Owing to the inherent instability caused by low Cu(I)/Cu(0) half-cell reduction potential, Cu(0)-containing copper nanoclusters are quite uncommon in comparison their Ag and Au congeners. Here, a novel eight-electron superatomic nanocluster [Cu31(4-MeO-PhC≡C)21(dppe)3](ClO4)2 (Cu31, dppe = 1,2-bis(diphenylphosphino)ethane) is presented with total structural characterization. The determination reveals that Cu31 features an chiral metal core arising from helical arrangement of two sets three...

// Li Ma 1 , Xiaolin Wang 1, 3 Tao Jia 2 Wei Mei-Sze Chua Samuel So Asian Liver Center and Department of Surgery, Stanford University School Medicine, University, Stanford, CA 94305, USA Pharmaceutical Sciences, Wuhan Wuhan, Hubei, 430072, China Guangdong Institute Gastroenterology, Provincial Key Laboratory Colorectal Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen Guangzhou, Guangdong, 510655, Correspondence to: Chua, e-mail: mchua@stanford.edu Keywords: WNT/β-catenin...

Ln3+‐induced ligand up‐conversion luminescence (UCL) in coordination polymers (CPs) effectively overcomes the inherent limitations of conventional organic UCL mechanisms. However, current research on Ln‐CPs has predominantly focused Ln³⁺ ions themselves, while investigations into Ln³⁺‐induced have been overlooked Ln‐CPs. Herein, by doping Yb³⁺ [Y2(FCA)6]n (1) (FCA = 9‐fluorenone‐2‐carboxylic acid), we prepared Yb3+‐doped 1D chain [Y2‐2xYb2x(FCA)6]n ( x 0.2, 2; 0.5, 3; 0.7, 4; 0.9, 5; 1, 6)....

Ln3+‐induced ligand up‐conversion luminescence (UCL) in coordination polymers (CPs) effectively overcomes the inherent limitations of conventional organic UCL mechanisms. However, current research on Ln‐CPs has predominantly focused Ln³⁺ ions themselves, while investigations into Ln³⁺‐induced have been overlooked Ln‐CPs. Herein, by doping Yb³⁺ [Y2(FCA)6]n (1) (FCA = 9‐fluorenone‐2‐carboxylic acid), we prepared Yb3+‐doped 1D chain [Y2‐2xYb2x(FCA)6]n ( x 0.2, 2; 0.5, 3; 0.7, 4; 0.9, 5; 1, 6)....

Induction of multidrug resistance by doxorubicin (DOX), together with non-specific toxicities, has restricted DOX-based chemotherapy. Recently, we demonstrated that DOX conjugated an EGF receptor-binding peptide (DOX-EBP) had enhanced anticancer efficacy and reduced systemic toxicity when targeting receptor-overexpressing tumours. Here investigated whether DOX-EBP is able to overcome drug the underlying molecular mechanisms.DOX-resistant SW480/DOX cells were derived from non-resistant SW480...

The design of small molecular ligands able to bind with DNA is pivotal for the development diagnostic agents and therapeutic drugs targeting DNA. Carbazole-derivatives are potential against tumors opportunistic infections AIDS. Here, two carbazole-derived dicationic compounds, DPDI DPPDI, were designed, synthesized characterized using NMR, IR MS. binding properties DPPDI sensitive ionic strength. At low strength, planar aromatic had a strongly intercalative interaction DNA, which was...

With the application of big data in Earth observation, satellite imagery are gradually becoming important means observation for monitoring changes vegetation, water bodies, and urbanization. Therefore, new organization management paradigms urgently needed to fully mine useful information from these provide ways better quantify serve sustainable development resources environment. In this paper, a framework processing analyzing Chinese GF-1 was developed using latest technologies such as Open...

Coinage-metal clusters with excellent luminescence properties have attracted considerable interest due to their intriguing structures and potential applications. However, achieving strong near-infrared (NIR) in these is highly challenging. Here, we successfully synthesized the first Ln

The comprehensive quality evaluation of the lakefront landscape relies on a combination subjective and objective methods. This study aims to evaluate coupling coordination between spatial public sentiment in Wuhan’s area, explore distribution various types through machine learning street view images analysis microblog texts. Results show that: (1) hot cold spots are distributed contiguous pattern, whereas sentiments multiple clusters. (2) A strong correlation exists sentiment. High green...

Two cationic γ-carbolines, 2-methyl-5H-pyrido[4,3-b]indolium iodide (MPII) and 2,5-dimethyl-5H-pyrido[4,3-b]indolium (DPII), were synthesized, the DNA-binding properties of γ-carbolines elucidated. Through a series experiments, we proved that two could strongly interact with DNA by intercalative binding. However, DPII, methyl group substituting H atom 5-NH, has shown stronger interaction compared to MPII. The dissociation from 5-NH MPII resulted in better water solubility less binding...

A novel porphyrin-dextran coated Fe 3 O 4 nanoparticle (5) was designed and synthesized. The structure of 5 confirmed by IR, UV-vis inductively coupled plasma atomic emission spectrometry, dynamic laser scattering (DLS); magnetic property measured a vibrating sample magnetometer (VSM). interaction between compound human serum albumin (HSA) investigated through absorbance spectra fluorospectrophotometer, compared with the 5-(4-aminophenyl)-10,15,20-tris-(4-sulfonatophenyl)porphyrin, trisodium...

A convenient route for the synthesis of (S)-1-amino-2-(1-methoxy-1-methylethyl)pyrrolidine (SADP) was established. The involved three key steps viz. Grignard addition to N-Boc-proline ester (1), nitrosation aminoalcohol hydrochloride (3) and O-methylation alcohol group N-nitrosopyrrolidine (4). (S)-1,1-dimethyl– tetrahydropyrrolo[1,2-c]oxazol-3-one (6) also obtained via reaction (S)-1-Boc-2-(1-hydroxy-1- methylethyl)pyrrolidine (2) with sodium hydride. Keywords: Chiral hydrazine, addition,...

Background. Polyfluoroalkyl chemical (PFC) surfactants can cross the placenta. However, data on maternal PFCs concentrations during gestation and transfer of to fetus are limited. Aims. To correlate in paired maternal–cord sera determine potential changes gestation. Methods. In a multiethnic cohort pregnant women recruited 2003-2006 from Cincinnati, Ohio, USA, we measured four serum at approximately 16 weeks gestation, umbilical cord serum, collected delivery by on-line solid phase...