A5101984029- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Advanced Neuroimaging Techniques and Applications
- Cerebrovascular and genetic disorders
- Dementia and Cognitive Impairment Research
- Cerebrospinal fluid and hydrocephalus
- Cardiovascular Health and Disease Prevention
- Moyamoya disease diagnosis and treatment
- Fetal and Pediatric Neurological Disorders
- Functional Brain Connectivity Studies
- Cerebral Venous Sinus Thrombosis
- Dialysis and Renal Disease Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Head and Neck Cancer Studies
- Neurological Disease Mechanisms and Treatments
- Metabolomics and Mass Spectrometry Studies
- Obstructive Sleep Apnea Research
- Intracranial Aneurysms: Treatment and Complications
- Health, Environment, Cognitive Aging
- Vascular Malformations Diagnosis and Treatment
- RNA regulation and disease
- Neuroendocrine Tumor Research Advances
- Brucella: diagnosis, epidemiology, treatment
- Neurosurgical Procedures and Complications
Peking Union Medical College Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
China University of Petroleum, East China
2025
Southern University of Science and Technology
2024
China Academy of Chinese Medical Sciences
2023
Shanghai Maritime University
2021
Xinjiang Production and Construction Corps
2016-2019
Thermo Fisher Scientific (Japan)
2017
University of Shanghai for Science and Technology
2017
University of Electronic Science and Technology of China
2008
Background and Purpose Epidemiological data of cerebral small vessel disease (CSVD) in the general population China are lacking. We report on prevalence lacunes, white matter hyperintensity (WMH), microbleeds (CMBs) a community-based sample compare results with those other studies. Methods This was cross-sectional analysis population-based Shunyi Study China. A total 1,211 stroke-free participants (mean age, 55.6±9.3 years; 37.4% men) available 3 Tesla (3T) magnetic resonance images were...
Background: The complications of coronavirus disease 2019 (COVID-19) involved multiple organs or systems, especially in critically ill patients. We aim to investigate the neurological patients with COVID-19. Methods: This retrospective single-center case series analyzed COVID-19 at intensive care unit Tongji Hospital, Wuhan, China from February 5 April 2, 2020. Demographic data, clinical and laboratory findings, comorbidities treatments were collected analyzed. Results: Among 86 confirmed...
Although inflammation has been proposed to be a candidate risk factor for cerebral small vessel disease (CSVD), previous findings remain largely inconclusive and vary according status study designs. The present aimed investigate possible associations between inflammatory biomarkers MRI markers of CSVD.A group 15 serum representing variety those putatively involved in the cascade was grouped assessed cross-sectional involving 960 stroke-free subjects. biomarker panel as follows: systemic...
Background and Purpose— Intracranial arterial dolichoectasia (IADE) is a poorly understood arteriopathy compared with intracranial atherosclerotic stenosis (ICAS). We aimed to investigate the risk factors of IADE ICAS their relationship neuroimaging markers cerebral small vessel disease in population-based study. Methods— This study comprised 1237 participants (aged 57.2±9.4 years, 37.6% men) who underwent brain magnetic resonance imaging angiography. was assessed based on basilar artery...
在可生物降解的骨植入物材料中,锌基合金由于其优异的机械性能和生物相容性,在医用骨植入物领域表现出巨大的潜力。该研究采用熔融方法制备 Zn-xGe (x = 1.5 wt.%, 2.5 3.5 4.5 wt.%) 合金,并研究了其微观结构、机械性能、腐蚀降解行为、细胞毒性和溶血速率。合金表现出致密的结构,包括 α-Zn 和共晶 Ge 相。与纯锌相比,添加一定量的 可改善合金的机械性能。在 Zn-Ge 合金中,与纯 Zn 相比,势垒效应和微电偶效应的综合作用导致腐蚀速率显著降低。所制备的 合金表现出良好的抗菌性能和血液相容性;在提取物的 50%、25% 和 12.5% 浓度下,合金表现出良好的细胞相容性。
Abstract Previous research has established Type 2 Diabetes Mellitus as a significant risk factor for various disorders, adversely impacting human health. While evidence increasingly links type diabetes to cognitive impairment and brain understanding the causal effects of its preclinical stage on health is yet be fully known. This knowledge gap hinders advancements in screening preventing neurological psychiatric diseases. To address this gap, we employed robust machine learning algorithm...
Zinc-based alloys have attracted increasing attention as biodegradable metals by virtue of their excellent mechanical, degradable and biocompatible properties. By introducing different levels manganese (0.1, 0.3, 0.5 0.8 wt%), the properties pure zinc were improved. The obtained zinc-manganese consisted mainly a matrix MnZn13 phase, which led to significant improvement mechanical with ultimate tensile strength (UTS), yield (YS) elongation up 117.3 MPa, 110.4 14%, respectively, Vickers...
