A5041998025- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Effects and risks of endocrine disrupting chemicals
- Uterine Myomas and Treatments
- Prenatal Substance Exposure Effects
- Cannabis and Cannabinoid Research
- Growth Hormone and Insulin-like Growth Factors
- Curcumin's Biomedical Applications
- Toxic Organic Pollutants Impact
- Kruppel-like factors research
- Spine and Intervertebral Disc Pathology
- Endometrial and Cervical Cancer Treatments
- Esophageal Cancer Research and Treatment
- Advanced battery technologies research
- Peroxisome Proliferator-Activated Receptors
- PI3K/AKT/mTOR signaling in cancer
- Neuroscience of respiration and sleep
- Supercapacitor Materials and Fabrication
- Therapeutic Uses of Natural Elements
- Genetic Syndromes and Imprinting
- Spinal Hematomas and Complications
- Case Reports on Hematomas
- Spinal Fractures and Fixation Techniques
- Bamboo properties and applications
- Urologic and reproductive health conditions
Washington State University
2021-2025
Hong Kong Polytechnic University
2024
Northeast Normal University
2023
Xi'an University of Architecture and Technology
2023
Third Hospital of Hebei Medical University
2020-2021
Hebei Medical University
2020-2021
Southern Illinois University School of Medicine
2017-2021
Nantong Tumor Hospital
2015-2021
Weatherford College
2020
Spinal Research
2020
Curcumin, an active ingredient from the rhizome of plant, Curcuma longa, has antioxidant, anti-inflammatory and anti-cancer activities. It recently been demonstrated that chemopreventive activities curcumin might be due to its ability inhibit cell growth induce apoptosis. In present study, we have investigated effects on apoptosis in human ovarian cancer line Ho-8910 by MTT assay, fluorescence microscopy, flow cytometry Western blotting. Our data revealed could significantly cells. A...
This study was performed to examine whether prenatal exposure bisphenol (BP) A analogues, BPE and BPS, negatively impacts male reproductive functions testis development using mice as a model. CD-1 were orally exposed control treatment (corn oil), BPA, BPE, BPS (0.5, 20, or 50 µg/kg/day) from gestational day 11 (the presence of vaginal plug = 1) birth. Although sperm counts significantly reduced by on postnatal (PND) 60, only remained low for motility. Exposure disrupted the progression germ...
Abstract This study was performed to examine the transgenerational effects of bisphenol (BP) A analogs, BPE, and BPS on male reproductive functions using mice as a model. CD-1 (F0) were orally exposed control treatment (corn oil), BPA, or (0.5 50 µg/kg/day) from gestational day 7 (the presence vaginal plug = 1) birth. Mice F1 F2 offspring used generate F3 males. Prenatal exposure decreased sperm counts and/or motility disrupted progression germ cell development morphometric analyses...
This study was performed to examine whether prenatal exposure bisphenol (BP) A analogues, BPE and BPS, negatively impacts female reproductive functions follicular development using mice as a model. CD-1 were orally exposed control treatment (corn oil), BPA, BPE, or BPS (0.5, 20, 50 µg/kg/day) from gestational day 11 (the presence of vaginal plug = 1) birth. Exposure accelerated the onset puberty exhibited abnormal estrous cyclicity, especially with lower doses. Females mating difficulties...
The aim of the present study was to clarify biomechanical properties oblique lumbar interbody fusion (OLIF) using different fixation methods in normal and osteoporosis spines.Normal intact finite element models L1 -S1 were established based on CT images a healthy male volunteer. Group A group B model. Each included four subgroups: (i) intact; (ii) stand-alone cage (Cage); (iii) with lateral plate two screws (LP); (iv) bilateral pedicle rods (BPSR). L3 -L4 level defined as surgical segment....
Endometriosis is an inflammatory disease associated with chronic pelvic pain (CPP). Growing evidence indicates that endometriotic lesions are not the sole source of pain. Instead, central nervous system (CNS) dysfunction created by prolonged peripheral and sensitization plays a role in developing endometriosis-associated CPP. This study investigated how CPP established using multiple lesion induction mouse model endometriosis, as repeated retrograde menstruation considered underlying...
The use of cannabis during pregnancy and nursing is a growing public health concern, the multigenerational impacts perinatal exposure remain largely unknown. To address this knowledge gap, we sought to examine long-term consequences on reproductive function how it might impact subsequent generations. Pregnant female mice were exposed control vehicle or extract [25, 100, 200 mg/ml Δ9-tetrahydrocannabinol (THC) in extract] from gestational day 1 postnatal 21 (twice/day), encompassing duration...
Abstract The use of cannabis during pregnancy and nursing is a growing public health concern, the multigenerational impacts perinatal exposure remain largely unknown. To address this knowledge gap, we sought to examine long-term consequences on reproductive function how it might impact subsequent generations. Pregnant female mice were exposed control vehicle or extract [25, 100, 200 mg/ml Δ9-tetrahydrocannabinol (THC) in extract] from gestational day 1 postnatal 21 (twice/day), encompassing...
This study was performed to examine the transgenerational effects of bisphenol (BP) A analogs, BPE, and BPS on female reproductive functions using mice as a model. CD-1 (F0) were orally exposed control treatment (corn oil), BPA, or (0.5 50 µg/kg/day) from gestational day 7 (the presence vaginal plug = 1) birth. Mice F1 F2 offspring used generate F3 females. Prenatal exposure accelerated onset puberty exhibited abnormal estrous cyclicity in females, those females mating difficulties starting...
