A5066194861- Reproductive Biology and Fertility
- Lung Cancer Treatments and Mutations
- Ovarian function and disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Prenatal Screening and Diagnostics
- Reproductive System and Pregnancy
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Genomic variations and chromosomal abnormalities
- Immune cells in cancer
- Lung Cancer Research Studies
- Ubiquitin and proteasome pathways
- Medical Imaging and Pathology Studies
- Cancer, Hypoxia, and Metabolism
- Reproductive Health and Technologies
- Cytokine Signaling Pathways and Interactions
- Endometriosis Research and Treatment
- Mesenchymal stem cell research
- Bacterial Genetics and Biotechnology
- HER2/EGFR in Cancer Research
- Neurofibromatosis and Schwannoma Cases
- Lung Cancer Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Renal and related cancers
- Cancer Mechanisms and Therapy
Wuhan University
2023-2025
Renmin Hospital of Wuhan University
2023-2025
Wuhan Donghu University
2024
South China Agricultural University
2024
Dalian University
2022-2024
Dalian University of Technology
2022-2024
Tsinghua University
2022-2024
Nanjing University
2024
Ministry of Agriculture and Rural Affairs
2024
Hebei Medical University
2009-2023
Abstract Although GPR3 plays pivotal roles in both the nervous system and metabolic processes, such as cold-induced thermogenesis, its endogenous ligand remains elusive. Here, by combining structural approach (including cryo-electron microscopy), mass spectrometry analysis, functional studies, we identify oleic acid (OA) an of GPR3. Our study reveals a hydrophobic tunnel within that connects extracellular side receptor to middle plasma membrane, enabling fatty acids readily engage receptor....
Abstract Leukotriene B4 receptor 1 (BLT1) plays crucial roles in the acute inflammatory responses and is a valuable target for anti-inflammation treatment, however, mechanism by which leukotriene (LTB4) activates remains unclear. Here, we report cryo-electron microscopy (cryo-EM) structure of LTB4 -bound human BLT1 complex with G i protein an active conformation at resolution 2.91 Å. In combination molecule dynamics (MD) simulation, docking site-directed mutagenesis, our reveals that...
Chronic endometritis (CE) has been considered to reduce uterine receptivity and negatively affect reproductive outcomes for in vitro fertilization-embryo transfer (IVF-ET) patients, especially people undergoing recurrent implantation failure (RIF). To investigate the effects of antibiotic platelet-rich plasma (PRP) therapy on pregnancy following frozen-thawed embryo (FET) RIF patients with CE, endometrial specimens 327 obtained by scratching during mid-luteal phase were immunostained...
Abstract Background Women diagnosed with gestational diabetes mellitus often rely on internet-based health information for managing their condition. This study aims to investigate the present state of electronic literacy among women mellitus, analyze influencing factors, and explore experiences regarding accessing, comprehending, evaluating, applying online pertinent mellitus. Methods A sequential explanatory mixed methods research design was adopted in this study. Initially, 235...
ABSTRACT Donation‐based crowdfunding platforms have increasingly applied disclosure strategies to encourage potential donors contribute. However, most existing research has not studied the efficacy of showing donors' information by considering tie strength between disclosed and donors. This was intended investigate interactive effects disclosing on donation amounts, employing conceptual frameworks we‐mode I‐mode. Through three online between‐subject experiments ( N total = 801), we found...
The global incidence of infertility is increasing, and has become an important medical social issue. With the widespread application in vitro fertilization-embryo transfer (IVF-ET) technology, mental health problems patients undergoing this treatment have gradually attracted attention. purpose study was to explore relationships among level hope, fertility quality life negative emotions who underwent IVF-ET for first time provide a scientific basis subsequent psychological support...
Abstract Binding of precursor tRNAs (ptRNAs) by bacterial ribonuclease P (RNase P) involves an encounter complex (ES) that isomerizes to a catalytic conformation (ES*). However, the structures intermediates and conformational changes occur during binding are poorly understood. Here, we show pairing between 5′ leader 3′RCCA extending acceptor stem ptRNA inhibits ES* formation. Cryo-electron microscopy single particle analysis reveals dynamic enzyme becomes ordered upon formation in which...