Abstract This comprehensive review synthesizes the latest advancements in understanding inflammatory disorders affecting cerebral small vessels, a distinct yet understudied category within vessel diseases (SVD). Unlike classical SVD, these conditions exhibit unique clinical presentations, imaging patterns, and pathophysiological mechanisms, posing significant diagnostic therapeutic challenges. Highlighting their heterogeneity, this spans primary angiitis of central nervous system, amyloid...
Background and objective Studies on relations between arterial stiffness full spectrum of radiological features cerebral small vessel disease (CSVD) are scarce. We aim to investigate the association with lacunes, white matter hyperintensities (WMH), microbleeds (CMBs), dilated perivascular spaces (PVS), brain atrophy in a community-based sample. Methods A total 953 participants (55.7±9.4 years) who underwent brachial-ankle pulse wave velocity (baPWV) magnetic resonance imaging were included....
<h3>Objective</h3> To investigate the association of carotid atherosclerosis, dilation, and stiffness with imaging markers cerebral small vessel disease (CSVD) in a community-based sample. <h3>Methods</h3> The study comprised 1,051 participants (age 57.5 ± 9.2 years). Carotid plaques, intima-media thickness (IMT), diastolic diameter, pulse wave velocity, index (β) were measured by ultrasound. Imaging CSVD, including lacunes, microbleeds, dilated PVS, white matter hyperintensities (WMH)...
Background and purpose This study aimed to investigate the association of metabolic syndrome (MetS) with both intracranial atherosclerotic stenosis (ICAS) imaging markers cerebral small vessel disease (CSVD) in a community-based sample. Methods included 943 participants (aged 55.6±9.2 years, 36.1% male) from Shunyi cohort study. MetS was defined according joint interim criteria quantified by severity Z-score. ICAS evaluated brain magnetic resonance angiography. The MRI CSVD, including white...
Further studies are needed to improve the understanding of pathological process underlying cognitive impairments. The purpose this study is investigate global and topographic changes white matter integrity cortical structure related impairments in a community-based population.A cross-sectional analysis was performed based on 995 subjects (aged 56.8 ± 9.1 years, 34.8% males) from Shunyi study, community-dwelling cohort. Cognitive status accessed by series neurocognitive tests including...
Our aim is to investigate whether vascular risk factors are associated with cerebral deep medullary veins (DMVs) and DMVs MRI markers of small vessel disease (CSVD) or stroke. In a community-based cohort 1056 participants (mean age 55.7 years), were identified on susceptibility-weighted imaging (SWI) counted in periventricular regions. Neuroimaging including lacunes, whiter matter hyperintensity (WMH), microbleeds, enlarged perivascular space, brain atrophy evaluated. The number decreased (p...
Abstract Motor impairment is common in the elderly population. Disrupted white matter tracts and resultant loss of connectivity between cortical regions play an essential role motor control. Using diffusion tensor imaging (DTI), we investigated effect microstructure on upper-extremity lower-extremity function a community-based sample. A total 766 participants (57.3 ± 9.2 years) completed assessment performance, including 3-m walking speed, 5-repeat chair-stand time, 10-repeat hand...
Rapid economic growth and increasing lifespan have contributed to an burden of chronic non-communicable diseases in China. Population-based studies focusing on cardiovascular disease age-related brain changes, with extensive clinical, genetic, imaging data as well a comprehensive evaluation function are lacking The Shunyi cohort study aimed investigate the determinants consequences alterations among individuals residing rural area Beijing.This prospective, community-based included aged 35...
<h3>BACKGROUND AND PURPOSE:</h3> Previous studies have shown that diffusion tensor imaging suggests a diffuse loss of white matter integrity in people with hyperintensities or lacunes. The purpose this study was to investigate whether the presence cerebral microbleeds and their distribution are related microstructures. <h3>MATERIALS METHODS:</h3> comprised 982 participants who underwent brain MR determine microbleed status. cross-sectional relation between microstructural assessed by 2...
Background and Purpose: To compare the risk factors of stroke between lacune large perivascular spaces (PVSs) in a community-based sample. Methods: Large PVSs were assessed using 3.0T MRI population-based cohort consisting 1,204 participants. The relationship cardiovascular factors, neuroimaging changes, incidental presence or was with univariate multivariable ordinal logistic regression analysis. Results: Of study participants (55.7 ± 9.3 years, 37.0% men), total 347 detected 235 (19.5%)...
Our aim is to investigate the association of cerebral deep medullary veins (DMVs) with white matter microstructural integrity and regional brain atrophy in MRI. In a community-based cohort 979 participants (mean age 55.4 years), DMVs were identified on susceptibility-weighted imaging. Brain structural measurements including gray hippocampus volumes, as well diffusion tensor metrics, evaluated. The mean (SD)number was 19.0 (1.7). A fewer number related lower fractional anisotropy higher...