A5111064619- Parkinson's Disease Mechanisms and Treatments
- Nerve injury and regeneration
- Pain Mechanisms and Treatments
- Hereditary Neurological Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Neurological diseases and metabolism
- Alzheimer's disease research and treatments
- Genetic Neurodegenerative Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Lysosomal Storage Disorders Research
- Inflammatory mediators and NSAID effects
- Histone Deacetylase Inhibitors Research
- Immune cells in cancer
- Immune Cell Function and Interaction
- Axon Guidance and Neuronal Signaling
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Neurosurgical Procedures and Complications
- Neurological Disorders and Treatments
- CAR-T cell therapy research
- Neurological Disease Mechanisms and Treatments
Fujian Medical University
2025
Shanghai Jiao Tong University
2012-2024
University of Chinese Academy of Sciences
2024
Wuhan University
2021-2024
Sichuan University
2024
West China Hospital of Sichuan University
2024
Shanghai Chest Hospital
2023-2024
Shanghai Institute of Nutrition and Health
2024
Southern Medical University
2018-2023
Zhujiang Hospital
2018-2023
Neuroinflammation and mitochondrial impairment play important roles in the neuropathogenesis of Parkinson's disease (PD). The activation NLRP3 inflammasome accumulation α-synuclein (α-Syn) are strictly correlated to neuroinflammation. Therefore, regulation α-Syn aggregation might have therapeutic potential. It has been indicated that Dl-3-n-butylphthalide (NBP) produces neuroprotection against some neurological diseases such as ischemic stroke. We here intended explore whether NBP suppressed...
Increasing evidence has shown that gut dysbacteriosis may play a crucial role in neuroinflammation Parkinson's disease (PD). However, the specific mechanisms link microbiota to PD remain unexplored. Given critical roles of blood-brain barrier (BBB) dysfunction and mitochondrial development PD, we aimed evaluate interactions among microbiota, BBB, resistance oxidation inflammation PD. We investigated effects fecal transplantation (FMT) on physiopathology...
Abstract Recent studies have demonstrated that hyperphosphorylation of tau protein plays a role in neuronal toxicities α-synuclein (ASYN) neurodegenerative disease such as familial Alzheimer’s (AD), dementia with Lewy bodies (DLB) and Parkinson’s disease. Using transgenic mouse model (PD) expresses GFP-ASYN driven by the PDGF-β promoter, we investigated how accumulation ASYN impacted axonal function. We found retrograde trafficking brain-derived neurotrophic factor (BDNF) DIV7 cultures E18...
Abstract Background In Alzheimer’s Disease (AD), about one-third of the risk genes identified by GWAS encode proteins that function predominantly in endocytic pathways. Among them, Ras and Rab Interactor 3(RIN3) is a guanine nucleotide exchange factor (GEF) for Rab5 small GTPase family has been implicated to be both late onset AD (LOAD) sporadic early (sEOAD). However, how RIN3 linked pathogenesis currently undefined. Methods Quantitative PCR immunoblotting were used measure expression level...
Aim: Oxidative stress and inflammation play critical roles in the neuropathogenesis of PD. We aimed to evaluate oxidative status by measuring serum superoxide dismutase (SOD) with lipoprotein cholesterol high-sensitivity C-reactive protein (hsCRP) respectively PD patients, explore their correlation disease severity. Methods: performed a cross-sectional study that included 204 patients age-matched healthy controls (HCs). Plasma levels SOD, hsCRP, total cholesterol, high-density (HDL-C)...
There are limited data on vascular, inflammatory, metabolic risk factors of dementia in Parkinson's disease (PD) with type 2 diabetes mellitus (DM) (PD-DM). In a study 928 subjects comprising 215 PD DM (including 31 PD-DM dementia, PD-DMD), 341 without PDD) and 372 35 DMD) patients, we investigated if metabolic, magnetic resonance imaging (MRI) markers were associated PD-DM. Lower fasting blood glucose (FBG<5mmol/L, OR=4.380; 95%CI: 1.748-10.975; p=0.002), higher homocysteine (HCY>15μmol/L,...
Abstract Fulminant hepatic failure (FHF) is a potentially fatal liver disease that associated with intrahepatic infiltration of inflammatory cells. As the receptor polyunsaturated long chain fatty acids, GPR120 can regulate cell differentiation, proliferation, metabolism, and immune response. However, whether involved in FHF remains unknown. Using Propionibacterium acnes ( P. )-primed, LPS-induced mice, we found interference activity using pharmacological agonist attenuated severity injury...
Abstract Background Non-small cell lung cancer (NSCLC) is one of the predominant malignancies globally. Percutaneous thermal ablation (PTA) has gained widespread use among NSCLC patients, with potential to elicit immune responses but limited therapeutic efficacies for advanced-stage disease. T-helper type 9 (Th9) cells are a subset CD4 + effector T robust and persistent anti-tumor effects. This study proposes develop PTA-Th9 integrated therapy as strategy treatment. Methods The were measured...
