (AAD) Our indicated that inflammation and hyperresponsiveness (AHR) by inducing production Foxp3(+)Treg, Th1 cells their cytokines IL-10 IFN-γ, inhibiting Th2, Th17 IL-13 IL-17A BALB/c mice These results suggested may serve as an effective measure prevent AAD.
Background Regulatory T cells (Treg cells), which are essential for regulation of immune response to respiratory syncytial virus (RSV) infection, promoted by pharyngeal commensal pneumococcus. The effects microflora disruption antibiotics on airway responsiveness and relative responses after RSV infection have not been clarified. Methods Female BALB/c mice (aged 3 weeks) were infected with then treated either oral or double distilled water (ddH2O) from 1 d post (pi). Changes in analyzed...
Objectives: This study aimed to investigate the role of non-linear dynamic analysis (NDA) electroencephalogram (EEG) in predicting patient outcome unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS). Methods: was a prospective longitudinal cohort study. A total 98 64 UWS MCS cases, respectively, were assessed. During admission, EEGs acquired under eyes-closed pain stimulation conditions. EEG nonlinear indices, including approximate entropy (ApEn) cross-ApEn,...
Objective. It is well known that IL-4 and IL-13 play critical roles in the pathogenesis of asthma. In this study, by overexpressing murine receptor antagonist (mIL-4RA), a competitive for both IL-13, we investigated therapeutic effects mIL-4RA on mouse asthmatic airway inflammation. Material methods. BALB/c mice were randomly divided into four groups: healthy control mice; ovalbumin (OVA) sensitized/challenged OVA intratracheally administered with plasmid (mIL-4RA group); (control group)....
While genetic polymorphisms in Toll-like Receptor 4 (TLR4) have been demonstrated to play an important role respiratory syncytial virus (RSV) infections Western populations, the association between TLR4 and RSV has not investigated Chinese patient populations. The study presented here identifies investigates of polymorphism with infection a infant population.One-hundred ninety-six infants hospitalized 311 healthy control subjects were enrolled this study. Genetic 5' untranslated region...
We report on a study of the C 1s shake-up spectrum for bulk films (C59N)2 and find previously unobserved peak at 1.05 eV from main line. This new can be attributed to binding energy sp2-like carbon atoms bound directly nitrogen. further analyse by comparing it convolution valence band x-ray absorption spectra, which closely mimics transitions possible in presence core hole. The represents on-site excitons, their onset is consistent with optical gap 1.4 eV.