A5071553452- Oral Health Pathology and Treatment
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Oral and Maxillofacial Pathology
- Circular RNAs in diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Immune cells in cancer
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Immunotherapy and Biomarkers
- Genetic and Kidney Cyst Diseases
- Environmental Impact and Sustainability
- COVID-19 diagnosis using AI
- Neurosurgical Procedures and Complications
- Nuclear Receptors and Signaling
- NF-κB Signaling Pathways
- Epigenetics and DNA Methylation
- Agriculture Sustainability and Environmental Impact
- Salivary Gland Disorders and Functions
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Proteomics Techniques and Applications
- Forest Management and Policy
- COVID-19 epidemiological studies
- dental development and anomalies
Hebei Agricultural University
2024
Shandong University of Traditional Chinese Medicine
2024
Hohai University
2024
Anhui University of Technology
2024
Zhejiang University
2021-2022
Stomatology Hospital
2021-2022
Sichuan University
2016-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2022
Second Affiliated Hospital of Nanchang University
2018
Nanchang University
2018
Receptor for activated C kinase 1 (RACK1) has been shown to promote oral squamous cell carcinoma (OSCC) progression, and RACK1 expression levels have negatively correlated with prognosis in patients OSCC. Here, we investigated the impact of OSCC on recruitment differentiation tumor-associated macrophages. High cells increased M2 macrophage infiltration tumor samples from a clinical cohort study. Moreover, combination M2/M1 ratio could successfully predict high inhibited migration THP-1...
Antioxidants represented by kaempferol have been shown to be effective against atherosclerosis (AS). However, the underlying mechanisms still remain unclear.
Since the COVID-19 epidemic is still expanding around world and poses a serious threat to human life health, it necessary for us carry out transmission prediction, whole genome sequence analysis, public psychological stress assessment 2019-nCoV. However, prediction models are insufficiently accurate characteristics not clear, difficult dynamically assess state under 2019-nCoV epidemic. Therefore, this study develops 2019nCoVAS web service ( <uri xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Metastasis, a powerful prognostic indicator of oral squamous cell carcinoma (OSCC), is chiefly responsible for poor cancer outcomes. Despite an increasing number studies examining the mechanisms underlying outcomes, development potent strategies hindered by insufficient characterization crucial regulators. Long noncoding RNAs (lncRNAs) have recently been gaining interest as significant modulators OSCC metastasis; however, detailed lncRNA-mediated metastasis remain relatively uncharacterized....
Aim: To investigate diagnostic value of preoperative inflammatory biomarkers in pancreatic cancer (PCC). Materials & methods: Preoperative circulating Alb/Fib ratio, neutrophil/lymphocyte ratio (NLR), derived NLR (dNLR), platelet/lymphocyte and lymphocyte/monocyte were detected calculated 226 PCC individuals, 232 healthy controls 142 additional controls. Receiver-operating characteristic curve area under the (AUC) used to evaluate efficacy PCC. Results: Combined dNLR Alb could effectively...
Abstract Oral squamous cell carcinoma (OSCC) is a leading cause of cancer-related deaths worldwide, with 500 000 new cases each year. However, the mechanisms underlying OSCC development are relatively unknown. In this study, matrix-assisted laser desorption ionization imaging mass spectrometry (MALDI-IMS)-based proteomic strategy was used to profile differentially expressed peptides/proteins between tissues and their adjacent noncancerous tissues. Sixty-seven unique peptide peaks five...
The driving force of the malignant transformation epithelial cells during oral submucous fibrosis (OSF) is an unsettled debate. We hypothesized that expression and accumulation cancer stem (CSCs) are accompanied by atrophy in OSF.The levels Ki67 (proliferation marker), SOX2, Bmi1 (CSC marker) epithelium early, middle, late stages OSF were measured immunohistochemistry. At same time, we focused on three proteins patients with benign hyperkeratosis dysplasia.The clinical cohort study showed...
Aim: To investigate the diagnostic roles of circulating inflammatory biomarkers in gallbladder carcinoma (GBC). Patients & methods: Circulating cell count, fibrinogen, albumin, carcinoembryonic antigen (CEA) and CA199 were measured, neutrophil-to-lymphocyte ratio (NLR), dNLR, PLR, LMR Alb-to-fib (AFR) calculated 306 GBC patients, healthy 305 benign controls. The reciever operating characteristic curve was used to determine accuracy them. Results: area under curves combined AFR, dNLR...
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in world, 5-year survival rate of patients with HNSCC still about 50% due to frequent metastasis recurrence. Circular RNAs (circRNAs) have been characterized as key regulators gene expression numerous malignancies. However, role circRNA remains largely unknown. Here, we demonstrated that circRFWD3 was significantly upregulated tissues lines by microarray analysis qPCR. Notably, high related highly aggressive lymph...
Head and neck squamous cell carcinoma(HNSCC) is among the most common malignances worldwide. Patients with HNSCC often develop primary tumors at multiple sites have tendency for local recurrences following curative resectional surgery. Field cancerization theory presumes that, after repeated carcinogenic exposures, entire superficialepitheliium of upper aerodigestive tract has an increased risk developing (pre)malignant lesions because genetic abnormalities. This theorywell explains strong...
Beef production is the primary contributor to greenhouse gas emissions in animal husbandry. But carbon emission distribution, potential for reduction, and pathways main links of beef cattle industry chain are not yet clear. Balancing efficiency fairness while taking tailored reduction paths according local conditions crucial helping achieve low-carbon husbandry “dual carbon” goals. This research adopts an perspective assess four leading regions’ emissions, potential, China from 2007 2021. We...
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Background: Sex determining region Y-BOX2 (SOX2), a regulator of the self-renewal ability stem cells, plays compelling role in initiation and development cancer. However, little is known about network controlling SOX2 oral squamous cell carcinoma (OSCC) development.Method: In this study, we conducted retrospective cohort 229 OSCC patients from two independent Chinese centers May 2003 to August 2012. expression these samples was determined by immunostaining. Univariate multivariate analyses...
Abstract Objective: Primary cilia are evolutionally conserved cell structures involving multiple functions by sensing extracellular signals. Loss of primary is frequently observed in various cancer types, suggesting that the absence this organelle may promote tumorigenesis. However, little known about role oral premalignant lesions and squamous carcinoma (OSCC). Materials Methods: Immunofluosense staining was carried out to detect incidence every stages carcinogenesis from normal OSCC....