Postoperative ileus after colorectal surgery is a frequent problem that significantly delays recovery, increases perioperative costs, and negatively impacts on daily life, physical psychosocial functioning, wellbeing. We investigated the effect of acupuncture at different single acupoint combined with standard care postoperative ileus.In this single-centre, three-arm, prospective, randomised trial, we enrolled patients primary cancer undergoing elective resection Cancer Hospital Chinese...

As one effective treatment for lateral pelvic lymph node (LPLN) metastasis (LPNM), laparoscopic LPLN dissection (LPND) is limited due to the complicated anatomy of sidewall and various complications after surgery. With regard improving accuracy completeness LPND as well safety, we tried an innovative method using indocyanine green (ICG) visualized with a near-infrared (NIR) camera system guide detection LPLNs in patients middle-low rectal cancer.To investigate whether ICG-enhanced NIR...

Preoperative chemoradiotherapy (CRT), followed by total mesorectal excision, has become the standard of care for patients with clinical stages II and III rectal cancer. Patients pathologic complete response (pCR) to preoperative CRT have been reported better outcomes than those without pCR. However, factors that predict neoadjuvant not well defined. In this study, we aimed investigate impact parameters on development pCR after chemoradiation cancer.A 323 consecutive from a single institution...

Desmoid tumors are rare soft tissue with limited data on their management and prognosis. We sought to determine the rates of recurrence after surgery for desmoid analyze factors predictive recurrence-free survival (RFS). From February 1976 October 2011, 233 consecutive patients who underwent macroscopically complete resection were included in this study. Clinicopathologic treatment characteristics evaluated predictors recurrence. Patterns presentation primary (n = 156, 67.0 %) locally...

This study aims to investigate the feasibility, safety and efficacy of triplet regimen neoadjuvant chemotherapy in patients with locally advanced resectable colon cancer. Patients clinical stage IIIb cancer received a perioperative triple (oxaliplatin 85 mg/m2 irinotecan 150 mg/m2, combined folinic acid 200 mg, 5-fluorouracil 500 mg bolus then 2,400 by 44 h infusion or capecitabine 1 g/m2 S-1 40-60 b.i.d orally d 1-10, repeated at 2-week intervals) for 4 cycles. Complete mesocolic excision...

Micropores are one of the critical factors affecting materials’ performance and service life. As need for a deeper understanding micropore evolution damage mechanisms grows, assessing mechanical properties materials containing micropores predicting lifespan related metal structural components becomes increasingly complex. This paper focuses on process, regularities, research methods in materials. Based recent practical applications, key stages discussed, encompassing nucleation, growth,...

In the context of surgical treatment for rectal cancer, dentate line is acknowledged as a critical anatomical landmark. However, prognostic implications invasion (DLI) remain elusive and warrant further investigation. This study aims to evaluate compare outcomes patients with cancer who underwent abdominoperineal resection (APR), distinguishing between those without DLI. Between January 2006 December 2017, this enrolled 1854 APR. The cohort was divided into two groups, namely DLI group (n =...

Background The aim of this study was to evaluate the effect a longer interval between long-course neoadjuvant chemoradiotherapy and surgery on surgical oncologic outcome. Methods A total 233 consecutive patients with clinical stage II III rectal cancer were divided into 2 groups according neoadjuvant–surgery interval: short-interval group (≤7 weeks, n = 111), long-interval (>7 122). Data interval, operative time, perioperative complications, final pathology, disease recurrence, mortality...

This retrospective cohort study aimed to discuss the prognostic value of p53 positive in colorectal cancer. A total 124 consecutive patients diagnosed with cancer were evaluated at National Cancer Center/Cancer Hospital, Chinese Academy Medical Sciences and Peking Union College from 1 January 2009 31 December 2010. The expression was examined by immunohistochemistry. Based on levels p53, divided into a group negative group. In this study, 72 52 two groups well balanced gender, age, body mass...

Anastomotic leakage (AL) is a common complication after anterior resection of rectal cancer. Few studies have been conducted to determine whether the traditional predictors AL can be applied elderly patients (age ≥ 80) undergoing (AR) or low (LAR) This study was designed explore predictive factors for cancer in over 80 years old.From January 2007 May 2019, consecutive AR LAR at our institution were systematically reviewed. The general information, perioperative outcomes, and comorbidities...

