Abstract Background Inflammation is a potential crucial factor in the pathogenesis of subarachnoid hemorrhage (SAH). Circulating microRNAs (miRNAs) are involved regulation diverse aspects neuronal dysfunction. The therapeutic miRNAs has been demonstrated several CNS disorders and thought to involve modulation neuroinflammation. Here, we found that peripherally injected modified exosomes (Exos) delivered brains mice with SAH mechanism was regulated by Methods Next-generation sequencing (NGS)...

Mounting evidence has suggested that modulating microglia polarization from pro-inflammatory M1 phenotype to anti-inflammatory M2 state might be a potential therapeutic approach in the treatment of subarachnoid hemorrhage (SAH) injury. Our previous study indicated sirtuin 1 (SIRT1) could ameliorate early brain injury (EBI) SAH by reducing oxidative damage and neuroinflammation. However, effects SIRT1 on microglial underlying molecular mechanisms after have not been fully illustrated. In...

Acyl-CoA synthetase long chain family member 4 (ACSL4) is closely related to tumor genesis and development in certain tissues. However, the function of ACSL4 early brain injury (EBI) caused by subarachnoid hemorrhage (SAH) unclear. In this study, we investigated expression patterns role SAH post-SAH EBI using a rat model SAH.The was induced autologous blood injection into prechiasmatic cistern rats. We also used two specific inhibitors ferroptosis (Ferrostatin-1 Liproxstatin-1) investigate...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Zhang S, Lai N, Liao K, Sun J, Lin Y. MicroRNA-210 regulates cell proliferation and apoptosis by targeting regulator of differentiation 1 in glioblastoma cells. Folia Neuropathologica. 2015;53(3):236-244. doi:10.5114/fn.2015.54424. APA Zhang, S., Lai, N., Liao, K., Sun, J., & Lin, (2015). Neuropathologica, 53(3), 236-244. https://doi.org/10.5114/fn.2015.54424 Chicago Shuai, Niansheng Keman Jun Yuchang Lin....

Purpose: This study primarily aims to elucidate the underlying mechanism of Tenascin-C in neuroinflammation and microglia polarization a mouse model subarachnoid hemorrhage (SAH). Methods: The was constructed by injecting blood into anterior chiasmatic cistern stimulating primary with hemoglobin vitro. Then, Imatinib mesylate used inhibit Tenascin-C. Through neurological function scoring, brain edema, cell extraction, immunofluorescence staining, CCK8, Tunel Elisa, Western blot other...

miRNAs are important regulators of translation and have been associated with the pathogenesis a number cardiovascular diseases including stroke may be possible prognostic biomarkers. The purpose present study was to determine expression levels in sera subarachnoid haemorrhage (SAH) patients evaluate their relationships severity clinical outcome SAH. Serum samples on day 3 after onset SAH were subjected microarray analysis Exqion miRCURYTM LNA array quantitative PCR analysis. from (n=60)...

The diagnosis and clinical management of aneurysmal subarachnoid hemorrhage (aSAH) is currently limited by the lack accessible molecular biomarkers that reflect pathophysiology disease. We used microRNAs (miRNAs) as diagnostics to characterize plasma extracellular vesicles in aSAH. It unclear whether they can diagnose manage Next-generation sequencing (NGS) was detect miRNA profile (exosomes) three patients with SAH healthy controls (HCs). identified four differentially expressed miRNAs...

Objective: MiRNAs are important regulators of translation and have been described as biomarkers a number cardiovascular diseases, including stroke. The purpose the study was to determine expression levels serum miR-1297 in patients with aneurysmal subarachnoid hemorrhage (aSAH), assess whether prognostic indicator aSAH. Methods: We treated 128 aSAH endovascular coiling. World Federation Neurological Surgeons (WFNS) grades, Hunt-Hess modified Fisher scores were used severity. Neurologic...

Objective: The aim of this study was to evaluate the safety and efficacy endovascular treatment for ruptured very small (≤3 mm) intracranial aneurysms (VSIAs). Methods: clinical data imaging results 152 patients with VSIAs treated coil embolization from August 2014 June 2020 were retrospectively reviewed. influential factors related preoperative complications, aneurysm recurrence, outcomes these analyzed. Results: Among VSIAs, 90 alone, while 62 stent-assisted embolization. Eighteen...

Objective: To investigate the hemodynamic features before and after embolization of paraclinoidal aneurysms using numerical simulation influence on recurrence embolization. Methods: From January 2016 to December 2017, we enrolled a total 113 treated with They were divided into recurrent group stable depending follow-up results. An aneurysm model was generated based 3D-DSA The characteristics analyzed between two groups Computational fluid dynamic (CFD). Results: In group, peak systolic WSS,...

Objective: Posterior communicating artery bifurcation aneurysms (PcomA-BAs) and infundibular dilations (PcomA-IDs) are found at the junction between internal carotid (ICA) posterior (PcomA). Several studies that PcomA-IDs potentially progress to can even rupture. In our clinical practice, digital subtraction angiography (DSA) helps differentiate from unruptured PcomA-BAs. However, when >3 mm in diameter or PcomA absent on DSA, it is challenging use DSA Hemodynamic morphological factors...

Hemodynamic factors are thought to play important roles in the pathogenesis, progression, and rupture of cerebral aneurysms. Previous hemodynamic studies have been based on comparisons between post-ruptured unruptured Nevertheless, changes aneurysm morphology after render these results unreliable. Moreover, pressure, age, gender, parent artery also influence results. Therefore, present study, we identified morphological characteristics aneurysms prior using twelve mirror aneurysms.From our...

The optimal treatment modalities of ruptured middle cerebral artery aneurysm are still controversial. objective this study is to analyze the outcomes patients with aneurysms treated by endovascular coiling.From October 2011 2015, 67 71 received coiling in our hospital. We retrospectively reviewed clinical, radiologic records and outcomes.Of all (67 patients), 42 were coil embolization merely, 27 stent-assisted 2 unruptured bilateral without receiving treatment. Complete occlusion was...

Aneurysmal subarachnoid hemorrhage (aSAH) is a severe form of stroke characterized by high rates mortality and disability. Identifying circulating biomarkers helpful to improve outcomes. In this study, for the first time, we identify interleukin-6 (IL-6) in cerebrospinal fluid (CSF) small extracellular vesicles (sEVs) as potential prognosis aSAH.

Enterprise stent has been widespread used in wide-necked intracranial aneurysms and good efficacy achieved, but there are few reports on its applications very small ruptured literatures. This study aimed to evaluate the safety of stent-assisted coiling embolization aneurysms. We retrospectively reviewed clinical imaging data from 37 patients with who had SAC using stents performed February 2012 July 2016 our department. Data collected analyzed included patient demographics, morphologic...

The microRNA, miR-210, is frequently associated with hypoxia induction, and an increase in its levels often correlated poor prognosis many solid tumours. present study examines the of miR-210 glioma tumours multiple origins to determine if association can be established disease progression.Tissue samples were acquired from normal brain tissue, oligodendroglial astrocytic further divided by grade: diffuse astrocytomas (WHO grade II), anaplastic III), glioblastoma IV). expression was examined...

Background Neuroinflammation participates in the pathogenesis of subarachnoid haemorrhage (SAH); however, no effective treatments exist. MicroRNAs regulate several aspects neuronal dysfunction. In a previous study, we found that exosomal miR-486-3p is involved pathophysiology SAH. Targeted delivery without blood-brain barrier (BBB) restriction to alleviate SAH promising neuroinflammation approach. Methods this modified exosomes (Exo) form an RVG-miR-486-3p-Exo (Exo/miR) achieve targeted...