A5100782900- Adaptive Dynamic Programming Control
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Circular RNAs in diseases
- Lung Cancer Research Studies
- Optimism, Hope, and Well-being
- Lung Cancer Treatments and Mutations
- Reinforcement Learning in Robotics
- Mycobacterium research and diagnosis
- MicroRNA in disease regulation
- Esophageal Cancer Research and Treatment
- Trauma Management and Diagnosis
- Gastrointestinal disorders and treatments
- Pleural and Pulmonary Diseases
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Adaptive Control of Nonlinear Systems
- Eicosanoids and Hypertension Pharmacology
- Machine Learning and ELM
- Airway Management and Intubation Techniques
- Phagocytosis and Immune Regulation
- Respiratory Support and Mechanisms
- Viral Infections and Vectors
- Neural Networks and Applications
- Mathematical and Theoretical Epidemiology and Ecology Models
Guangdong Medical College
2016-2025
China Medical University
2008-2024
First Hospital of China Medical University
2008-2023
State Key Laboratory of Respiratory Disease
2019
National Clinical Research Center for Digestive Diseases
2019
Key Laboratory of Guangdong Province
2016
9005 Background: ADJUVANT-CTONG1104, a randomized phase 3 trial showed adjuvant gefitinib treatment significantly improved disease-free survival (DFS) vs standard doublet chemotherapy in patients (pts) with epidermal growth factor receptor ( EGFR) mutation-positive resected stage II-IIIA (N1-N2) non-small-cell lung cancer (NSCLC). 5-year rate of N1N2 were 38%-50% IASLC staging system. Here, we present the final overall (OS) results from study. Methods: From Sep 2011 to April 2014, 222...
N6-Methyladenosine (m6A), a prevalent and dynamically regulated chemical modification, has recently emerged as crucial post-transcriptional regulator of gene expression, affected diverse eukaryotic biological processes. However, the role m6A modification in aging research was still rarely reported. Herein, we uncovered that both level expression methyltransferase METTL3 were significantly elevated during process, observed physiological mouse model vivo, cellular senescence vitro....
The article investigates full information control problem for switched neural networks subject to fault and disturbance. First, the main objective is realizing interval stability zero tracking error under condition that neither of neuron states' vectors including plant reference models available. Second, desired controller networks' observer are designed ensure observer-based dynamic system mean-square exponentially stable with sufficient strict weight <inline-formula...
Abstract Background and Aim Esophageal carcinoma has been regarded as one of the top 10 common malignancies globally. squamous cell (ESCC) is an important subtype esophageal with approximately 20% survival rate. Long noncoding RNAs were documented to regulate occurrence or progression several tumors. However, neither biological role nor molecular mechanism LINC00467 explored. This research aimed investigating regulatory in ESCC. Methods In this study, a series experiments including reverse...
The abnormal expression and regulation of circular RNA (circRNA) is involved in the occurrence development a variety tumors. current study aimed to determine role circRNA_141539 esophageal squamous cell carcinoma (ESCC). CircRNA_141539 ESCC was detected via circRNA chip analysis verified reverse transcription-quantitative PCR. Associations between circRNA_141539, patient clinicopathological characteristics prognosis were also statistically analyzed. Additionally, effects on proliferation...
Oesophageal cancer is the eighth most common cause of worldwide. In 2009 in China, incidence and death rate oesophageal was 22.14 per 100 000 person-years 16.77 person-years, respectively, highest world. Minimally invasive oesophagectomy (MIO) introduced into clinical practice with aim reducing morbidity rate. The mechanisms MIO may lie minimising reaction to surgical injury inflammation. There are some randomised trials regarding minimally versus open oesophagectomy, 100-850 subjects...
Long noncoding RNAs (lncRNAs) have gained extensive attentions in recent years because of their potential importance a variety biological and pathological processes. In this study, we sought to explore the role lncRNAs cellular senescence. Here, report that lncRNA AK156230 was downregulated during replicative senescence mouse embryonic fibroblasts (MEFs), knockdown promotes robust phenotype, including increase numbers senescence-associated β-galactosidase-positive cells, decrease cell...
In this article, the optimal control strategy for organism is investigated by using adaptive dynamic programming (ADP) method under architecture of nonzero-sum games (NZSGs). First, a tumor model established to formulate interaction relationships among normal cells, endothelial and concentrations drugs. Then, ADP-based single-critic network proposed approximate coupled Hamilton–Jacobi equations (HJEs) medicine dosage regulation mechanism (MDRM). According game theory, MDRM-based can be...
We report a case of esophageal schwannoma in 62-year-old woman with 10-month history dysphagia and dyspnea. Chest computed tomography showed giant mediastinal mass maximum diameter 9 cm, extrinsically compressing the trachea esophagus. With large mucosal defect poor blood supply after removal tumor, we had to perform partial esophagectomy esophagogastrostomy right thorax (Ivor-Lewis procedure). Pathologic immunohistochemical examinations revealed benign schwannoma.
<title>Abstract</title> <bold>OBJECTIVE:</bold> The aim of this study was to develop a machine learning model that can predict spread through air space (STAS) lung adenocarcinoma preoperatively. STAS is associated with poor prognosis in invasive adenocarcinoma. Therefore non-invasive and accurate pre-surgical prediction patients essential for individualised patient management. <bold>METHODS：</bold>We included 138 who underwent lobectomy, collected their preoperative imaging data clinical...
Abstract Background: The epidermal growth factor receptor (EGFR) is one of the most commonly altered genes in non-small cell lung cancer(NSCLC). Of these, insertion mutation 20 exon (Ex20ins) EGFR occurs less frequently. In comparison with common mutations (19Del/L858R), NSCLC patients Ex20ins have a worse prognosis. Recently, FDA approved targeted oral therapeutic agent for EX20ins mutation, which has markedly improved their survival. Here we carry out complete analysis frequency and types...
A retrospective analysis was carried out in 36 patients with blunt diaphragmatic rupture during March 1991 and 2006. Twenty-two diagnoses were confirmed preoperatively, the rest 14were perioperatively. Three underwent surgical treatment after no response to conservative therapy. Thoracotomy performed 21 patients, laparotomy 9, thoracotomy plus 5 combined thoraco-laparotomy 1. Most may be caused by collision could lead thoracoabdominal injury. In spite of high mortality rate, condition is...