Nerve growth factor (NGF) exerts multiple functions on target neurons throughout development. The recent discovery of a point mutation leading to change from arginine tryptophan at residue 100 in the mature NGFβ sequence (NGF R100W ) patients with hereditary sensory and autonomic neuropathy type V (HSAN V) made it possible distinguish signaling mechanisms that lead two functionally different outcomes NGF: trophic versus nociceptive. We performed extensive biochemical, cellular, live-imaging...
Background and Purpose: Thromboxane A2 (TXA2) receptors (TP) interact with the ligand TXA2 to induce platelet aggregation regulate hemostasis. Recently TP-mediated signaling has been suggested function in multiple cell types brain. In this report, we aim study expression physiological role of TP microglia, particular after brain ischemia. Methods: Ischemic sections were analyzed for expression. Microglial line primary microglia cultured, or neuronal co-culture system was used determine...
Rationale: Resistance to pemetrexed (PEM)-based chemotherapy is a major cause of progression in non-small cell lung cancer (NSCLC) patients. The deubiquitinating enzyme UCHL1 was recently found play important roles chemoresistance and tumor progression. However, the potential mechanisms PEM resistance remain unclear. Methods: Bioinformatics analyses immunohistochemistry were used evaluate expression NSCLC specimens. Kaplan-Meier analysis with log-rank test for survival analyses. We...
Abstract Macroautophagy has been implicated in modulating the therapeutic function of mesenchymal stromal cells (MSCs). However, biological chaperone-mediated autophagy (CMA) MSCs remains elusive. Here, we found that CMA was inhibited response to proinflammatory cytokines interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α). In addition, suppression by knocking down CMA-related lysosomal receptor lysosomal-associated membrane protein 2 (LAMP-2A) significantly enhanced immunosuppressive...
Abstract Rab7 GTPase regulates mitochondrial morphology and function. Missense mutation(s) of underlies the pathogenesis Charcot Marie Tooth 2B (CMT2B) peripheral neuropathy. Herein, we investigate how function are impacted by CMT2B associated V162M mutation. In contrast to recent studies using heterologous overexpression systems, our results demonstrate significant fragmentation in both human patient fibroblasts embryonic (MEFs). Primary cultured E18 dorsal root ganglion (DRG) sensory...
Abstract Retinal thickness is related to Parkinson’s disease (PD), but its association with the severity of PD still unclear. We conducted a Mendelian randomized (MR) study explore between retinal and PD. For two-sample MR analysis, summary statistics obtained from genome-wide studies on nerve fiber layer (RNFL) ganglion cell inner plexiform (GCIPL) were employed as exposure, while associated used outcome. The primary approach utilized was inverse variance weighted. To correct for multiple...
To compare the accuracy of formula 1/2ABC with 2/3SH on volume estimation for hypertensive infratentorial hematoma.One hundred and forty-seven CT scans diagnosed as hemorrhage were reviewed. Based shape, hematomas categorized regular or irregular. Multilobular was defined a special shape Hematoma calculated employing computer-assisted volumetric analysis (CAVA), 2/3SH, respectively.The correlation coefficients between (or 2/3SH) CAVA greater than 0.900 in all subgroups. There neither...
Multiple microRNAs exhibit diverse functions to regulate inflammatory and autoimmune diseases. MicroRNA-99a (miR-99a) has been shown be involved in adipose tissue inflammation downregulated the lesions of diseases rheumatoid arthritis systemic lupus erythematosus. In this study, we found that miR-99a was CD4+ T cells from experimental encephalomyelitis (EAE) mice, an animal model multiple sclerosis. Overexpression alleviated EAE development by promoting regulator inhibiting helper type 1...
To study the relationship between nocturnal blood pressure ( BP ) variation and spontaneous intracerebral hemorrhage ICH among Chinese hypertensive patients its clinical significance, authors retrospectively screened 371 with primary hypertension (189 , 182 without in S hanghai analyzed their demographics, information, variability medication. Compared control group, levels of glucose, triglycerides, creatinine were significantly increased along a marked reduction drop P <.05)....
Abstract Fulminant hepatic failure (FHF) is a clinical syndrome characterized by sudden and severe impairment in liver function. However, the precise mechanism of immune dysregulation that significant to FHF pathogenesis remains unclear. Enhancer zeste homolog 2 (EZH2) has been implicated inflammation as regulator cell In this study, we investigated role EZH2 an animal model human induced Propionibacterium acnes ( P. ) lipopolysaccharide (LPS). We demonstrated depletion dendritic cells (DCs)...
Binding of thromboxane A2 (TXA2) to its receptor TXA2R modulates thrombosis/hemostasis and plays a vital role in the pathogenesis cerebral infarction (CI). In this study, we investigated relationship between polymorphisms CI Chinese Han population effect on platelet function by these polymorphisms. Polymerase chain reaction ligase detection (PCR-LDR) was performed 230 patients 143 healthy volunteers examine four single nucleotide (SNPs) human gene (C795T, T924C G1686A exon region, rs768963...