A5100747283- Cancer Genomics and Diagnostics
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Computational Drug Discovery Methods
- Neuroinflammation and Neurodegeneration Mechanisms
- Plant-based Medicinal Research
- Viral Infections and Vectors
- Cancer Mechanisms and Therapy
- Extracellular vesicles in disease
- RNA modifications and cancer
- Bioinformatics and Genomic Networks
- Vitamin C and Antioxidants Research
- Neuroendocrine regulation and behavior
- Alcoholism and Thiamine Deficiency
- Kruppel-like factors research
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Cancer-related Molecular Pathways
- Thermal Regulation in Medicine
- Immune Response and Inflammation
- Gene Regulatory Network Analysis
- Colorectal Cancer Treatments and Studies
- Epigenetics and DNA Methylation
- Pharmacological Receptor Mechanisms and Effects
Lanzhou University
2019-2025
Lanzhou University Second Hospital
2019-2025
Stanford Medicine
2023
Stanford University
2015-2020
University of Helsinki
2014-2017
5-Hydroxymethylcytosine (5hmC) is an important mammalian DNA epigenetic modification that has been linked to gene regulation and cancer pathogenesis. Here we explored the diagnostic potential of 5hmC in circulating cell-free (cfDNA) using a sensitive chemical labeling-based low-input shotgun sequencing approach. We sequenced from 49 patients seven different types found distinct features could be used predict stages with high accuracy. Specifically, discovered lung leads progressive global...
Abstract The decreasing cost of genomic technologies has enabled the molecular characterization large-scale clinical disease samples and changes upon drug treatment in various models. Exploring methods to relate diseases potentially efficacious drugs through features is critically important discovery new therapeutics. Here we show that potency a reverse cancer-associated gene expression positively correlates with drug’s efficacy preclinical models breast, liver colon cancers. Using...
// Li Ma 1 , Xiaolin Wang 1, 3 Tao Jia 2 Wei Mei-Sze Chua Samuel So Asian Liver Center and Department of Surgery, Stanford University School Medicine, University, Stanford, CA 94305, USA Pharmaceutical Sciences, Wuhan Wuhan, Hubei, 430072, China Guangdong Institute Gastroenterology, Provincial Key Laboratory Colorectal Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen Guangzhou, Guangdong, 510655, Correspondence to: Chua, e-mail: mchua@stanford.edu Keywords: WNT/β-catenin...
Sepsis is a potentially fatal condition characterized by organ failure resulting from an abnormal host response to infection, often leading liver and kidney damage. Timely recognition intervention of these dysfunctions have the potential significantly reduce sepsis mortality rates. Recent studies emphasized critical role serum exosomes their miRNA content in mediating sepsis-induced dysfunction. The objective this study elucidate mechanism underlying impact miR-122-5p on sepsis-associated...
Several behavioral interventions, based on social enrichment and observational learning are applied in treatment of neuropsychiatric disorders. However, the mechanism such modulatory effect safety methods individuals involved support need further investigation. We took advantage known differences between inbred mouse strains to reveal behavior neurobiology animals with different phenotypes. C57BL/6 DBA/2 female mice displaying multiple cognitive, social, emotional were group-housed either...
Accumulating evidence reveals esmolol could protect the gut mucosa through regulation of immune response and inflammation in patients with sepsis. However, its underlying mechanism is not fully understood.Diamine oxidase (DAO), intestinal fatty acid-binding protein (I-FABP), interleukin (IL)-6, IL-10 plasma rats were detected by ELISA assay. Western blotting was utilized to measure expression levels NF-kappa B-p65, Bcl-2, cleaved caspase-3 tissues. The survival analysis performed each...
Hepatocellular carcinoma (HCC) is a typically fatal malignancy with limited treatment options and poor survival rates, despite recent FDA approvals of newer options. We aim to address this unmet need by using proprietary computational drug discovery platform that identifies candidates the potential advance rapidly successfully through preclinical studies.
Abstract Hepatocellular carcinoma (HCC) and pancreatic ductal adenocarcinoma (PDAC) have among the lowest 5-year survival rates of all cancer types at 18% 9%, respectively. Treatment options for patients with liver or are relatively unchanged over past 10 years. HCC has seen recent FDA-approval multi-kinase inhibitor therapies similar mechanisms action, including cabozantinib, regorafenib, lenvatinib, immune checkpoint nivolumab (conditionally). Despite these advances, rate median time...