A5100383765- Nanoparticle-Based Drug Delivery
- Inflammatory Biomarkers in Disease Prognosis
- Advanced Drug Delivery Systems
- Cancer Immunotherapy and Biomarkers
- Electrospun Nanofibers in Biomedical Applications
- Retinal Diseases and Treatments
- Computational Drug Discovery Methods
- RNA Interference and Gene Delivery
- Inflammatory mediators and NSAID effects
- Cytokine Signaling Pathways and Interactions
- Image Enhancement Techniques
- Corneal Surgery and Treatments
- Osteoarthritis Treatment and Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Tryptophan and brain disorders
- Polymer Surface Interaction Studies
- Bioinformatics and Genomic Networks
- SARS-CoV-2 and COVID-19 Research
- Phagocytosis and Immune Regulation
- Hydrogen Storage and Materials
- HER2/EGFR in Cancer Research
- Retinal and Macular Surgery
- Ammonia Synthesis and Nitrogen Reduction
- Cancer-related molecular mechanisms research
- Gold and Silver Nanoparticles Synthesis and Applications
Meizhou City People's Hospital
2025
Jilin University
2015-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2025
First Affiliated Hospital of Xi'an Jiaotong University
2019-2025
China Medical University
2024-2025
Third Hospital of Hebei Medical University
2022-2025
Hebei Medical University
2022-2025
Harbin Medical University
2021-2025
Chengdu Women's and Children's Central Hospital
2024
Chengdu Medical College
2024
Abstract Background Mutations in KRAS and BRAF genes are prevalent colorectal cancer (CRC), which strikingly promote tumorigenesis lead to poor response a variety of treatments including immunotherapy by activating the MAPK/ERK pathway. Thus, there is an urgent need discover effective therapeutic targets strategies. Methods CRISPR-Cas9 lentiviral knockout library was used screen suppressors anti-PD1 immunotherapy. Bioinformatic analysis analyze correlation between PHF8 expression immune...
Liposome, a widely used drug delivery system (DDS), still shows several disadvantages such as dominant clearance by liver and poor target organ deposition. To overcome the drawbacks of liposomes, we developed novel red blood cell (RBC)-liposome combined DDS to modulate tumor accumulation extend circulation life existing liposomal DDS. Here, RBCs, an ideal natural carrier DDS, were utilized carry liposomes avoid them undergo fast in blood. In this study, could either absorbed onto RBCs'...
The PEGylated AuNPs have an adverse effect on the deformability and oxygen-delivering ability of erythrocytes through damage to cell membrane.
Activated macrophages play a vital role in rheumatoid arthritis (RA) pathophysiology. CD44 is an overexpressed receptor on activated that potential target site for RA treatment. In this study, we prepared hyaluronic acid (HA) coated acid-sensitive polymeric nanoparticles (HAPNPs) composed of egg phosphatidylcholine, polyethylenimine, and poly (cyclohexane-1,4-diyl acetone dimethylene ketal) (PCADK) loaded with dexamethasone (Dex) the treatment RA. PCADK was used to form cores because its...
Age-related macular degeneration is a multifactorial disease involving inflammation and choroidal neovascularization. Vascular endothelial growth factor (VEGF) has been regarded as potential therapeutic target to treat Dexamethasone can interfere with the expression or action of VEGF while bevacizumab targets combines VEGF. We propose electrostatically-conjugated bevacizumab-bearing dexamethasone-loaded poly (D,L-lactide-co-glycolide)/polyethylenimine nanoparticles (eBev-DPPNs) for...
Docetaxel (DTX) is commonly used for breast cancer treatment. Tween 80 DTX dissolution in its clinical formulation causes severe hypersensitivity and other adverse reactions. In this study, trastuzumab (Tmab)-coated lipid-polymer hybrid nanoparticles (PLNs) were prepared, composed of poly (d, l-lactide- co-glycolide), PLGA; polyethylenimine (PEI); lipids. The PLGA/PEI/lipid formed a hydrophobic core, while Tmab was electrostatically adsorbed on the surface PLNs as ligand that targets human...
