A5115588106- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Quantum Chromodynamics and Particle Interactions
- Mesenchymal stem cell research
- Particle Detector Development and Performance
- Neurogenesis and neuroplasticity mechanisms
- Bone and Joint Diseases
- Spinal Cord Injury Research
- Glioma Diagnosis and Treatment
- Neutrino Physics Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Visual perception and processing mechanisms
- Neurological Disease Mechanisms and Treatments
- Ophthalmology and Eye Disorders
- Nerve injury and regeneration
- Prostate Cancer Treatment and Research
- Cassava research and cyanide
- Chemical Synthesis and Analysis
- Advanced Synthetic Organic Chemistry
- Phytase and its Applications
- Medical Imaging Techniques and Applications
- Topic Modeling
- Extracellular vesicles in disease
- Software System Performance and Reliability
- Clinical Reasoning and Diagnostic Skills
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2025
Peking Union Medical College Hospital
2010-2025
Tianjin Medical University
2025
Tianjin University
2025
Sun Yat-sen University
2024
Central South University
2024
Chinese University of Hong Kong, Shenzhen
2024
University of Bristol
2020-2022
Argonne National Laboratory
2019-2020
University of Science and Technology of China
2020
Transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) is a potential therapy for cerebral ischemia. Although BMSCs-induced angiogenesis considered important neurological functional recovery, the neurorestorative mechanisms are not fully understood. We examined whether enhances tissue perfusion and creates suitable microenvironment within ischemic brain, which in turn accelerates endogenous neurogenesis leads to improved recovery. Adult female rats subjected 2 h middle artery...
Ischemic stroke is a significant global health crisis, frequently resulting in disability or death, with limited therapeutic interventions available. Although various intrinsic reparative processes are initiated within the ischemic brain, these mechanisms often insufficient to restore neuronal functionality. This has led intensive investigation into use of exogenous stem cells as potential option. comprehensive review outlines ontogeny and activation endogenous neural adult brain following...
Abstract The measurement of cosmic rays at energies exceeding 100 TeV per nucleon is crucial for enhancing the understanding high-energy particle propagation and acceleration models in Galaxy. HERD a space-borne calorimetric experiment that aims to extend current direct measurements unexplored energies, such as protons one PeV. payload scheduled be installed on Chinese Space Station 2027. primary peculiarity instrument its capability measure particles coming from all directions, with main...
Prior knowledge shapes how we interpret and adapt to a dynamic environment. A crucial aspect of this process is the lifelong development structured object representations, enabling meaningful survival-relevant interactions with external world. In study, investigated extent which memories complex objects influence perception by refining visual details. To test this, had participants hold in working memory Mooney images, stimulus class that requires top-down processing perceive hidden image...
Cultured neural networks in vitro have demonstrated the biocomputing capability to recognize patterns. However, underlying mechanisms behind information processing and pattern recognition remain less understood. Here, we developed an network integrated with microelectrode arrays (MEAs) explore network’s classification elucidate this classification. After applying different stimulation patterns using MEAs, exhibited structural alterations distinct electrical responses that recognized various...
This study evaluated the efficacy of human mesenchymal stem cells (hMSCs) in treatment intracerebral hematoma (ICH) using a primate model and serial <sup>18</sup>F-FDG PET scans. <b>Methods:</b> Twenty-four <i>Macaca fascicularis</i> monkeys (male, 4.2 ± 0.2 kg) were enrolled. The ICH models established stereo-guided injection 1.5 mL autologous arterial blood between right cortex basal ganglia. One week (early group, <i>n</i> = 8) or 4 wk (late after an was established, (1–5) ×10<sup>6</sup>...
This study compared the clinical efficacies, advantages and disadvantages of two transplantation approaches for treating spinal cord injury: open surgical exploration combined with local stem cell (referred to as transplantation) by CT-guided puncture transplantation). The patients were divided into following three groups perform a retrospective controlled study: Group A included nine who underwent transplantation, B C did not receive transplantation. Abbreviated Injury Scale (AIS), American...
Transplanted mesenchymal stem cells migrate toward brain lesions and differentiate into neurons, glial cells, neural in diseased or injured animal models. The migratory routes differentiation patterns of normal rats are, however, unknown. Here, labelled human (or saline) were transplanted the striatum adult to observe their migration differentiation.Labelled right adults (n = 24). Brain sections examined for by immunohistochemistry method, fluorescence microscope laser scanning confocal...
Spatial time series imputation is of great importance to various real-world applications. As the state-of-the-art generative models, diffusion models (e.g. CSDI) have outperformed statistical and autoregressive based in imputation. However, may introduce unstable noise owing inherent uncertainty sampling, leading generated deviating from intended Gaussian distribution. Consequently, imputed data deviate real data. To this end, we propose a Self-adaptive Scaling Diffusion Model named SaSDim...
Cyber-Physical Systems (CPSs) are increasingly prevalent across various industrial and daily-life domains, with applications ranging from robotic operations to autonomous driving. With recent advancements in artificial intelligence (AI), learning-based components, especially AI controllers, have become essential enhancing the functionality efficiency of CPSs. However, lack interpretability these controllers presents challenges safety quality assurance AI-enabled CPSs (AI-CPSs). Existing...
The efficacy of stem cell transplantation for promoting recovery patients with neurological diseases, such as stroke, has been reported in several studies. However, the safety intracerebral human mesenchymal cells (hMSCs) remains unclear. aim study was to evaluate hMSCs transplanted cerebrum Macaca fascicularis and provide evidence clinical application. A total 24 M were assigned 3 groups randomly: low dose (3.0 × 10 5 cells/kg), high (2.5 6 control (normal saline [NS]). Human or NS injected...
The measurement of cosmic rays at energies exceeding 100 TeV per nucleon is crucial for enhancing the understanding high-energy particle propagation and acceleration models in Galaxy. HERD a space-borne calorimetric experiment that aims to extend current direct measurements unexplored energies. payload scheduled be installed on Chinese Space Station 2027. primary peculiarity instrument its capability measure particles coming from all directions, with main detector being deep, homogeneous, 3D...
Motivation: Basic type of intermittent exotropia (IXT) is one the most common strabismus subtypes in children and adolescents, yet a clear consensus its etiology treatment approach still lacking. Goal(s): To discover abnormal brain cortical structures related to this disease explore central nervous system mechanisms IXT. Approach: IXT patients healthy volunteers were recruited, extracted from their whole-brain MRI morphological data compared using SBM method. Results: Distinct differences...
Motivation: To better understand the pathophysiological progression mechanism of childhood basic-type IXT and develop an accurate approach for early diagnosis. Goal(s): find a valuable tool in reflecting pathological changes visual center pathway children. Approach: A voxel-wise analysis was performed MAPMRI-derived parameters between patients health controls, DTI used as reference.Results: Compared with DTI, demonstrated significant differences more brain regions associated cortex. Brain...
Wheat flour is a major dietary source of iron; however, during milling to produce white wheat flour, the mineral-rich aleurone layer removed. In UK elemental iron added replace lost processing (1) . Soy also bread as improver (2) Legumes, including soy, are rich in and this raises possibility that legume could be used increase content products (3) The aim study was investigate bioaccessibility from fava bean-fortified test hypothesis beans have potential natural fortificants for flour. Dried...