A5100717398- Aquaculture disease management and microbiota
- Immune Response and Inflammation
- Microplastics and Plastic Pollution
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Advanced Glycation End Products research
- Neutrino Physics Research
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- biodegradable polymer synthesis and properties
- Recycling and Waste Management Techniques
- Astrophysics and Cosmic Phenomena
- Magnolia and Illicium research
- Lipid metabolism and biosynthesis
- Invertebrate Immune Response Mechanisms
- Extracellular vesicles in disease
- Myxozoan Parasites in Aquatic Species
- Ferroptosis and cancer prognosis
- Fluorine in Organic Chemistry
- Antimicrobial Peptides and Activities
- Iron Metabolism and Disorders
- Alkaloids: synthesis and pharmacology
- Dark Matter and Cosmic Phenomena
- Neonatal and Maternal Infections
- Atomic and Subatomic Physics Research
- Liver Disease Diagnosis and Treatment
Wuhan Third Hospital
2023-2025
Institute of High Energy Physics
2025
Tongren Hospital
2024-2025
University of Electronic Science and Technology of China
2023-2024
Zhongnan Hospital of Wuhan University
2023-2024
Wuhan University
2023-2024
Northwest A&F University
2021-2024
Xuzhou Medical College
2023
Nanjing University of Chinese Medicine
2023
Sichuan Agricultural University
2020-2022
A simple, efficient, and convenient activation of perfluoroalkyl iodides by tBuONa or KOH, without expensive photo- transition metal catalysts, allows the promotion versatile α-sp3 C-H amidation reactions alkyl ethers benzylic hydrocarbons, iodination heteroaryl compounds, perfluoroalkylations electron-rich π bonds. Mechanistic studies show that these novel protocols are based on halogen bond interaction between which promote homolysis under mild conditions.
BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is a of increasing global prevalence and an important risk factor for the development insulin resistance, type 2 diabetes, non-alcoholic steatohepatitis hepatocellular carcinoma, but pathogenesis not clear. The aim this study was to explore role ILF3 in NAFLD. AIM To investigate molecular processes through which facilitates advancement NAFLD by inhibiting expression p-AMPK. This exploration seeks provide new insights into etiology evaluate...
Abstract Aim The main focus of this study is to explore the molecular mechanism IRF7 regulation on RPS18 transcription in M1‐type macrophages pancreatic adenocarcinoma (PAAD) tissue, as well transfer by via exosomes PAAD cells and ILF3 expression. Methods By utilising single‐cell RNA sequencing (scRNA‐seq) data spatial transcriptomics (ST) from Gene Expression Omnibus database, we identified distinct cell types with significant expression differences tissue. Among these types, those closely...
Abstract Background Globally, gastric cancer (GC) is one of the world’s most widespread malignancies, with persistent high mortality and morbidity rates. Increasing evidence now suggests that microRNAs (miRNAs) participate in many biological processes, miR-455-3p having key roles progression diverse cancers. Nevertheless, function expression GC remain unclear. Methods We explored using quantitative polymerase chain reaction (qPCR). To further examine effect GC, after transfecting mimics or...
The data that support the findings of this study are available from corresponding author upon reasonable request.
NLRs are important intracellular pattern recognition receptors and play an essential role in innate immunity for vertebrates. However, research on sturgeon is still scarce. In this study, the NLRC3-like gene from Siberian (Acipenser baerii) (AbNLRC3-like) was cloned characterized. The AbNLRC3-like full-length cDNA composed of 3310 bp with a 166 5′-UTR, 2838 open reading frame (ORF) 306 3′-UTR, encoding 945 amino acids. Structural analysis showed typical structure, including central NACHT...
为了解齐口裂腹鱼高迁移率蛋白B1 ( Schizothorax prenanti high mobility group box 1，SpHMGB1)的序列特征及其与嗜水气单胞菌胁迫的相关性，实验根据齐口裂腹鱼脾脏TSA库中获得的序列设计引物，采用克隆技术克隆 SpHMGB 1的核心序列并进行生物信息学分析，采用实时荧光定量PCR (qPCR)技术检测嗜水气单胞菌在体和离体胁迫后组织和巨噬细胞中 1的响应情况。序列分析结果显示， 1开放阅读框长为615 bp，编码204个氨基酸，理论分子量为23.5 ku，等电点为6.79，包含2个基本的HMG盒：A盒和B盒，以及一个酸性尾巴。SpHMGB1二级结构主要由47.06%的α-螺旋和50%的无规则卷曲构成。系统进化树分析显示，SpHMGB1与鱼类HMGB1聚为一支，与斑马鱼和鲫的亲缘关系最近，氨基酸一致性分别为90.7%和90.4%。qPCR检测结果显示，嗜水气单胞菌感染后 1具有不同的时空表达趋势，其中血液在72 h表达量最高，肾脏在6 h表达量最高，脾脏在120 h表达量最高；热灭活嗜水气单胞菌刺激巨噬细胞后，...
Abstract Objective High-mobility group box 1 (HMGB1) is a highly conserved nuclear protein and participates in the immune response to pathogens bony fish. In this study, structure function of HMGB1 cyprinid fish Schizothorax prenanti (SpHMGB1) were investigated. Methods The spatial SpHMGB1 was predicted by CPHmodels. Quantitative reverse transcription PCR used detect mRNA different tissues Streptococcus agalactiae infection. macrophage treated with synthetic SpHMGB1-B peptide analyze...
Abstract Background Certain members of the Procollagen-lysine 2-oxyglutarate 5-dioxygenase (PLOD) family have been identified to play a role in tumor metastasis and progression. Materials & Methods The association between PLOD expression overall survival (OS) rates was assessed utilizing Kaplan-Meier curve. correlation gene patient OS rate determined univariate or multivariate Cox proportional hazards regression model log-rank test evaluate difference rates. infiltration levels stromal...
Abstract Objective and design IL-12 is a well-recognized pro-inflammatory cytokine with multi-functions in participating mammalian innate immunity, but little known regarding the details for protecting skin barrier damage lower vertebrates. The aim of this study was to evaluate effects mechanisms its key effectors promoting wound repair teleosts. Material or subjects Recombinant gcIL-12BB (rgcIL-12BB) employed investigate roles teleost healing. Meanwhile, regulatory rgcIL-12BB on...