Background Gastric signet ring cell carcinoma (GSRCC) is a rare and highly malignant disease with poor prognosis. To assess the overall survival (OS) cancer-specific (CSS) of patients GSRCC, prognostic nomograms were developed validated using common clinical factors. Methods This retrospective cohort study included diagnosed GSRCC between 2011 2018 from National Cancer Center (n = 1453) SEER databases 2745). Prognostic established by identifying independent factors univariate multivariate...

Abstract Risk assessment of esophageal squamous cell carcinoma (ESCC) is currently based on clinicopathological parameters. To identify genomic markers that can predict overall survival in ESCC, we performed array comparative hybridization (array CGH) a screening set 35 tumor samples from ESCC patients. Prognosis association the genes selected basis CGH results was further validated by real‐time PCR two independent sample sets ( n = 151 and 84). Genomic analysis revealed seven high‐level...

DNAJB6 is a member of the heat shock protein 40 (Hsp40) family. We here investigated clinical correlation and biological role overexpression in colorectal cancer (CRC). The expression was examined 200 cases adenocarcinomas by immunohistochemistry (IHC) technology. Gene transfection RNA interference were performed to determine effect on invasion CRC cells explore underlying molecular mechanisms vitro vivo. Overexpression found 39% (78/200) tissues, especially tumors at pT4 as compared with...

Transanal natural orifice specimen extraction (NOSE) in colorectal surgery has been introduced as a less invasive surgery. However, its long-term survival effects remain controversial. The aim of this study was to compare the short-term and outcomes transanal NOSE with those conventional laparoscopic approach mini-laparotomy (LAP) for anastomosis construction sigmoid colon cancer or rectal cancer.From January 2007 2018, retrospective conducted at China National Cancer Center. In total, 52...

The need or otherwise for lateral pelvic node dissection (LPND) in rectal cancer patients with clinical metastasis (LPNM) after neoadjuvant chemoradiotherapy (nCRT) is controversial. This study was designed to explore the predictive factors pathological LPNM nCRT.From January 2010 February 2018, a consecutive series of and nCRT who underwent total mesorectal excision LPND were reviewed. Patient demographics, operative outcomes collected analysed.A 76 cases included this study: 53 (69.7%)...

Background and Objective: Anastomotic leakage is one of the most serious complications after laparoscopic low anterior resection Low Anterior Resection (LAR) for rectal cancers. The purpose this study was to evaluate effectiveness a transanal drainage tube placed prevention anastomotic LAR. Methods: clinical data 220 patients with cancer who underwent LAR using double stapling technique Double Stapling Department Colorectal Surgery, National Cancer Center/National Clinical Research Center...

Abstract Background and Objectives There is no consensus on the safety indications of lateral pelvic lymph node dissection (LPND) for patients with clinical metastasis (LPNM) after neoadjuvant chemoradiotherapy (nCRT). Methods We retrospectively analyzed 151 who underwent total mesorectal excision (TME) + LPND divided them into two groups: nCRT group ( n = 73) non‐nCRT 78). Results Thirty‐one (20.5%) had LPNM by pathology. The operative time was significantly longer in (291.9 vs. 237.0 min,...

There is still controversy regarding the clinical value and significance of lateral pelvic lymph node (LPN) dissection (LPND). The present study aimed to investigate whether addition LPND total mesorectal excision (TME) confers survival benefits in rectal cancer patients with metastasis (LPNM).From January 2015 2021, a 141 evidence LPNM who underwent TME + were retrospectively analysed divided into group (n = 29) non-LPNM 112). was further subdivided high-risk 14) low-risk 15). Propensity...

Rectal cancer is one of the most common cancers in world. Early detection and early therapy are important for control death caused by rectal cancer. The present study aims to investigate genomic alterations adenoma carcinoma.We detected changes 8 adenomas carcinomas using array CGH. Then 14 genes were selected analyzing expression between tumor paracancerous normal tissues as well from carcinoma real-time PCR. GPNMB DIS3 further investigated immunohistochemistry.We indentified ten gains 22...

Ribosomal protein L34 antisense RNA 1 (RPL34-AS1) is novel long non-coding RNA, and was found to be down-regulated in colorectal cancer gastric cancer. The role of RPL34-AS1 still unknown esophageal In our study, we expression levels tissue specimens cell lines were lower than adjacent normal line, respectively. addition, patients with Ⅲ-Ⅳ, T3-T4 or positive lymph node metastasis had RPL34-AS1expression Ⅰ-Ⅱ, T1-T2 negative metastasis, survival analysis suggested low short overall those high...