Recent studies have demonstrated an essential role for insulin signaling in folliculogenesis as conditional ablation of Igf1r primary follicles elicits defective follicle-stimulating hormone responsiveness blocking development at the preantral stage. Thus potential action periovulatory window and corpus luteum is unknown. To examine this, we generated Insr,Igf1r, double receptor knockout mice driven by Pgr-Cre. These models escape follicle block response to superovulatory gonadotropins...
Abstract Insulin signaling is critical for the development of preovulatory follicles and progression through antral stage. Using a conditional knockout model that escapes this blockage, we recently described role insulin in granulosa cells during periovulatory window mice lacking Insr Igf1r driven by Pgr‐Cre . These were infertile, exhibiting defects ovulation, luteinization, steroidogenesis, early embryo development. Herein, demonstrate while these exhibit normal uterine receptivity, cell...
Immune dysfunction is one of the central components in development and progression endometriosis by establishing a chronic inflammatory environment. Western-style high-fat diets (HFD) have been linked to greater systemic inflammation cause metabolic diseases, are also considered an environmental risk factor for gynecologic diseases. Here, we aimed examine how HFD environment discern their contribution endometriotic-associated hyperalgesia. Our results showed that HFD-induced obesity enhanced...
Abstract Endometriosis is a common gynecological disease, which causes chronic pelvic pain and infertility in women of reproductive age. Due to limited efficacy current treatment options, critical need exists develop new effective treatments for endometriosis. Niclosamide an efficacious FDA-approved drug the helminthosis humans that has been used decades. We have reported niclosamide reduces growth progression endometriosis-like lesions via targeting STAT3 NFĸB signaling mouse model To...
Hydrogen peroxide (H(2)O(2)), a representative ROS, has been used to study the apoptosis of cancer cells oxidative stress. In this study, we exploited cellular and molecular mechanisms involved in H(2)O(2)-induced human gastric carcinoma MGC803 cells. Exposure H(2)O(2) might cause significant viability loss increase apoptotic rate. Treatment with 0.4 mmol/L up-regulated Bax but down-regulated Bcl-2 time-dependent manner, while Bcl-xL expression remained unchanged. Our results also showed...
Endometriosis causes severe chronic pelvic pain and infertility. We have recently reported that niclosamide treatment reduces growth progression of endometriosis-like lesions inflammatory signaling (NF|${\rm \small K}$|B STAT3) in a mouse model. In the present study, we examined further inhibitory mechanisms by which affects endometriotic using an epithelial cell line, 12Z, macrophages differentiated from monocytic THP-1 line. Niclosamide dose dependently reduced 12Z viability, STAT3...
Abstract Ovarian cancer (OvCa) remains the most common cause of death from gynecological malignancies. Genetically engineered mouse models have been used to study initiation, origin, progression, and/or mechanisms OvCa. Based on clinical features OvCa, we examined a quadruple combination pathway perturbations including PTEN, TRP53, RB1, CDH1. To characterize cancer-promoting events in ovarian surface epithelium (OSE), Amhr2cre/+ mice were ablate floxed alleles Pten, Trp53, and Cdh1, which...
Endometriosis is a chronic inflammatory disease that causes debilitating pelvic pain in women. Macrophages are considered to be key players promoting progression, as abundant macrophages present ectopic lesions and elevated the peritoneum. In study, we examined role of GATA6 + peritoneal on endometriosis-associated hyperalgesia using mice with specific myeloid deficiency GATA6. Lesion induction induced disappearance TIM4 hi MHCII lo residential influx increased Ly6C monocytes macrophages....
Studies in mammalian species showed that Krüppel-like factor 2 (KLF2) regulates adipogenesis. However, its role birds is unclear. The objective of the current study was to explore expression and function KLF2 chicken Results (Gallus gallus [gKLF2]) greatly expressed abdominal adipose tissue, transcripts fluctuated during tissue development. In addition, gKLF2 lean broilers were greater at 1 wk age but lower 3, 5, 8 than those fat (P < 0.05). more preadipocytes mature adipocytes 0.05), level...
Abstract Due to the vital roles of macrophages in pathogenesis endometriosis, targeting could be a promising therapeutic direction. Here, we investigated efficacy niclosamide for resolution perturbed microenvironment caused by dysregulated mouse model endometriosis. Single-cell transcriptomic analysis revealed heterogeneity including three intermediate subtypes with sharing characteristics traditional “small” or “large” peritoneal (SPMs and LPMs) cavity. Endometriosis-like lesions (ELL)...
Oesophageal cancer is the eighth most common cause of worldwide. In 2009 in China, incidence and death rate oesophageal was 22.14 per 100 000 person-years 16.77 person-years, respectively, highest world. Minimally invasive oesophagectomy (MIO) introduced into clinical practice with aim reducing morbidity rate. The mechanisms MIO may lie minimising reaction to surgical injury inflammation. There are some randomised trials regarding minimally versus open oesophagectomy, 100-850 subjects...
Previous microarray analyses revealed that LMO4 is expressed in 3T3‐L1 preadipocytes, however, its roles adipogenesis are unknown. In the present study, using RT‐PCR sequencing and quantitative real‐time RT‐PCR, we confirmed gene preadipocytes expression peaks at early stage of preadipocyte differentiation. Further showed knockdown decreased proliferation attenuated differentiation as evidenced by reduced lipid accumulation down‐regulation PPARγ expression. Collectively, our findings...