A5101541411- Cancer-related molecular mechanisms research
- RNA regulation and disease
- Neurological Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Hereditary Neurological Disorders
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurogenetic and Muscular Disorders Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Renal and Vascular Pathologies
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neuropharmacology Research
- Ferroptosis and cancer prognosis
- Atherosclerosis and Cardiovascular Diseases
- RNA Research and Splicing
- Cancer-related gene regulation
- Neurosurgical Procedures and Complications
- Neurological diseases and metabolism
Guizhou Provincial People's Hospital
2017-2024
Qujiang People's Hospital
2022
Guizhou University
2018
Background: This study is conducted to investigate the protective role of elevated microRNA-375 (miR-375) in dopaminergic neurons Parkinson's disease through down-regulating transcription factor specificity protein 1 (SP1).Results: The successfully modeled rats with showed aggregated neurobehavioral change, increased neuroinflammatory response and oxidative stress, lowered dopamine content.Parkinson's treated overexpressed miR-375 displayed improved ameliorated heightened content abated...
This research was aimed to investigate the effects of baicalin on 6-hydroxydopamine (6-OHDA)-induced rat model Parkinson's disease (PD) and main mechanism based metabolomics.The PD induced by 6-OHDA. The protective were evaluated open field test rotarod test. anti-PD efficacy examining morphologic changes neurons level monoamine neurotransmitters in striatum, number morphology tyrosine hydroxylase (TH)-positive neurons, oxidative stress. Combined with metabolomics methods, pharmacodynamic...
Background Ferroptosis, a newly proposed concept of programmed cell death, has garnered significant attention in research across different diseases the last decade. Despite thorough citation analyses neuroscience, there is scarcity information on ferroptosis specifically related to neurodegenerative diseases. Method The Web Science Core Collection database retrieved relevant articles and reviews. Data publications, countries, institutions, authors, journals, citations, keywords included...
Background: Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been shown to be involved in Parkinson's disease (PD) progression, but its mechanism needs further explored. Methods: Mice were injected with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induce PD mice models, and BV2 cells treated lipopolysaccharides (LPS) mimic cell models. MALAT1 expression suppressor of cytokine signaling 3 (SOCS3) protein level examined using quantitative real-time...
Objectives Early brain injury (EBI) is considered to be one of the main causes poor outcome in subarachnoid hemorrhage (SAH) patients. Bexarotene an agonist retinoid X receptor and plays a protective role central nervous system diseases. However, exact bexarotene SAH has not been reported. Therefore, present study was determine whether administration attenuate EBI after mice explore underlying mechanism. Methods induced C57BL/6 by endovascular perforation. administrated intraperitoneally....
Homeobox transcript antisense RNA (HOTAIR), has been associated with neuroprotective effects in Parkinson's disease (PD). However, the underlying mechanisms still remain unclear. Hence, this present study attempted to clarify functional relevance of HOTAIR PD. We established an vivo mouse model PD using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and vitro cell by treating dopaminergic neuron MN9D cells 1-methyl-4-phenylpyridinium species (MPP
Background: LncRNAs perform a crucial impact on microglia’s activation in Parkinson’s disease (PD). Here, our purpose was to probe the function and involved mechanism of lncRNA SOX21-AS1 microglial PD. Methods: Mice were treated with MPTP, BV2 cells LPS/ATP build PD animal cell models. Genes’ expression measured using RT-qPCR, immunoblotting, IHC stain. ELISA applied for testing inflammatory factors’ levels. Cell viability apoptosis tested kits. RIP RNA pull-down assay utilized monitoring...