A5091455947- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Medical Imaging and Pathology Studies
- Connective tissue disorders research
- Growth Hormone and Insulin-like Growth Factors
- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Treatments and Mutations
- Extracellular vesicles in disease
- Scoliosis diagnosis and treatment
- Tracheal and airway disorders
China-Japan Friendship Hospital
2019-2024
Peking Union Medical College Hospital
2015-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2023
Academia Sinica
2020
Academy of Medical Sciences
2020
This study investigated whether programmed death-ligand 1 (PD-L1) expression of circulating tumor cells (CTCs) in peripheral blood can serve as a predictive biomarker for immunotherapy efficacy patients with advanced non-small-cell lung cancer (NSCLC).We employed negative enrichment method to isolate CTCs. We identified PD-L1 + CTCs PD-L1+/4',6-diamidino-2-phenylindole (DAPI)+/CD45-circulating through an immunofluorescence method. Tumor tissue was determined by immunohistochemical staining....
The utility of circulating tumor cells (CTCs) as prognostic biomarkers in non-small cell lung cancer (NSCLC) is inconclusive due to the limitations current CTC detection methods. Using a novel high-efficiency method, we determined ability CTCs predict survival and chemotherapeutic responses NSCLC. In 127 patients with advanced NSCLC, were counted analyzed at baseline during follow-up. Median overall (OS) progression-free (PFS) longer counts <8 CTCs/3.2 mL (20.0 vs. 10.4 months [P = 0.009]...
BackgroundImmunotherapy is a promising advance in oncology. Limited information exists regarding the interrelationship between CD47 expression and tumour-associated macrophage-related immuno-microenvironment patients with non-small cell lung cancer (NSCLC). These factors may predict novel immunotherapy efficacy.Patients methodsCD47 PD-L1 was retrospectively assessed 191 resected NSCLC specimens via immunohistochemistry. Forty-six pulmonary infectious diseases were enrolled as control group....
Circulating tumor cell (CTC) counts at baseline and follow-up are an independent prognostic factor in patients receiving standard chemotherapy for non-small lung cancer (NSCLC). This study further explored the role of CTCs EGFR-mutated ALK-rearranged NSCLC administered targeted therapies as first-line treatment.
Accurate differentiation between malignant and benign pulmonary nodules, especially those measuring 5-10 mm in diameter, continues to pose a significant diagnostic challenge. This study introduces novel, precise approach by integrating circulating cell-free DNA (cfDNA) methylation patterns, protein profiling, computed tomography (CT) imaging features enhance the classification of nodules.
BACKGROUND Adolescent idiopathic scoliosis (AIS) is the most common spinal deformity, but its etiology unclear. Multiple genetic mutations have been reported to be associated with AIS. MATERIAL AND METHODS We enrolled a cohort of 113 surgically treated AIS patients available parental subjects from Peking Union Medical College Hospital. performed whole-exome sequencing in 10 trio families and whole-genome 103 singleton patients. Luciferase assay was used detect functional alterations...
e20531 Background: Immunotherapy is one of the most promising advances in field oncology. However, limited information exists regarding characterization tumor associated macrophages (TAMs) related immune microenvironment patients with non-small cell lung cancer (NSCLC), by which it may possible to predict efficacy novel immunotherapies. Methods: 191 resected NSCLC specimens were retrospectively studied for expression CD47 was examined using immunohistochemistry (IHC). The infiltration TAMs...
Background: Immunotherapy is among the most promising advances in oncology. Limited information exists regarding interrelationship between CD47 expression and tumour-associated macrophage-related immune microenvironment patients with non-small cell lung cancer (NSCLC). These factors may predict novel immunotherapy efficacy.Methods: PD-L1 was retrospectively studied 191 resected NSCLC specimens using immunohistochemistry. Additionally, 46 cases pulmonary infectious diseases were enrolled as a...
8568 Background: Low dosage computer tomography (LDCT) has been widely adopted as a sensitive method to detect early-stage lung cancer; however, debate regarding its accuracy and overdiagnosis is still ongoing. An accurate non-invasive test needed identify malignant nodules reduce unnecessary invasive procedures. Studies show that plasma proteins LDCT imaging features may be used discriminate pulmonary from benign ones. We aimed develop combinatorial approach integrating serum protein...
Abstract Background: Immunotherapy is one of the most promising advances in field oncology. However, limited information exists regarding characterization tumor associated macrophages (TAMs) related immune microenvironment patients with non-small cell lung cancer(NSCLC), by which it may possible to predict efficacy novel immunotherapies. Method: 191 resected NSCLC specimens were retrospectively studied for CD47 expression & PD-L1 examined using immunohistochemistry (IHC). The...