A5046150215- Gastric Cancer Management and Outcomes
- Tracheal and airway disorders
- Gastrointestinal Tumor Research and Treatment
- Airway Management and Intubation Techniques
- Thyroid and Parathyroid Surgery
- Intestinal and Peritoneal Adhesions
- Caveolin-1 and cellular processes
- Cleft Lip and Palate Research
- Mechanisms of cancer metastasis
- Cancer, Lipids, and Metabolism
- Glycosylation and Glycoproteins Research
- Reconstructive Facial Surgery Techniques
- Toxin Mechanisms and Immunotoxins
- Chronic Lymphocytic Leukemia Research
- Sarcoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Salivary Gland Tumors Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- Cancer Research and Treatments
- Hydrogen's biological and therapeutic effects
- Metastasis and carcinoma case studies
- Oral and Maxillofacial Pathology
- Head and Neck Surgical Oncology
- Craniofacial Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
Shanghai Ninth People's Hospital
2017-2024
Shanghai Jiao Tong University
2013-2024
Ruijin Hospital
2024
Zhejiang University
2024
Renji Hospital
2020-2021
University of Rochester Medical Center
2016
N-myc downstream-regulated gene 1 (NDRG1) has been reported to act as a key regulatory molecule in tumor progression-related signaling pathways, especially metastasis. However, the related mechanism not fully discovered yet. Herein we demonstrated that novel of cell migration and invasion, caveolin-1, direct interaction with NDRG1 human colorectal cancer (CRC) cells. Moreover, reduces caveolin-1 protein expression through promoting its ubiquitylation subsequent degradation via proteasome CRC...
It is well established that hypoxia contributes to tumor progression in a inducible factor-2α (HIF-2α)-dependent manner renal cell carcinoma (RCC), yet the role of long noncoding RNAs (LncRNAs) involved hypoxia-mediated RCC remains unclear. Here we demonstrate LncRNA-SARCC (Suppressing Androgen Receptor Renal Cell Carcinoma) differentially regulated by von Hippel-Lindau (VHL)-dependent both culture and clinical specimens. can suppress hypoxic cycle VHL-mutant cells while derepress it...
The diagnosis and treatment of gastrointestinal stromal tumor (GIST) is getting more standardized. In the last two decades, due to elucidation molecular mechanism tumorigenesis, as well effectiveness tyrosine kinase inhibitors, GIST has become well-known one most classical models targeted therapy on solid tumors in precision medicine era. National Comprehensive Cancer Network (NCCN) issued latest version clinical practice guideline soft tissue sarcoma February 2020. Compared with previous...
<title>Abstract</title> <bold>Background:</bold> The ultrasonic scalpel is widely used during surgery. It safe and effective to close the pulmonary artery branch vessels of 7 mm or below with an energy device as reported. However, there have been no multicenter randomized clinical trial assess safety effectiveness using coagulate 5-7mm blood in thoracic <bold>Methods:</bold> This a prospective, multicenter, randomized, parallel controlled, non-inferiority trial. A total 144 eligible patients...
Abstract Background The ultrasonic scalpel is widely used during surgery. It safe and effective to close the pulmonary artery branch vessels of 7 mm or below with an energy device as reported. However, there have been no multicenter randomized clinical trial assess safety effectiveness using coagulate 5–7 blood in thoracic Methods This a prospective, multicenter, randomized, parallel controlled, non-inferiority trial. A total 144 eligible patients planning undergo lung esophageal surgery...
Abstract Peritoneal adhesions (PAs) represent a significant clinical challenge, primarily arising from excessive post‐surgical inflammation, which leads to the deposition of fibrin and extracellular matrix, forming adhesive bands that can cause severe complications such as intestinal obstruction infertility. Current therapeutic options offer limited efficacy in preventing or treating PAs, highlighting need for new strategies. To address this issue, magnesium hydride (MgH₂) microparticles...
Objective: Contrast-enhanced CT is an important method of preoperative diagnosis and evaluation for the malignant potential gastric submucosal tumor (SMT). It has a high diagnostic accuracy rate in differentiating gastrointestinal stromal (GIST) with diameter greater than 5 cm from benign SMT. This study aimed to use deep learning algorithms establish model (GISTNet) based on contrast-enhanced evaluate its value distinguishing GIST ≤ other SMT before surgery. Methods: A test was carried out....
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal in gastrointestinal tract. At present, many professional academic groups and associations at home abroad have released guidelines for diagnosis treatment of GIST. In 2020, Stromal Tumor Expert Committee China Society Clinical Oncology (CSCO) issued first CSCO China. same year, NCCN also guideline tumors (first edition 2021) by separating GIST-related content from soft tissue sarcoma. However, there are inconsistencies...
Pediatric patients with Crouzon syndrome have great possibilities in suffering from obstructive sleep apnea (OSA), which is mainly due to midfacial hypoplasia and facial deformities. For most patients, a multi-disciplinary sequential treatment plan necessary make for often has different phenotypes of severity OSA Typical were selected this study illustrate the necessity individualized therapy treating OSA. In study, four children maxillofacial deformities introduced. Detailed information...
Objective: To establish an in vitro organoid model of human salivary gland basal cell adenoma (BCA). Methods: Fresh tumor sample from a 66-year-old female patient diagnosed with BCA was collected the Dpartment Oral pathology, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School Medicine October 2021. And culture performed medium based on solid droplets matrix gel, and growth observed by inverted microscopy. After 14 days, fixed 10% neutral formalin made into paraffin...