A5101866202- Cancer-related molecular mechanisms research
- Nuclear Receptors and Signaling
- MicroRNA in disease regulation
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Health Promotion and Cardiovascular Prevention
- Antiplatelet Therapy and Cardiovascular Diseases
- Macrophage Migration Inhibitory Factor
- RNA regulation and disease
- Liver Disease Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac and Coronary Surgery Techniques
- Chronic Disease Management Strategies
- Biliary and Gastrointestinal Fistulas
- Ferroptosis and cancer prognosis
- Vasculitis and related conditions
- Pancreatitis Pathology and Treatment
- Lipoproteins and Cardiovascular Health
- Circular RNAs in diseases
- Otolaryngology and Infectious Diseases
- Parkinson's Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Infectious Diseases and Tuberculosis
- Healthcare Systems and Public Health
Guizhou Provincial People's Hospital
2013-2024
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2024
Third Affiliated Hospital of Guangzhou Medical University
2021
Guangzhou Medical University
2021
Southern Medical University
2021
Guangdong Provincial Center for Disease Control and Prevention
2021
Zhujiang Hospital
2021
Abstract Vascular calcification is a common pathologic condition in patients with chronic kidney disease (CKD) and aging individuals. It has been established that vascular gene‐regulated biological process resembling osteogenesis involving osteogenic differentiation. However, there no efficient treatment available for so far. The natural polyamine spermidine demonstrated to increase life span protect against cardiovascular disease. unclear whether supplementation inhibits CKD. Alizarin red...
Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic disease. Body mass index (BMI) used obesity but has important limitations. The weight-adjusted waist (WWI) a novel metric and accurately reflects body composition. We explored association of WWI with all-cause cardiovascular (CVD) mortality in MASLD. Methods Adult participants MASLD were included from NHANES 1999-2018. was calculated by dividing circumference (WC) square root weight....
Background: This study is conducted to investigate the protective role of elevated microRNA-375 (miR-375) in dopaminergic neurons Parkinson's disease through down-regulating transcription factor specificity protein 1 (SP1).Results: The successfully modeled rats with showed aggregated neurobehavioral change, increased neuroinflammatory response and oxidative stress, lowered dopamine content.Parkinson's treated overexpressed miR-375 displayed improved ameliorated heightened content abated...
This research was aimed to investigate the effects of baicalin on 6-hydroxydopamine (6-OHDA)-induced rat model Parkinson's disease (PD) and main mechanism based metabolomics.The PD induced by 6-OHDA. The protective were evaluated open field test rotarod test. anti-PD efficacy examining morphologic changes neurons level monoamine neurotransmitters in striatum, number morphology tyrosine hydroxylase (TH)-positive neurons, oxidative stress. Combined with metabolomics methods, pharmacodynamic...
Objectives Early brain injury (EBI) is considered to be one of the main causes poor outcome in subarachnoid hemorrhage (SAH) patients. Bexarotene an agonist retinoid X receptor and plays a protective role central nervous system diseases. However, exact bexarotene SAH has not been reported. Therefore, present study was determine whether administration attenuate EBI after mice explore underlying mechanism. Methods induced C57BL/6 by endovascular perforation. administrated intraperitoneally....
Homeobox transcript antisense RNA (HOTAIR), has been associated with neuroprotective effects in Parkinson's disease (PD). However, the underlying mechanisms still remain unclear. Hence, this present study attempted to clarify functional relevance of HOTAIR PD. We established an vivo mouse model PD using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and vitro cell by treating dopaminergic neuron MN9D cells 1-methyl-4-phenylpyridinium species (MPP
LINGO-1 may be involved in the pathogenesis of cerebral ischemia. However, its biological function and underlying molecular mechanism ischemia remain to further defined. In our study, middle artery occlusion/reperfusion (MACO/R) mice model HT22 cell oxygen-glucose deprivation/reperfusion (OGD/R) were established simulate pathological process vivo vitro detect relevant mechanism. We found that mRNA protein upregulated models. Down-regulation improved neurological symptoms reduced changes...
To evaluate and compare the predictive value of short-term risk death global registry acute coronary events (GRACE) scores, physiology chronic health evaluation II (APACHEII) scores rapid emergency medicine score (REMS) in patients with myocardial infarction (AMI).A retrospective review clinical data 390 AMI admitted from October 2012 to March 2013 department cardiology care unit (CCU) Guizhou People's Hospital were performed. The lowest within 24 hours GRACE score, APACHEII REMS...
Angiitis, also known as vasculitis, is a chronic inflammatory disease characterized by the infiltration of cells in surroundings blood vessels, accompanied vascular damage including fibrin deposition, collagen fiber degeneration, myocyte, and endotheliocyte necrosis. This work aimed to perform an integrated bioinformatic analysis three data sets concerning vasculitis explore examine potential diagnostic therapeutic makers contributing illuminating pathomechanisms vasculitis. We collected...
Pulmonary fibrosis (PF) is the major complication and death-related factor of acute respiratory distress syndrome (ARDS).This study evaluated significance miR-141-3p in ARDS its PF aiming to identify a potential biomarker for screening predicting occurrence PF.A total 137 patients 69 healthy individuals were enrolled this serum samples collected from all participants.The levels analyzed by polymerase chain reaction.The diagnosis development was receiver operating curve, chi-square test,...
Hepatic artery aneurysm rupture is a rare cause of massive hemobilia, which potentially life-threatening, upper gastrointestinal hemorrhage. Cases mycotic hepatic associated with streptococcal endocarditis have rarely been reported. In the present study, we report case hemobilia that was caused by ruptured in patient who infected 3 months previously. Transarterial embolization failed, possibly due to vascular variations. However, surgical treatment successfully performed, and completely...
OBJECTIVE To investigate the protective effect of platelet-rich plasma (PRP) against acute myocardial ischemiareperfusion (IR) injury and possible mechanism. Aortic blood samples were collected from 10 SD rats to prepare PRP, in which concentrations platelet-derived growth factor-BB (PDGF-BB) transforming factor-β1 (TGF-β1) measured. Cell models IR established primary cultures neonatal rat cardiomyocytes by exposing cells 3 h hypoxia. The then reoxygenated co-cultured with 1%, 5%, 10%, 20%...
Objective:To study the etiology, presentation, diagnosis and treatment of infection deep neck space with superior mediastinal in order to accumulate experience clinical treatment.Method:We reviewed medical records 15 patients who were diagnosed those hospitalized Guizhou provincial people's hospital from Janurary 2011 July 2015.The screened retrospectively for demographic characteristics, presenting symptoms, laboratory examinations, imaging features, bacteriologies etiologies. The outcomes...