A5020823421- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Hippo pathway signaling and YAP/TAZ
- Colorectal and Anal Carcinomas
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Wnt/β-catenin signaling in development and cancer
- Water resources management and optimization
- Cancer-related gene regulation
- Radiomics and Machine Learning in Medical Imaging
- Cancer Cells and Metastasis
- Hydrology and Watershed Management Studies
- Genomic variations and chromosomal abnormalities
- Cancer Genomics and Diagnostics
- Cancer therapeutics and mechanisms
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- PI3K/AKT/mTOR signaling in cancer
- Advanced MRI Techniques and Applications
- Esophageal Cancer Research and Treatment
- RNA Research and Splicing
Wuhan Third Hospital
2017-2025
Tongren Hospital
2017-2025
Thomas Jefferson University
2017-2025
Sidney Kimmel Cancer Center
2025
Second Affiliated Hospital of Nanchang University
2024
Nanchang University
2024
Zhongnan Hospital of Wuhan University
2023
Wuhan University
2017-2023
Huazhong University of Science and Technology
2014-2022
Renmin Hospital of Wuhan University
2017
The purpose of this study was to confirm that RRM2 as a novel target HPVE7 involved in cervical cancer angiogenesis. Gene expression analysed by RT-qPCR, western blot and immunohistochemistry tissue cell lines. Luciferase reporter assay used determine the activities various promoters. Secreted VEGF measured ELISA. RRM2-mediated capillary tube formation induced cells were evaluated using human umbilical vein endothelial vitro. ROS cercal confirmed flow cytometry. growth overexpression...
To improve the identification for CTCs with weak or negative CK and diploid in pancreatic cancer, we combined immune‐staining of CK, CD45, DAPI fluorescence situ hybridization centromere chromosome 8 (CEP8) probe method. 3.75 mL blood were depleted CD45 positive cells anti‐CD45 antibodies identified by combining CEP8 61 cases including 22 cancers, 3 borderline solid pseudopapillary tumors, 6 benign 30 healthy individuals. We found that enriched could be classified into 5 patterns:...
Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic disease. Body mass index (BMI) used obesity but has important limitations. The weight-adjusted waist (WWI) a novel metric and accurately reflects body composition. We explored association of WWI with all-cause cardiovascular (CVD) mortality in MASLD. Methods Adult participants MASLD were included from NHANES 1999-2018. was calculated by dividing circumference (WC) square root weight....
Pancreatic cancer (PC) is a highly invasive tumor with poor prognosis, short overall survival rate and few chemotherapeutic choices. Despite the importance of finding ways to treat pancreatic cancer, mechanisms progression have not been fully elucidated. microRNA-455-3p (miR-455-3p) has reported play an important role in several cancers, but its function remains unclear. To investigate biological functions, miRNAs mimics or inhibitors were transfected into cells. Flow cytometry was used...
BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is a of increasing global prevalence and an important risk factor for the development insulin resistance, type 2 diabetes, non-alcoholic steatohepatitis hepatocellular carcinoma, but pathogenesis not clear. The aim this study was to explore role ILF3 in NAFLD. AIM To investigate molecular processes through which facilitates advancement NAFLD by inhibiting expression p-AMPK. This exploration seeks provide new insights into etiology evaluate...
The Geriatric Depression Scale is a useful tool in screening for depression older adults, particularly vulnerable population oncology. National Comprehensive Cancer Network (NCCN) Distress Thermometer (DT) has been validated as fast and effective psychological distress general oncology populations, it could possibly be used surrogate the longer (GDS) test adults with cancer. In this retrospective cross-sectional study prior to starting cancer treatment, we evaluated relationship between DT...
Pancreatic cancer (PC) is a highly invasive tumor with early metastasis and poor prognosis, yet the mechanisms for progression have not been fully elucidated. Emerging evidence indicates that microRNA-331-3p (miR-331-3p) plays an important role in of diverse human cancers. Here, we found miR-331-3p was significantly upregulated specimens PC patients cell lines. Functional studies showed downregulation inhibited proliferation epithelial–mesenchymal transition (EMT)-mediated vitro....
Objective This study was performed to investigate the clinical characteristics of patients with coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome 2 (SARS-CoV-2). Methods We analyzed electronic medical records 405 hospitalized laboratory-confirmed COVID-19 in Third Hospital Wuhan. Results The patients’ median age 56 years, 54.1% were female, 11.4% had a history smoking, and 10.6% drinking. All cases community-acquired. Fever (76.8%) cough (53.3%) most...
