A5017087538- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Mycotoxins in Agriculture and Food
- Meat and Animal Product Quality
- Insect Utilization and Effects
- Mast cells and histamine
- Protein Hydrolysis and Bioactive Peptides
- Fungal Plant Pathogen Control
- Coccidia and coccidiosis research
- Probiotics and Fermented Foods
- Transgenic Plants and Applications
- Synthesis and Biological Activity
- Insect and Pesticide Research
- Monoclonal and Polyclonal Antibodies Research
- Proteins in Food Systems
- Eosinophilic Esophagitis
- Polysaccharides and Plant Cell Walls
Jimei University
2017-2025
College of Marin
2025
The enzymatic cross-linking of proteins to form high-molecular-weight compounds may alter their sensitization potential. IgG-/IgE-binding activity, digestibility, allergenicity, and oral tolerance cross-linked tropomyosin with tyrosinase (CTC) or horseradish peroxidase (CHP) were investigated. ELISA results demonstrated CTC CHP reduced its IgE-binding activity by 34.5 ± 1.8 63.5 0.6%, respectively. Compared native CTC, was more easily digested into small fragments; decreased the...
Scylla paramamosain, a crustacean of substantial importance, is frequent trigger food allergies. This study examined the molecular and immunological properties troponin C from S. paramamosain (Scy p TnC) as an allergen. The findings indicated that thermal stability Scy TnC comprised 150 amino acids facilitated induction CD63/CD203c in basophils crab allergy patients. Furthermore, treatment with chemical denaturants caused structural degradation, which resulted diminished IgG binding...
Sarcoplasmic calcium-binding protein identified in Crassostrea angulata (Cra a 4), is stable allergen; the methods to reduce its allergenicity are still limited. The present study aimed develop hypoallergenic enzymatic hydrolyzate of Cra 4 (ECra 4) by enzymolysis. After screening proteases bioinformatics and optimization enzymolysis conditions, ECra was obtained with Trypsin. Further, used stimulate splenocytes from 4-sensitized mice, findings that could CD4+ T-cell proliferation, inhibit...
T cells play pivotal roles in inflammation’s initiation and progression. Exploring natural compounds that regulate cell function is crucial for preventing treating inflammation. Herein, we report Alternariol (AOH), a marine-derived secondary metabolite, exerts an anti-inflammatory activity by targeting function. Using ovalbumin (OVA)-induced OT-II CD4+ activation model, demonstrated AOH potently suppresses proliferation cytokine secretion, mildly promotes apoptosis, spares antigen...
Haliotis discus hannai tropomyosin (HTM), Alectryonella plicatula (ATM), and Mimachlamys nobilis (MTM) were reported as significant seafood allergens capable of eliciting severe allergic reactions. However, studies cross-reactivity epitope mapping among them are notably limited. This study discovered their property through inhibition IgG/IgE binding capacity promotion specific CD4+T-cell proliferation. For T-cell epitopes, 3, 4, 3 epitopes identified from the splenocytes mice immunized with...
Tropomyosin (TM) is the main allergen in shrimp (Litopenaeus vannamei). In this study, effects of allergenicity and structure TM by glycosylation (GOS-TM), phosphate treatment (SP-TM), combined with (GOS-SP-TM) were investigated. Compared to GOS-TM SP-TM, IgG/IgE binding capacity GOS-SP-TM was significantly decreased 63.9 ± 2.0 49.7 2.7%, respectively. Meanwhile, α-helix content reduced, surface hydrophobicity increased, 10 specific amino acids (K30, K38, S39, K48, K66, K74, K128, K161,...
Food allergy is one of the hot issues in field food safety, and there have been a lot concerns on how to reduce allergenicity allergens. processing can change allergens matrix. In this study, ten IgE linear epitopes major allergen tropomyosin (TM) Perna viridis were identified by bioinformatics prediction serological experiments. The transglutaminase-catalyzed glycosylation modification sites glutamine, lysine arginine highly represented TM. matrix was treated with glycosylation. This...
Scy p 8 (triosephosphate isomerase) as a crab allergen in inducing distinct T-helper (Th) cell differentiation and linear epitope associated with allergenicity remain elusive. In this study, mice sensitized exhibited significantly upregulated levels of IgE, IgG1, IL-4 release, Th2 immune response. Moreover, the release IFN-γ (Th1) Treg cells were downregulated, while IL-17A (Th17) was upregulated, indicating that disrupted Th1/Th2 balance Th17/Treg mice. Furthermore, bioinformatics...
Tropomyosin (TM) has been determined as the major allergen in
The prevalence of food allergies has grown dramatically over the past decade. Recently, studies have shown potential marine substances to alleviate allergies. We utilized a rat basophilic leukemia (RBL)-2H3 model evaluate antiallergic effects alternariol monomethyl ether (AME) extracted from fungi Alternaria sp. Our results showed that AME attenuated allergy symptoms in mice and reduced histamine release serum. population mast cells spleen mesenteric lymph nodes was considerably reduced....
F1-ESP-3 exerts anti allergic activity in vivo .
, a prevalent aquatic delicacy, is known to elicit allergic reactions in certain individuals. Nevertheless, the investigation into its allergenic components has remained notably inadequate. In research, an approximately 35 kDa heat-stable protein of