A5044379017- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- Autoimmune Neurological Disorders and Treatments
- Cerebral Venous Sinus Thrombosis
- Neuroinflammation and Neurodegeneration Mechanisms
- MRI in cancer diagnosis
- Ultrasound and Hyperthermia Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Thyroid Cancer Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Computational Drug Discovery Methods
- Neurological Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Medical Imaging Techniques and Applications
- Venous Thromboembolism Diagnosis and Management
- Cell Adhesion Molecules Research
- Ultrasound Imaging and Elastography
- Photoacoustic and Ultrasonic Imaging
- Pituitary Gland Disorders and Treatments
- IgG4-Related and Inflammatory Diseases
- Advanced Fiber Laser Technologies
- Vestibular and auditory disorders
- Intracranial Aneurysms: Treatment and Complications
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Peking Union Medical College Hospital
2016-2025
Tianjin University of Science and Technology
2025
Quzhou University
2025
Zhejiang University
2025
Shanghai Jiao Tong University
2024
Shanghai University of Medicine and Health Sciences
2018-2024
Pudong New Area People's Hospital
2018-2024
Nanjing University of Science and Technology
2018-2022
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2022
Background: The complications of coronavirus disease 2019 (COVID-19) involved multiple organs or systems, especially in critically ill patients. We aim to investigate the neurological patients with COVID-19. Methods: This retrospective single-center case series analyzed COVID-19 at intensive care unit Tongji Hospital, Wuhan, China from February 5 April 2, 2020. Demographic data, clinical and laboratory findings, comorbidities treatments were collected analyzed. Results: Among 86 confirmed...
Background Dl-3-n-butylphthalide (NBP), first isolated from the seeds of celery, showed efficacy in animal models stroke. This study was a clinical trial to assess and safety NBP with continuous dose regimen among patients acute ischemic Methods A randomized, double-blind, double-dummy enrolled 573 within 48 hours onset stroke China. Patients were randomly assigned receive 14-day infusion followed by an capsule, 14- day aspirin, or ozagrel aspirin. The measures Barthel index score modified...
High-throughput metabolic fingerprinting has been deemed one of the most promising strategies for addressing high false positive rate prostate cancer (PCa) diagnosis in prostate-specific antigen (PSA) gray zone. However, current remains challenging achieving high-precision metabolite detection complex biological samples (e.g., serum and urine). Herein, a novel self-assembly MoS
Autoimmune encephalitis associated with antibodies against γ-aminobutyric acid B receptor (GABA R) in patients limbic (LE) was first described 2010. We present a series of Han Chinese for further clinical refinement.Serum and cerebrospinal fluid (CSF) samples from referred to the program paraneoplastic syndrome Peking Union Medical College Hospital were tested indirect immunofluorescence. Clinical information anti-GABA R antibody positivity retrospectively reviewed, descriptive statistical...
Purpose: Ischemic vascular diseases, including myocardial infarction (MI) and stroke, have been found to be associated with elevated expression of αvβ3-integrin, which provides a promising target for semi-quantitative monitoring the disease.For first time, we employed 68 Ga-S-2-(isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid-PEG3-E[c(RGDyK)]2 ( Ga-PRGD2) evaluate αvβ3-integrin-related repair in post-MI post-stroke patients via positron emission tomography/computed...
Non-Hermitian degeneracies reveal intriguing and non-trivial behaviors in open physical systems. Examples like Parity-Time (PT) symmetry breaking, topological encircling chirality, enhanced sensing near an exceptional point (EP) are often associated with the abrupt nature of phase transition around these degeneracies. Here we experimentally observe a cavity-enhanced second-harmonic frequency (SHG) conversion on PT line, i.e. set consisting open-ended isofrequency or isoloss lines, both...
Photons with zero rest mass are impossible to be stopped. However, a pulse of light can slowed down and even halted through strong light-matter interaction in dispersive medium atomic systems. Exceptional point (EP), non-Hermitian singularity point, introduce an abrupt transition dispersion. Here we experimentally observe room-temperature storing near exceptional induced by nonlinear Brillouin scattering chip-scale 90-μm-radius optical microcavity, the smallest platform up date store light....
BACKGROUND:This study aimed to compare superb microvascular imaging (SMI) with grayscale ultrasound (US) and color Doppler flow (CDFI) evaluate vascular distribution morphology distinguish between benign malignant thyroid nodules. MATERIAL AND METHODS:Seventy-one patients 76 nodules underwent US, CDFI, SMI imaging. CDFI assessed quantity, morphology, distribution, was graded according Adler's method, as absent (grade 0), minimal 1), moderate 2), or marked 3). The detection of malignancy...
