A5053408455- Oral Health Pathology and Treatment
- Head and Neck Cancer Studies
- Oral and Maxillofacial Pathology
- Cancer-related molecular mechanisms research
- Oral and gingival health research
- Autoimmune Bullous Skin Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Immune Response and Inflammation
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- NF-κB Signaling Pathways
- Immune Cell Function and Interaction
- Protease and Inhibitor Mechanisms
- Inflammasome and immune disorders
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Cancer and Skin Lesions
- Cell death mechanisms and regulation
- Epigenetics and DNA Methylation
- Cytokine Signaling Pathways and Interactions
- Liver Disease Diagnosis and Treatment
- Fibroblast Growth Factor Research
- Salivary Gland Disorders and Functions
Chinese Academy of Medical Sciences & Peking Union Medical College
2006-2025
Sichuan University
2016-2025
Xiamen University
2022-2025
Wuhan University
2019-2024
Guangdong Pharmaceutical University
2022-2023
The First People's Hospital of Guiyang
2023
State Key Laboratory of Oral Diseases
2010-2022
Jimei University
2020-2022
Dalian Medical University
2021-2022
Chongqing Medical University
2021-2022
Two subsets of conventional dendritic cells (cDCs) with distinct cell surface markers and functions exist in mouse human. The two cDCs are specialized antigen-presenting that initiate T immunity tolerance. In the mouse, a migratory cDC precursor (pre-CDC) originates from defined progenitors bone marrow (BM). Small numbers short-lived pre-CDCs travel through blood replace peripheral organs, maintaining homeostasis highly dynamic pool. However, identity distribution immediate to human has not...
Receptor for activated C kinase 1 (RACK1) has been shown to promote oral squamous cell carcinoma (OSCC) progression, and RACK1 expression levels have negatively correlated with prognosis in patients OSCC. Here, we investigated the impact of OSCC on recruitment differentiation tumor-associated macrophages. High cells increased M2 macrophage infiltration tumor samples from a clinical cohort study. Moreover, combination M2/M1 ratio could successfully predict high inhibited migration THP-1...
Chronic neuropathic pain is a frequent sequel to peripheral nerve injury and maladaptive nervous system function. Divanillyl sulfone (DS), novel structural derivative of 4,4'-dihydroxydibenzyl sulfoxide from traditional Chinese medicine Gastrodia elata with anti-nociceptive effects, significantly alleviated following intrathecal injection. Here, we aimed investigate the underlying mechanisms DS against pain.A chronic constrictive (CCI) mouse model induced by sciatic ligation was performed...
Janus kinases (JAKs) play a critical role in immune responses by relaying signals from more than 50 cytokines, making them attractive therapeutic targets for autoimmune diseases. Although approved JAK inhibitors have demonstrated clinical efficacy, they target broad spectrum of which results side effects. Therefore, next-generation maintain while sparing adverse events need to be developed. Among members the family, JAK3 only regulates narrow γc cytokines and becomes potentially ideal...
CD8+ tissue-resident memory T (CD8+ Trm) cells play key roles in many immune-inflammation-related diseases. However, their characteristics the pathological process of oral lichen planus (OLP) remains unclear. Therefore, we investigated function Trm OLP. By using single-cell RNA sequencing profiling and spatial transcriptomics, revealed that were predominantly located lamina propria adjacent to basement membrane significantly increased patients with erosive (EOLP) compared those non-erosive...
Conventional oligonucleotide based drug delivery systems suffer from lengthy synthetic protocols, high cost, and poor chemical or enzymatic stability under certain circumstances. Canonical free individual nucleosides cannot form stable nanostructures in aqueous solution as vehicles. Here, we report the development of a monomeric self-assembled nucleoside nanoparticle (SNNP) into an efficient system which has currently no parallel such field. This was achieved using l-configurational...
T cells play pivotal roles in inflammation’s initiation and progression. Exploring natural compounds that regulate cell function is crucial for preventing treating inflammation. Herein, we report Alternariol (AOH), a marine-derived secondary metabolite, exerts an anti-inflammatory activity by targeting function. Using ovalbumin (OVA)-induced OT-II CD4+ activation model, demonstrated AOH potently suppresses proliferation cytokine secretion, mildly promotes apoptosis, spares antigen...
OSCC is one of the most common malignancies and numerous clinical agents currently applied in combinative chemotherapy. Here we reported a novel therapeutic strategy, SAHA DDP-loaded PECE (SAHA-DDP/PECE), can improve effects intratumorally chemotherapy on cell xenografts.The objective this study was to evaluate efficacy SAHA-DDP/PECE situ controlled drug delivery system xenografts.A biodegradable thermosensitive hydrogel successfully developed load DDP. Tumor-beared mice were administered...
Abstract Background Isotalatizidine is a representative C 19 -diterpenoid alkaloid extracted from the lateral roots of Aconitum carmichaelii , which has been widely used to treat various diseases on account its analgesic, anti-inflammatory, anti-rheumatic, and immunosuppressive properties. The aim this study was evaluate analgesic effect isotalatizidine underlying mechanisms against neuropathic pain. Methods A chronic constrictive injury (CCI)-induced model pain established in mice, limb...
Atherosclerosis (AS), with high risk of stroke or cerebrovascular disease, is one the most common causes death worldwide. Increasing evidence shows that long non-coding RNA (lncRNA) antisense in INK4 locus (ANRIL) related to atherothrombotic susceptibility and contributes AS progression. However, underlying mechanism was not explained yet.Human aorta vascular smooth muscle cells (HA-VSMCs) human umbilical vein endothelial (HUVECs) were treated oxidized Low Density Lipoprotein (ox-LDL)...