A5031453988- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Uterine Myomas and Treatments
- Effects and risks of endocrine disrupting chemicals
- Growth Hormone and Insulin-like Growth Factors
- Gestational Diabetes Research and Management
- Mesenchymal stem cell research
- Chemotherapy-related skin toxicity
- Toxic Organic Pollutants Impact
- Reproductive Biology and Fertility
- Multiple Myeloma Research and Treatments
- Fibroblast Growth Factor Research
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Cancer Treatment and Pharmacology
- Single-cell and spatial transcriptomics
- PI3K/AKT/mTOR signaling in cancer
- Prenatal Screening and Diagnostics
- Tissue Engineering and Regenerative Medicine
- Kruppel-like factors research
- Cancer Risks and Factors
- Ovarian function and disorders
- Ovarian cancer diagnosis and treatment
- Physical Activity and Health
Medical College of Wisconsin
2021-2025
Southern Illinois University School of Medicine
2018-2021
Abstract This study was performed to examine the transgenerational effects of bisphenol (BP) A analogs, BPE, and BPS on male reproductive functions using mice as a model. CD-1 (F0) were orally exposed control treatment (corn oil), BPA, or (0.5 50 µg/kg/day) from gestational day 7 (the presence vaginal plug = 1) birth. Mice F1 F2 offspring used generate F3 males. Prenatal exposure decreased sperm counts and/or motility disrupted progression germ cell development morphometric analyses...
This study was performed to examine whether prenatal exposure bisphenol (BP) A analogues, BPE and BPS, negatively impacts female reproductive functions follicular development using mice as a model. CD-1 were orally exposed control treatment (corn oil), BPA, BPE, or BPS (0.5, 20, 50 µg/kg/day) from gestational day 11 (the presence of vaginal plug = 1) birth. Exposure accelerated the onset puberty exhibited abnormal estrous cyclicity, especially with lower doses. Females mating difficulties...
This study was performed to examine the transgenerational effects of bisphenol (BP) A analogs, BPE, and BPS on female reproductive functions using mice as a model. CD-1 (F0) were orally exposed control treatment (corn oil), BPA, or (0.5 50 µg/kg/day) from gestational day 7 (the presence vaginal plug = 1) birth. Mice F1 F2 offspring used generate F3 females. Prenatal exposure accelerated onset puberty exhibited abnormal estrous cyclicity in females, those females mating difficulties starting...
Recent studies have demonstrated an essential role for insulin signaling in folliculogenesis as conditional ablation of Igf1r primary follicles elicits defective follicle-stimulating hormone responsiveness blocking development at the preantral stage. Thus potential action periovulatory window and corpus luteum is unknown. To examine this, we generated Insr,Igf1r, double receptor knockout mice driven by Pgr-Cre. These models escape follicle block response to superovulatory gonadotropins...
Abstract Insulin signaling is critical for the development of preovulatory follicles and progression through antral stage. Using a conditional knockout model that escapes this blockage, we recently described role insulin in granulosa cells during periovulatory window mice lacking Insr Igf1r driven by Pgr‐Cre . These were infertile, exhibiting defects ovulation, luteinization, steroidogenesis, early embryo development. Herein, demonstrate while these exhibit normal uterine receptivity, cell...
Abstract Endometriosis is a common gynecological disease, which causes chronic pelvic pain and infertility in women of reproductive age. Due to limited efficacy current treatment options, critical need exists develop new effective treatments for endometriosis. Niclosamide an efficacious FDA-approved drug the helminthosis humans that has been used decades. We have reported niclosamide reduces growth progression endometriosis-like lesions via targeting STAT3 NFĸB signaling mouse model To...
Endometriosis causes severe chronic pelvic pain and infertility. We have recently reported that niclosamide treatment reduces growth progression of endometriosis-like lesions inflammatory signaling (NF|${\rm \small K}$|B STAT3) in a mouse model. In the present study, we examined further inhibitory mechanisms by which affects endometriotic using an epithelial cell line, 12Z, macrophages differentiated from monocytic THP-1 line. Niclosamide dose dependently reduced 12Z viability, STAT3...
Abstract Ovarian cancer (OvCa) remains the most common cause of death from gynecological malignancies. Genetically engineered mouse models have been used to study initiation, origin, progression, and/or mechanisms OvCa. Based on clinical features OvCa, we examined a quadruple combination pathway perturbations including PTEN, TRP53, RB1, CDH1. To characterize cancer-promoting events in ovarian surface epithelium (OSE), Amhr2cre/+ mice were ablate floxed alleles Pten, Trp53, and Cdh1, which...
Endometriosis, a common gynecological disease, causes chronic pelvic pain and infertility in women of reproductive age. Due to the limited efficacy current therapies, critical need exists develop new treatments for endometriosis. Inflammatory dysfunction, instigated by abnormal macrophage (MΦ) function, contributes disease development progression. However, fundamental role heterogeneous population peritoneal MΦ their potential druggable functions is uncertain. Here we report that...
Palmar-plantar erythrodysesthesia, commonly known as hand-foot syndrome (HFS), is a side-effect of cancer chemotherapeutic agents such capecitabine. Patients with HFS oftentimes present palmoplantar numbness, tingling, burning pain, and/or hyperpigmentation; in advanced grades, blistering and ulceration may occur. In this article, we the case Black patient grade 1 post-capecitabine treatment for metastasized breast cancer. Prompt recognition atypical symptom presentation people color...
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Amniogenesis is triggered in a collection of pluripotent epiblast cells as the human embryo implants. To gain insights into critical but poorly understood transcriptional machinery governing amnion fate determination, we examined evolving transcriptome developing stem cell-derived model at single cell level. This analysis revealed several continuous amniotic progressing states with state-specific markers, which include previously unrecognized CLDN10+ progenitor state. Strikingly, found that...