Oocyte maturation arrest at metaphase I leads to fertilization failure in humans. In early embryos, the tubulin beta 8 class VIII (TUBB8) encodes a β-tubulin isotype and aids assembling of human oocyte spindle. Mutations TUBB8 potentially interfere with maturation-a crucial prerequisite for subsequent embryonic development. This study aims investigate novel mutations their prevalence. Hundred fertile women (controls) eleven infertile were chosen study. A total five heterozygous/homozygous...
Objective To evaluate the associations between homeostatic model assessment for insulin resistance (HOMA-IR) and pregnancy outcomes in non-dyslipidemic infertile women undergoing vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET). Materials Methods This is a retrospective study involving 3,615 who attend to Reproductive Medicine Center of Xiangya Hospital, Central South University (CSU) January 2014 October 2021. Eligible participants were divided into three...
Abstract Background It was been agreed that significantly elevated progesterone level on the hCG trigger day have detrimental effect clinical outcomes in IVF/ICSI cycles. However, few studies explored whether slightly also same impact outcomes. Methods We retrospectively of GnRH-ant Propensity score matching used to confounding variables. The women were divided into two groups according level: Group 1: < 1.0 ng/ml; 2: ng/ml–1.5 ng/ml. Then compare pregnancy rate (CPR) between groups....
Platinum doublet chemotherapy is the standard of care in patients with non-small-cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutation who had disease progression after tyrosine kinase inhibitor (TKI). We aimed to assess immune checkpoint inhibitors efficacy EGFR-mutant advanced NSCLC.We retrospectively reviewed data sensitive NSCLC progressed EGFR-TKIs and received platinum plus immunotherapy between 2015 2021. Efficacy outcomes, including overall response...
Giant cell tumors (GCTs) mainly occur in metaphyses of long bones and are generally considered histologically benign; however, GCTs may be locally aggressive with a high rate local recurrence exhibit the potential for distant metastasis. Primary GCT clivus is extremely rare easily misdiagnosed and, thus, treatment remains controversial. The present report describes case 22‑year‑old male located skull base originating from clivus, involvement multiple cranial nerves, which was successfully...
Acute myeloid leukemia (AML) is the most common leukemia. It highly malignant, thus, patients with AML will relapse and die after traditional treatment. Stat3, a member of signal transducer activator transcription (Stat) family, involved in development progression many tumors. The purpose study was to investigate whether down-regulation Stat3 expression by RNA interference effective against human HL-60 cells. results indicated that constitutively expressed present cells, caused significant...
Maturation of tRNA depends on a single endonuclease, ribonuclease P (RNase P), to remove highly variable 5' leader sequences from precursor transcripts. Here, we use high-throughput enzymology report multiple-turnover and single-turnover kinetics for Escherichia coli RNase processing all possible sequences, including nucleotides contacting both the RNA protein subunits P. The results reveal that identity N(-2) N(-3) relative cleavage site at N(1) primarily control alternative substrate...
<h3>Background</h3> Low-pass genome sequencing (LP GS) is an alternative to chromosomal microarray analysis (CMA). However, validations of LP GS as a prenatal diagnostic test for amniotic fluid are rare. Moreover, depth in diagnosis has not been evaluated. <h3>Objective</h3> The performance was compared with CMA using 375 samples. Then, evaluated by downsampling. <h3>Results</h3> and had the same yield (8.3%, 31/375). showed all copy number variations (CNVs) detected six additional variant...
Abstract: The clinical activity and favorable toxicity profile of osimertinib has led it to be approved not only for advanced non-small cell lung cancer (NSCLC) patients with T790M-positive tumors when first, or second-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) treatment fails, but also untreated NSCLC EGFR sensitizing mutation, so how manage who get acquired resistance becoming an emerging challenge. This presentation would report a case patient 19DEL...