A5100627107- Cardiac Arrhythmias and Treatments
- Pancreatic and Hepatic Oncology Research
- Cardiac pacing and defibrillation studies
- Cancer-related molecular mechanisms research
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Sexual function and dysfunction studies
- Ovarian cancer diagnosis and treatment
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Surgical Treatments
- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- Cardiovascular Function and Risk Factors
- RNA modifications and cancer
- Ion channel regulation and function
- Heart Failure Treatment and Management
- Sexuality, Behavior, and Technology
- Blood Pressure and Hypertension Studies
- Cancer-related Molecular Pathways
- Cardiovascular and exercise physiology
- Hormonal Regulation and Hypertension
- Ferroptosis and cancer prognosis
- Uterine Myomas and Treatments
- Pulmonary Hypertension Research and Treatments
- ECG Monitoring and Analysis
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2025
Peking Union Medical College Hospital
2021-2025
First Hospital of Jilin University
2025
Jilin University
2025
Huazhong University of Science and Technology
2025
Tongji Hospital
2025
KU Leuven
2024
Chinese University of Hong Kong
2024
Second Affiliated Hospital of Dalian Medical University
2024
Peking University Cancer Hospital
2023-2024
To identify the cooperation of authors, countries, institutions and explore hot topics' prospects regarding research prostate diseases erectile dysfunction (ED).Publications on ED were retrieved from Web Science Core Collection (WoSCC). Bibliometric analyses performed using VOSviewer CiteSpace software. Network maps generated to evaluate collaborations between different institutions, keywords.A total 2,599 articles related study identified. We observed gradually increasing in number...
Hepatocellular carcinoma (HCC) is one of the most prevalent and life-threatening malignancies worldwide. There are few diagnostic prognostic biomarkers druggable targets for HCC. Aldehyde dehydrogenase 1 (ALDH1) a marker stem cells in variety cancers, but mRNA levels value ALDH1 isoforms HCC patients remain unknown. In present study, gene ontology annotation family was performed using Database Annotation, Visualization Integrated Discovery (DAVID), pathway analsis GeneMANIA software. The...
The aim of the present study was to identify potential prognostic microRNA (miRNA) biomarkers for hepatocellular carcinoma (HCC) prognosis prediction based on a dataset from Cancer Genome Atlas (TCGA).A miRNA sequencing and corresponding clinical parameters HCC were obtained TCGA. Genome-wide univariate Cox regression analysis used screen differentially expressed miRNAs (DEMs), multivariable signature construction. Comprehensive survival performed evaluate value signature.Five regarded as...
Blood pressure (BP) is a continuous and dynamic measure. However, standard BP control metrics may not reflect the variability in over time.This study assessed prognostic value of time target range among hypertensive patients with heart failure (HF).The authors performed post hoc analysis data from TOPCAT (Treatment Preserved Cardiac Function HF an Aldosterone Antagonist) trial BEST (Beta-Blocker Evaluation Survival Trial). Time (TTR) for each patient was calculated using linear interpolation...
Purpose: Therapeutic options for patients with platinum-resistant ovarian cancer (PROC) remain a major unmet need. PROC multiple recurrences are unable to continue highly toxic treatment after prior lines of systemic therapy. Chemotherapy-free option lenvatinib plus anti-programmed cell death protein-1 (PD-1) combination therapy has shown promising results in several malignancies including cancer, but the toxicity high starting dose is also notable and needs be improved. Our previous pilot...
ABSTRACT Hepatic lipid droplet (LD) accumulation is a hallmark of nonalcoholic fatty liver disease (NAFLD). Although the clinical efficacy berberine (BBR) in treating NAFLD has been established, mechanism remains uncertain. This study to evaluate effects BBR on hepatic LDs and investigate underlying mechanisms. Using high‐fat diet‐induced obese (DIO) mice as model for NAFLD, was administered daily by gavage 4 weeks. Liver tissue examined changes deposition histology. Transcriptomics...
Abstract Cytochrome P2C ( CYP 2C) subfamily members 2C8 , 2C9 2C18 and 2C19 ) are known to participate in clinical drug metabolism. However, the association between 2C hepatocellular carcinoma HCC remains unclear. This study investigated prognostic value of gene expression levels with prognosis. Data 360 patients The Cancer Genome Atlas database 231 Gene Expression Omnibus were analyzed. Kaplan–Meier analysis a Cox regression model used ascertain overall survival recurrence‐free survival,...
Background/Aims: The aim of the current study was to identify potential prognostic long non-coding RNA (lncRNA) biomarkers for predicting survival in patients with hepatocellular carcinoma (HCC) using Cancer Genome Atlas (TCGA) dataset and bioinformatics analysis. Methods: sequencing clinical data HCC from TCGA were used association assessment by univariate Cox A signature built stepwise multivariable analysis, a comprehensive analysis performed evaluate its value. further evaluated...