BACKGROUND This study explored the diagnostic value of a combined modality Superb Microvascular Imaging (SMI) and shear-wave elastography in differentiating malignant benign breast lesions. MATERIAL AND METHODS A total 121 patients with 123 lesions enrolled underwent conventional ultrasound exam (US), Color Doppler Flow (CDFI), SMI examination, Virtual Touch Tissue Quantification (VTQ) measurement between May 2016 October 2017. Vessels were detected by both CDFI quantitative manner. The...
This study provides an overview of the prognosis intravascular large B cell lymphoma (IVLBCL) over past 10 years and analyzes possible relevant factors.We conducted a literature search case reports, series, retrospective studies IVLBCL published from January 2008 to July 2018. After excluding inappropriate data, 103 publications were selected for analysis. Statistical analyses different treatment modalities, effect blood-brain barrier (BBB)-penetrating drugs, prognostic factors outcomes...
Ultrasound (US) is widely used in the clinical diagnosis of thyroid nodules. Artificial intelligence-powered US becoming an important issue research community. This study aimed to develop improved deep learning model-based algorithm classify benign and malignant nodules (TNs) using images.In total, 592 patients with 600 TNs were included internal training, validation, testing data set; 187 200 recruited for external test set. We developed a Visual Geometry Group (VGG)-16T model, based on...
Abstract Deep convolutional neural networks (DCNNs) have demonstrated promising performance in classifying breast lesions 2D ultrasound (US) images. Exiting approaches typically use pre-trained models based on architectures designed for natural images with transfer learning. Fewer attempts been made to design customized specifically this purpose. This paper presents a comprehensive evaluation learning solutions and automatically networks, analyzing the accuracy robustness of different...
Alzheimer's disease (AD) is a heterogeneously progressive neurodegeneration disorder with varied rates of deterioration, either between subjects or within different stages certain subject. Estimating the course AD at early has treatment implications. We aimed to analyze progression identify distinct patterns in trajectory.We proposed deep learning model underlying trajectory from cognitively normal (CN) state mild cognitive impairment (MCI) dementia, by jointly predicting time-to-conversion...
Ion-conductive gels (ICGs) are essential for achieving human–machine interfaces, bioelectronic applications, or durable wearable sensors. However, traditional solvent-dependent ICGs face bottlenecks such as dehydration-induced failure and challenges in a balance between conductivity mechanical properties. Here, this work developed novel ternary ion-conductive xerogel (PEM-Li ICXG) system based on polyethylene glycol (PEG), poly (2-methoxyethyl acrylate) (PMEA), LiTFSI. PEM-Li ICXGs exhibit...
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a treatable autoimmune neurologic syndrome that occurs with or without tumor association. However, some severe cases are refractory to systemic immunotherapy. This pilot study aimed evaluate the utility and safety of intrathecal methotrexate injection for patients anti-NMDAR who did not respond first-line immunotherapy.Intrathecal injections dexamethasone were performed weekly in four legible within consecutive 4 weeks....
On September 18th, 2024, the Federal Reserve announced a 0.5% reduction in benchmark rates, marking its first cut since April 2020. This study aims to investigate rationale behind this monetary policy decision and evaluate impacts on U.S. economy, particularly context of an ongoing recession. By examining both domestic global economic factors, research identifies decelerating growth mounting inflationary pressures as key drivers shift. The methodology integrates literature review, historical...
Abstract Previous research has established Type 2 Diabetes Mellitus as a significant risk factor for various disorders, adversely impacting human health. While evidence increasingly links type diabetes to cognitive impairment and brain understanding the causal effects of its preclinical stage on health is yet be fully known. This knowledge gap hinders advancements in screening preventing neurological psychiatric diseases. To address this gap, we employed robust machine learning algorithm...
Abstract This comprehensive review synthesizes the latest advancements in understanding inflammatory disorders affecting cerebral small vessels, a distinct yet understudied category within vessel diseases (SVD). Unlike classical SVD, these conditions exhibit unique clinical presentations, imaging patterns, and pathophysiological mechanisms, posing significant diagnostic therapeutic challenges. Highlighting their heterogeneity, this spans primary angiitis of central nervous system, amyloid...
Abstract INTRODUCTION Cerebrovascular lesions are associated with cognitive impairment. However, the impact of AD neuropathological changes (ADNC) on cerebral microvasculature is not completely understood. METHODS Twelve decedents ADNC and 15 matched controls were selected from Brain Bank. The in median tunica basement membrane‐related extracellular matrix (ECM) contents quantified compared. Additionally, we explored related mechanisms agrin pericytes. RESULTS Venular collagenosis was...