A5101850029- Neonatal and Maternal Infections
- Parkinson's Disease Mechanisms and Treatments
- Infant Nutrition and Health
- Nerve injury and regeneration
- Hereditary Neurological Disorders
- Nuclear Receptors and Signaling
- Pain Mechanisms and Treatments
- Inflammation biomarkers and pathways
- Neonatal Respiratory Health Research
- Chemokine receptors and signaling
- Bacterial Identification and Susceptibility Testing
- Urologic and reproductive health conditions
- Hemophilia Treatment and Research
- Antibiotic Resistance in Bacteria
- Immune Response and Inflammation
- Enterobacteriaceae and Cronobacter Research
- Genital Health and Disease
- Cellular transport and secretion
- Machine Learning in Bioinformatics
- Inflammatory Biomarkers in Disease Prognosis
- Alzheimer's disease research and treatments
- Genetics and Neurodevelopmental Disorders
- Glycosylation and Glycoproteins Research
Wenzhou Medical University
2020-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2020-2025
Shanghai Jiao Tong University
2019-2023
Ruijin Hospital
2018-2023
University of California, San Diego
2018-2023
Nerve growth factor (NGF) exerts multiple functions on target neurons throughout development. The recent discovery of a point mutation leading to change from arginine tryptophan at residue 100 in the mature NGFβ sequence (NGF R100W ) patients with hereditary sensory and autonomic neuropathy type V (HSAN V) made it possible distinguish signaling mechanisms that lead two functionally different outcomes NGF: trophic versus nociceptive. We performed extensive biochemical, cellular, live-imaging...
The main issue of the Klebsiella pneumoniae species complex (KpSC) research in clinical settings is accurate identification and differentiation closely related within this complex. Moreover, emergence spread carbapenem-resistant K. (CRKP) represent a significant public health threat due to limited treatment options high mortality rates. Understanding genetic basis resistance virulence crucial for developing effective infection control strategies. In work, genomic epidemiology antimicrobial...
Objective: Sepsis remains a major cause of neonatal death. To better characterize the inflammatory response during sepsis, we compared differences in serum cytokines and chemokines between full-term neonates with sepsis without infection. Methods: We enrolled 40 26 infection as controls October 2016 June 2018. Forty /chemokines were analyzed using Luminex Bead Immunoassay System. Results: Our results showed that IL-6, IL-8, TNF-α, IL-1β, MIF, CXCL13, CXCL1, CXCL2, CXCL5, CXCL6, CXCL16,...
Mutations or triplication of the alpha synuclein (ASYN) gene contribute to synucleinopathies including Parkinson's disease (PD), Dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Recent evidence suggests that ASYN also plays an important role in amyloid-induced neurotoxicity, although mechanism(s) remains unknown. One hypothesis is accumulation alters endolysosomal pathways impact axonal trafficking processing amyloid precursor protein (APP). To define function for ASYN, we...
Background: Parkinson's disease (PD) is the most common neurodegenerative movement disorder that known to be related neuro-inflammation. Chemokines participate in this process usually through upregulation of expression levels, which are closely polymorphisms their genes. Recent studies have further revealed association between these and risk PD multiple populations, but not Chinese Han population. Methods: The promoter region CCL2 was sequenced 411 patients 422 gender-age matched control...
Low DJ-1 protein level caused by gene mutation leads to autosomal recessive Parkinson's disease (PD) due impaired antioxidative activity. In sporadic PD patients, although mutations were rarely found, lower of was also reported. Dysregulation expression might contribute low level. Since promoter is the most important element initiate expression, whether polymorphisms in result dysregulation thus lead and cause worth exploring. region sequenced a Chinese cohort evaluate possible links between...
Aim: This study aimed to evaluate the clinical values of platelet parameters in patients with digestive tumors. Patients & methods: A total 974 people were classified into three groups: malignant group, tumors; benign and normal group: healthy individuals. Results: Compared groups, group showed significantly increased count (PLT) plateletcrit (PCT) reduced mean volume (MPV) platelet-large cell rate (P-LCR, p < 0.001). Elevated PLT PCT MPV P-LCR indicated poor overall survival Conclusion:...
Abstract Nerve growth factor (NGF) exerts multiple functions on target neurons throughout development. The recent discovery of a point mutation leading to change from arginine tryptophan at residue 100 in the mature NGFβ sequence (NGF R100W ) patients with hereditary sensory and autonomic neuropathy, type V (HSAN V), made it possible distinguish signaling mechanisms that lead two functionally different outcomes NGF: trophic versus nociceptive. We performed extensive biochemical, cellular...
To explore molecular etiology and clinical characteristics of two pedigrees affected with hereditary factor VII(FVII) deficiency.The nine exons flanking sequences the F7 gene probands were amplified by PCR. The amplicons analyzed direct sequencing. Suspected mutations subjected to SWISS-MODEL modeling analysis protein structure change Pymol software conservation amino acids across various species.For proband pedigree 1, prothrombin time (PT), FVII activity (FVII:C) antigen (FVII:Ag) 36.3 s,...
Abstract Background Sepsis remains a major cause of neonatal death, but its underlying pathological mechanisms are poorly understood. Methods To characterize the serum cytokine/chemokine profile in neonates with sepsis, we enrolled 40 full-term sepsis and 19 without infection as controls. Forty cytokines/chemokines were analyzed using Luminex Bead Immunoassay System. Serum IL-17 was measured an enzyme-linked immunosorbent assay. Results Our results showed that IL-6, IL-8, TNF-α, IL-1β, MIF,...
Abstract Sepsis remained a major cause of neonatal death, but the pathologic mechanisms were poorly understood. The objective this study was to characterize serum cytokine/chemokine profile in neonates with sepsis. In study, we enrolled 40 full-term sepsis and 19 without infection as controls. Serum cytokines/chemokines analyzed using Luminex Bead Immunoassay System. IL-17 measured enzyme-linked immune-absorbent assay. Our results showed that IL-6, IL-8, TNF-α, IL-1β, MIF, CXCL13, CXCL1,...
Abstract Objectives: Sepsis remains a major cause of neonatal death. In order to better characterize the inflammatory response during sepsis, we compared differences in cytokines and chemokines between children with sepsis full-term neonates without infection. Methods: We enrolled 40 26 infection as controls October 2016 June 2018. Forty /chemokines serum were analyzed using Luminex Bead Immunoassay System. Results: Our results showed that IL-6, IL-8, TNF-α, IL-1β, MIF, CXCL13, CXCL1, CXCL2,...