A5102942655- Corneal Surgery and Treatments
- Cancer, Hypoxia, and Metabolism
- Burn Injury Management and Outcomes
- Nitric Oxide and Endothelin Effects
- Intracerebral and Subarachnoid Hemorrhage Research
- Proteoglycans and glycosaminoglycans research
- Metabolism, Diabetes, and Cancer
- Anesthesia and Neurotoxicity Research
- Ocular Surface and Contact Lens
- Anesthesia and Sedative Agents
- Folate and B Vitamins Research
- Orthopaedic implants and arthroplasty
- Protein purification and stability
- Cardiac Ischemia and Reperfusion
- Esophageal Cancer Research and Treatment
- Forensic Entomology and Diptera Studies
- Signaling Pathways in Disease
- NF-κB Signaling Pathways
- Protein Interaction Studies and Fluorescence Analysis
- Neonatal and fetal brain pathology
- Syphilis Diagnosis and Treatment
- Sphingolipid Metabolism and Signaling
- Physiological and biochemical adaptations
- High Altitude and Hypoxia
- Adipokines, Inflammation, and Metabolic Diseases
Fudan University
2025
Chinese PLA General Hospital
1996-2025
Shanghai University of Sport
2025
Weatherford College
2024
Southern Medical University
2010-2022
Guangzhou Medical University
2021
Third Affiliated Hospital of Guangzhou Medical University
2021
China-Japan Friendship Hospital
2017
Zhujiang Hospital
2012-2016
Shanghai Jiao Tong University
2014
Purpose: To explore the pathological differences in orbital adipose/connective tissue between active and inactive thyroid eye disease (TED) subjects their correlations with clinical characteristics. Methods: Orbital samples from 42 TED (20 active, 22 inactive) were collected during decompression surgery. We analyzed cytokine expression, inflammatory cell infiltration, inherent populations, interstitial changes by Luminex histopathology. Correlations using Pearson Spearman correlation...
<b><i>Purpose:</i></b> This study was undertaken to investigate the effects of recombinant human epidermal growth factor (rhEGF) and basic fibroblast (bFGF) on corneal wound healing neovascularization (CNV). <b><i>Methods:</i></b> The positive 10 ng/ml rhEGF bFGF proliferation epithelial cells (SD-HCEC1s), rabbit keratocyte (RKCs) umbilical vein endothelial (HUVECs) as well migration capacity HUVECs were observed. An animal central CNV model...
Backgrounds: Our previous work revealed that AMP-activated protein kinase (AMPK) activation inhibits vascular smooth muscle cell migration in vitro by phosphorylating PDZ and LIM domain 5 (Pdlim5). As metformin is an AMPK activator, we used a mouse (VSMC) line Myh11-cre-EGFP mice to investigate whether could inhibit the of VSMCs wire-injury model vivo . It recognized contribute major composition atherosclerotic plaques. In order AMPK–Pdlim5 pathway involved protective function against...
Background: Infants undergoing magnetic resonance imaging (MRI) often require pharmacological sedation. Dexmedetomidine serves as a novel sedative agent that induces unique unconsciousness similar to natural sleep, and therefore has currently been used the first choice for sedation in infants young children. Objective: To determine 50% effective dose (ED50) 95% confidence interval (95%CI) of intranasal dexmedetomidine MRI preterm term infants, observe incidence adverse events. explore...
Several mitogen-activated protein kinases (MAPKs) are activated during thermal injury, and the p38 MAPK is specifically involved in endothelial cell (EC) actin myosin rearrangement (stress-fiber formation) with ensuing cellular contraction enhanced vessel permeability. Inhibition of extracellular signal-related kinase by their inhibitors SB203580 PD98059, respectively, significantly reduces burn serum-induced EC stress-fiber formation, whereas also inhibits tight-junction damage thereby...
Podocytes are highly differentiated epithelial cells that form interdigitating foot processes with bridging slit diaphragms (SDs) regulate renal ultrafiltration. Proteinuria is the most common clinical manifestation of glomerular diseases. Losartan traditional renin–angiotensin system (RAS). However; precise mechanisms underlying beneficial effects on podocytes still unknown. This study tested hypothesis were exposed to Angiotensin II (Ang II) induce apoptosis and Proteinuria. directly...
Objective: To disclose the correlation between femur bowing angle(FBA) and vulgas correction angle(VCA), anlysys its influence on total knee arthroplasty lower limbs alignment. Methods: From Janurary 2013 to December 2015, 699 patients who had received arthroplasty(TKA)were collected in Department of Joint Surgery, China-Japan Friendship. The FBA, VCA, offset proximal femur, lengh neck shaft angle eligible cases from long leg X-ray were measured.All data analysed for following steps: FBA's...
G2/M checkpoints ensure the proper timing of cell mitosis. We previously reported that p38 mitogen‐activated protein kinase ( MAPK ) activation is essential for stress‐induced G2 arrest in U‐2 OS osteosarcoma line, but molecular mechanism was obscure. Here, using T7 phage display system, we find directly binds to human polycomb 2 HPC 2), and arsenate‐induced p38‐ phosphorylation 2‐dependent. Phosphorylation at threonine 495 required recruiting Ring1 Rb family proteins form repressive complex...
The effects of advanced glycation end products(AGE)on phosphorylation ezrin/radixin/ moesin(ERM)protein in human umbilical vein endothelial ceils were detected by immunofluorescence cytochemistry and its mechanism was explored.AGE stimulated the ERM protein dose-and time-dependent manners(all P<0.05),which involved AGE receptor,Rho kinase,and p38 mitogen-activated kinase pathways. Key words: Glycation products; advanced; Ezrin/radixin/moesin; Mitogen-activated kinase; Rho
ObjectiveInvestigate the effect and mechanism of metformin on development metabolic syndrome related atherosclerosis.MethodTransfecting EGFP-CLIP170 or EGFP-Pdlim5 plasmid to mouse aortic smooth muscle cell line, test expression p-AMPK, pCLIP-170 pPdlim5, observe microtubule actin skeleton system by immunofluorescence staining. Scratch cells perform wound healing experiment, stimulating with gradient (0, 0.5, 1 mmol/L) for 8 h, change scratch size dynamic migration in vitro. ApoE-/- mice...
While impairment of vascular homeostasis induced by hypercholesterolemia is the first step cardiovascular diseases, molecular mechanism behind such not well known. Here, we reported that high-cholesterol diet (HCD) defective vessel sprouting in zebrafish larvae. Electron transfer flavoprotein subunit α (ETFα) (encoded ETFA gene), a protein mediates electrons from series mitochondrial flavoenzymes to respiratory chain, was downregulated HCD-fed and endothelial cells treated with oxidized...
OBJECTIVE To investigate the protective effect of platelet-rich plasma (PRP) against acute myocardial ischemiareperfusion (IR) injury and possible mechanism. Aortic blood samples were collected from 10 SD rats to prepare PRP, in which concentrations platelet-derived growth factor-BB (PDGF-BB) transforming factor-β1 (TGF-β1) measured. Cell models IR established primary cultures neonatal rat cardiomyocytes by exposing cells 3 h hypoxia. The then reoxygenated co-cultured with 1%, 5%, 10%, 20%...