A5101996733- Neonatal Health and Biochemistry
- Antibiotic Resistance in Bacteria
- Genetics, Aging, and Longevity in Model Organisms
- CRISPR and Genetic Engineering
- Receptor Mechanisms and Signaling
- Adenosine and Purinergic Signaling
- Angiogenesis and VEGF in Cancer
- Cystic Fibrosis Research Advances
- Pneumonia and Respiratory Infections
- Heme Oxygenase-1 and Carbon Monoxide
- Methemoglobinemia and Tumor Lysis Syndrome
- Cancer Research and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Prion Diseases and Protein Misfolding
- Renin-Angiotensin System Studies
- RNA Research and Splicing
- Folate and B Vitamins Research
- Thyroid Cancer Diagnosis and Treatment
- Phenothiazines and Benzothiazines Synthesis and Activities
- Fungal and yeast genetics research
- Reproductive Biology and Fertility
- Cancer, Hypoxia, and Metabolism
- Neuropeptides and Animal Physiology
- Neonatal Respiratory Health Research
University of Pittsburgh
2014
Colorado College
2014
UPMC Hillman Cancer Center
2003
University of Illinois Urbana-Champaign
2002
Harvard University
2002
Cornell University
1988-1990
Temple University
1971-1976
St. Christopher's Hospital for Children
1971
The growth of transformed mouse fibroblasts (3T6 cells) in medium containing 5% fetal bovine serum was inhibited after treatment with concentrations greater than 50 microM ATP, ADP, or AMP. Adenosine, the common catabolite nucleotides, had no effect on cell at below 1 mM. However, following results indicate that toxicity and AMP is mediated by serum- cell-associated hydrolysis nucleotides to adenosine. 1) ADP AMP, but not were toxic 3T6 cells grown serum-free which phosphohydrolase activity...
The KH domain protein MEX-3 is central to the temporal and spatial control of PAL-1 expression in C. elegans early embryo. a Caudal-like homeodomain that required specify fate posterior blastomeres. While pal-1 mRNA present throughout oocyte embryo, expressed only blastomeres, starting at four-cell stage. To better understand how regulated temporally spatially, we have identified interacting proteins (MIPs) characterized detail two are for patterning expression. RNA interference MEX-6, CCCH...
Tumor progression largely depends on blood supply and neovessel formation, angiogenesis is emerging as a promising target for cancer therapy. Vascular endothelial growth factor (VEGF), major proangiogenic molecule, stimulates via promoting proliferation, survival migration. VEGF has been found to be up-regulated in various types of tumors associated with tumor poor prognosis. Inhibition or its signaling pathway shown suppress growth. In the present study, we tested antiangiogenic antitumor...
3'-O-(4-Benzoyl)benzoyl-ATP (BzATP), a photoaffinity analog of ATP, was used as ligand for P2Y purinoceptor (adenine nucleotide receptor) present in intact Swiss 3T3 and 3T6 cells A-431 epidermoid carcinoma cells. Photolysis serum-starved the presence 10-50 microM BzATP, followed by extensive washing to remove unincorporated induced release arachidonic acid. A trace (less than 0.01%) photoincorporated BzATP effective when 50 or ATP contained incubation medium during assay. Photoincorporated...