Bevacizumab, a vascular endothelial growth factor (VEGF)-targeting drug, is widely used as an off-label therapeutic for age-related macular degeneration (AMD). To reduce the monthly administration frequency, this study investigated microspheres comprising poly(d, l-lactide-co-glycolide)/poly(cyclohexane-1,4-diyl acetone dimethylene ketal) (PLGA/PCADK) blend that could be loaded with bevacizumab-dextran particles using solid-in-oil-in-water (S/O/W) emulsification. Control were also prepared...
Pulmonary fibrosis (PF) is a progressive interstitial disease characterized by extracellular matrix deposition and destruction of lung tissue structure. Emodin (Emo) natural active compound with anti-inflammatory antioxidant properties. It can prevent damage to alveolar epithelial cells reducing oxidative stress blocking the initiation PF, thereby caused ultimately achieving therapeutic purpose for PF. However, Emo featured low water solubility, rapid metabolic rate oral bioavailability,...
Immune checkpoint blockade therapies fail to induce immune response in the vast majority of cancer patients, so developing robust adjuvants for increasing tumor is central effective immunotherapy. The Wnt/β-catenin pathway a crucial oncogenic signal relation evasion; however, none Wnt inhibitor under clinical or preclinical phases has demonstrated satisfactory specificity. Thus, new compounds modalities that specifically modulate will be great significance and value Herein, inspired by...
Paclitaxel is widely used as a first-line chemotherapy agent to treat malignant tumors. However, paclitaxel causes peripheral nerve fiber damage and neuropathic pain in some patients. In addition, patients received are often accompanied by negative emotions such anxiety. The amygdala critically involved regulating signals, well purpose of this study clarify the role Ca2+/calmodulin-dependent protein kinase II (CaMKII)-positive glutamatergic neurons paclitaxel-induced affective symptoms....
Thyroid carcinoma (THCA) is the most common cancer of endocrine system. Natural killer (NK) cell play an important role in tumor immune surveillance. The aim this study was to explore possible molecular mechanisms involved NK THCA help management and treatment disease. All data were downloaded from public databases. Candidate hub genes associated with identified by limma, WGCNA singleR packages. Functional enrichment analysis performed on candidate genes. Hub Pearson correlation analysis....
Abstract Background Paclitaxel (PTX) chemotherapy frequently induces cognitive impairment, which is closely associated with two key pathological processes: necroptosis of hippocampal neurons and microglial polarization. Necroptotic release damage-associated molecular patterns, triggering inflammatory responses. As the primary immune cells in central nervous system, microglia can exhibit either pro-inflammatory or anti-inflammatory activity depending on their polarization state. However,...
Since the survival of lymphoma patients who experience disease progression or relapse remains very poor, new therapeutic approaches and effective drugs are urgently needed. Here we show that auranofin (AF), an anti-rheumatoid drug thought to inhibit thioredoxin reductases (TXNRDs) as its mechanism action, exhibited potent activity against multiple cancer types, especially B cell lymphoma. Surprisingly, a knockdown TXNRD1 TXNRD2 did not cause significant cytotoxicity, suggesting abrogation...
Aim: To investigate diagnostic value of preoperative inflammatory biomarkers in pancreatic cancer (PCC). Materials & methods: Preoperative circulating Alb/Fib ratio, neutrophil/lymphocyte ratio (NLR), derived NLR (dNLR), platelet/lymphocyte and lymphocyte/monocyte were detected calculated 226 PCC individuals, 232 healthy controls 142 additional controls. Receiver-operating characteristic curve area under the (AUC) used to evaluate efficacy PCC. Results: Combined dNLR Alb could effectively...
The gold nanoparticles (AuNPs) have been widely used as drug delivery systems at several biomedical fields. However, the effect of AuNPs on components human blood is not well characterized. firstly interacted with when using carries. Therefore, it urgent to investigate (including ligands AuNPs) blood, especially its components. In this study, we investigated possible effects polyethylene glycol-coated (PEG@AuNPs) and citric acid-coated (CT-AuNPs) cell function distribution those in including...