Objective: The activities of four cytochrome P3A (CYP3A) subfamily members (CYP3A4, CYP3A5, CYP3A7, and CYP3A43) are well documented in drug metabolism. However, the association between CYP3A hepatocellular carcinoma (HCC) remains unclear. This study investigated prognostic value mRNA expression levels with HCC prognosis. Materials methods: Data from a total 360 patients were retrieved Cancer Genome Atlas database, data 231 Gene Expression Omnibus database. Kaplan–Meier analysis Cox...
Cardiac magnetic resonance imaging analysis has been a useful tool in screening patients for heart disease. Early, timely and accurate diagnosis of diseases the series is key to effective treatment. MRI provides important material cardiac diseases. The rise deep learning transformed computer-aided diagnostic systems, especially field medical imaging. Existing work on structure segmentation models based mainly relies convolutional neural networks (CNNs), which lack model diversity limit...
Objective: The goal of our study is to identify a competing endogenous RNA (ceRNA) network using dysregulated RNAs between HCC tumors and the adjacent normal liver tissues from Cancer Genome Atlas (TCGA) datasets, investigate underlying prognostic indicators in hepatocellular carcinoma (HCC) patients. Methods: All RNA- miRNA-sequencing datasets were obtained TCGA, investigated by DESeq edgeR algorithm. Survival analysis was used confirm indicators. Results: In present study, we constructed...
Dilated cardiomyopathy (DCM) is a complex type of that affected by both genetic and non-genetic factors. It characterized an enlargement the left ventricle or bi-ventricle, often accompanied cardiac systolic dysfunction. The main results include arrhythmia, heart failure (HF), sudden death. prognosis this disease usually poor, 5-year survival time about 50%. Early diagnosis very important for treatment DCM. Studies have shown primary prevention after discovering effectively reduces mortality...
Pulmonary benign metastasizing leiomyoma (PBML) is the most common extrauterine spread of uterine leiomyoma, and its biological behavior traditionally thought to be hormone dependent. Studies on older PBML patients have been previously reported, but limited literature has published regarding clinical features treatment in young women.A total 65 cases women aged 45 years younger were reviewed, including 56 selected from PubMed 9 our hospital. The characteristics management these analyzed.The...
We aimed to investigate the differences of transcriptome profile between 2 groups high-grade serous ovarian cancer (HGSOC) patients with distinct outcomes and identify potential biomarkers for recurrence.RNA sequencing was performed in HGSOC similar demographic characteristics but exhibiting progression-free survival (PFS). Transcriptome data poor response (PR; PFS ≤6 months) good (GR; ≥12 group were compared. employed xCell evaluate abundance 63 cells tumor microenvironment. The predictive...
Treatment options for heavily pre-treated recurrent ovarian and endometrial cancer are limited. Lenvatinib plus anti-programmed cell death protein-1 (PD-1) combination therapy has been efficacious in advanced cancer, but at the recommended dose level, high-grade adverse events occur lead to drug discontinuation. This study evaluated feasibility of low-dose lenvatinib anti-PD-1 patients with cancer.
Abstract Aims Predicting the risk of malignant arrhythmias (MA) in hospitalized patients with heart failure (HF) is challenging. Machine learning (ML) can handle a large volume complex data more effectively than traditional statistical methods. This study explored feasibility ML methods for predicting MA HF patients. Methods and results We evaluated baseline events 2794 cohort Anhui Province randomly divided population into training validation sets 7:3 ratio. The Lasso‐logistic regression,...
The effect of micronutrients on urologic cancers has been explored in observational studies. We conducted the two-sample mendelian randomization (TSMR) study to investigate whether could causally influence risk cancers.Summary statistics for four and three main outcomes were obtained from genome-wide association studies (GWAS). MR analyses applied explore potential causal between them. Sensitivity using multiple methods also conducted.Genetically predicted one SD increase serum copper iron...
Aldehyde dehydrogenase 1 family member L1 (ALDH1L1) is downregulated in hepatocellular carcinoma (HCC) tumors, and its decreased expression associated with the poor prognosis of HCC patients. We, therefore, evaluated effect single nucleotide polymorphisms (SNPs) ALDH1L1, mRNA on survival hepatitis B virus (HBV)‑related patients association tumor protein p53 (TP53) expression. ALDH1L1 SNPs 415 HBV-related were genotyped via direct sequencing. Expression profile chip datasets information...
Background: Hepatitis B virus infection is associated with liver disease, including cancers.In this study, we assessed the power of sex-determining region Y (SRY)-related high-mobility group (HMG)-box 4(SOX4) gene to predict clinical course hepatocellular carcinoma (HCC).Methods: To evaluate differential expression SOX4 and its diagnostic prognostic potential in HCC, analyzed GSE14520 dataset.Stratified analysis joint-effect were done using factor.We then designed a nomogram for predicting...