Background: Pancreatic cancer is an aggressive type of with poor prognosis, short survival rate, and high mortality. Drug resistance a major cause treatment failure in the disease. MiR-331-3p has been reported to play important role several cancers. We previously showed that miR-331-3p upregulated pancreatic promotes cell proliferation epithelial-to-mesenchymal transition–mediated metastasis by targeting ST7L. However, it uncertain whether involved drug resistance. Methods: investigated...
Abstract Aim The main focus of this study is to explore the molecular mechanism IRF7 regulation on RPS18 transcription in M1‐type macrophages pancreatic adenocarcinoma (PAAD) tissue, as well transfer by via exosomes PAAD cells and ILF3 expression. Methods By utilising single‐cell RNA sequencing (scRNA‐seq) data spatial transcriptomics (ST) from Gene Expression Omnibus database, we identified distinct cell types with significant expression differences tissue. Among these types, those closely...
Abstract Risk assessment of esophageal squamous cell carcinoma (ESCC) is currently based on clinicopathological parameters. To identify genomic markers that can predict overall survival in ESCC, we performed array comparative hybridization (array CGH) a screening set 35 tumor samples from ESCC patients. Prognosis association the genes selected basis CGH results was further validated by real‐time PCR two independent sample sets ( n = 151 and 84). Genomic analysis revealed seven high‐level...
Pancreatic cancer cells are characterized by high cell proliferation and low apoptosis, but the factors involved in these processes remain to be further studied. In this study, we report that miR-324-5p regulates apoptosis of pancreatic through regulating expression Krüppel-like factor 3 (KLF3). both tissues lines, levels significantly increased. Inhibition represses promotes whereas overexpression exerts opposite effect. Furthermore, identified KLF3, a as new direct downstream target...
To evaluate the effectiveness of both synthetic magnetic resonance imaging (SyMRI) and conventional diffusion-weighted (DWI) for identifying human epidermal growth factor receptor 2 (HER2) status in breast cancer (BC) patients.
There is growing evidence that long non-coding RNAs (lncRNAs) are significant contributors to the epigenetic mechanisms implicated in emergence, progression and metastasis of colorectal cancer (CRC), but many remain underexplored. A novel lncRNA LOC105369504, was identified be a potential functional by microarray analysis. In CRC, expression LOC105369504 markedly decreased resulted distinct variations proliferation, invasion, migration epithelial-mesenchymal transition (EMT) vivo vitro. This...
Noscapine is an opium alkaloid that has recently been shown to potentiate anti-cancer therapeutic effects by inducing apoptosis in various malignant cells without any detectable toxicity. However, the mechanism which noscapine induces colon cancer remains unclear.In this study, we explored activity of 5-fluorouracil (5-FU)-resistant human cell lines HT29/5-FU and LoVo/5-FU investigated possible underlying mechanism. The mitochondrial morphology were detected TUNEL assay transmission electron...
αB-Crystallin (CRYAB) is differentially expressed in various tumors. However, the correlation between CRYAB and immune cell infiltration colorectal cancer (CRC) remains unclear.Kaplan-Meier survival curves The Cancer Genome Atlas (TCGA) were used to evaluate relationship expression both overall progression-free survival. relationships infiltrating cells their corresponding gene marker sets examined using TIMER database.The of was lower CRC tumor tissues than normal (P < 0.05). High high...
Abstract Background Chromosomal and genomic aberrations are common features of human cancers. However, chromosomal numerical structural aberrations, breakpoints disrupted genes have yet to be identified in esophageal squamous cell carcinoma (ESCC). Methods Using multiplex-fluorescence situ hybridization (M-FISH) oligo array-based comparative (array-CGH), we six ESCC lines. Furthermore, detected recurrent primary tumors by dual-color FISH. Results M-FISH array-CGH results revealed complex...
Cadherin-17 (CDH17), a structurally unique member of the non-classical cadherin family, is associated with poor survival, cell proliferation, and metastasis in colorectal cancer. However, role CDH17 apoptosis autophagy cancer cells remains unclear. Here, we aimed to investigate effect knockdown on cells. We inhibited expression KM12SM KM12C by RNA interference found that silencing significantly viability increased In addition, cleaved caspase-3 Bax decreased Bcl-2. Concurrently, conversion...
Abstract Background Globally, gastric cancer (GC) is one of the world’s most widespread malignancies, with persistent high mortality and morbidity rates. Increasing evidence now suggests that microRNAs (miRNAs) participate in many biological processes, miR-455-3p having key roles progression diverse cancers. Nevertheless, function expression GC remain unclear. Methods We explored using quantitative polymerase chain reaction (qPCR). To further examine effect GC, after transfecting mimics or...